Tumor Lysis Syndrome in the 21st Century: To Recreate Risk Factors and Prognosis?

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“…We greatly appreciate the comments by Vincent et al [1] in reference to our recent article, "In-Hospital Outcomes of Tumor Lysis Syndrome: A Population-Based Study Using the National Inpatient Sample" [2], regarding both the surprisingly high rate of solid tumors associated with tumor lysis syndrome (TLS) as well as the inherent issues of a large database, namely the National Inpatient Sample (NIS). To address some of the potential potholes associated with a database based on discharge diagnoses, we did not include any patients with multiple or no coded malignancies.…”