Tumor Markers and Lung Cancer: Correlation between Serum and Bronchial Secretion Levels of Cea, Tpa, Canag Ca-50, Nse and Ferritin

Macchia, Vincenzo; Mariano, Angela; Cavalcanti, M. R.; Coppa, Anna; Cecere, C; Fraioli, G.; Elia, Stefano; Ferrante, G

doi:10.1177/172460088700200303

Cited by 19 publications

(12 citation statements)

References 3 publications

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“…A wide variability was found in both BALF and serum ferritin measurements, in agreement with literature data [11, 18]. This may be due to several causes, namely: (a) biological differences related to both variety in tumor histology, grading and staging, and individual host response to the disease; (b) methodological difficulties encountered with a visual-manual tool like bronchoscopy in identification of the target (in the bronchial part of the tumor, often located at the extreme periphery), and (c) technical adequacy of the operator(s), when minimal differences in gross procedures (i.e.…”

Section: Discussionsupporting

confidence: 80%

“…Unlike the serum concentration, ferritin in tumoral tissue and bronchoalveolar lavage fluid (BALF) has not been explored in the literature, particularly its biological role and possible diagnostic value as a tumor marker [10, 11, 12, 13]. Macchia et al [11]showed increased BALF ferritin values in patients with peripheral lung cancer compared to healthy controls, without any demonstration of significant sensitivity or specificity.…”

Section: Introductionmentioning

confidence: 99%

“…Macchia et al [11]showed increased BALF ferritin values in patients with peripheral lung cancer compared to healthy controls, without any demonstration of significant sensitivity or specificity. Maxim et al [14], using antisera against ferritin and lactoferrin, observed 80% positive results in lung tumor extracts versus 10% of other tumors, demonstrating an evident organ specificity of tumor-associated ferritin in lung cancer, as opposed to serum ferritin.…”

Section: Introductionmentioning

confidence: 99%

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A Comparative Study on Ferritin Concentration in Serum and Bilateral Bronchoalveolar Lavage Fluid of Patients with Peripheral Lung Cancer versus Control Subjects

Fracchia¹,

Ubbiali²,

ElBitar³

et al. 1999

Oncology

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Objectives: To assess the diagnostic value of bronchoalveolar lavage fluid (BALF) ferritin as a lung tumor marker by comparing serum and BALF ferritin concentrations in patients with peripheral lung cancer versus control subjects with benign lung disease, and to examine the theory of ferritin compartmentalization around the tumor area by comparing ferritin concentrations in serum and bilateral (affected and unaffected side) BALF in cancer patients. Methods: Four groups of patients were investigated: 10 control nonsmokers, 10 control smokers, 10 smokers with chronic obstructive pulmonary disease (COPD), and 22 patients with primary bronchogenic carcinoma. A bronchoalveolar lavage (BAL) was performed in all subjects (both sides in 13 oncological patients, one side in the others) and samples of BALF and blood were submitted to biochemical analysis. Results: As a lung tumor marker, BALF ferritin showed 54% sensitivity and 93% specificity and serum ferritin 22% sensitivity and 93% specificity. A significant difference was observed between the two sides in the cancer patients (p = 0.033), and between BALF ferritin from the affected side and COPD patients (p = 0.025). Greater differences were obtained when BALF ferritin in the affected side of cancer patients was compared with values in both control nonsmokers (p < 0.0001) and control smokers (p < 0.001). Conclusions: These findings seem to confirm the relative diagnostic value of BALF ferritin as a lung tumor marker and the theory of ferritin compartmentalization. However, further studies are required to clarify the relations between iron and ferritin on the one hand and inflammation, tumorigenesis and host response on the other.

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Comparative Study on Ferritin Concentration in Serum and Bilateral Bronchoalveolar Lavage Fluid of Patients with Peripheral Lung Cancer versus Control Subjects

Fracchia¹,

Ubbiali²,

ElBitar³

et al. 1999

Oncology

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“…10-Generally, CEA and Fuc-GMl expression was complementary (7 cases), i.e., the tumors contained areas expressing either of these antigens. 312 Brezicka [14,27,28]. In the present work, how ever, we report for the first time on the immunohistological expression of CA 50 in LC tis sue.…”

Section: Cellular Coexpression Oftaags In Sclcmentioning

confidence: 67%

Coexpression of Ganglioside Antigen Fuc-GM1, Neural-Cell Adhesion Molecule, Carcinoembryonic Antigen, and Carbohydrate Tumor-Associated Antigen CA 50 in Lung Cancer

Brezicka

Olling²,

Bergman³

et al. 1992

Tumor Biol

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With the aid of specific monoclonal antibodies, tumor tissues from 68 patients with lung cancer were examined for their expression of two small cell lung carcinoma (SCLC) antigens, Fuc-GMl (fucosyl GM1; IV²FucII³NeuAc GgOse₄) and neural-cell adhesion molecule (NCAM), and two broader tumor antigens, carcinoembryonic antigen (CEA) and carbohydrate cancer-associated antigen CA 50. Expression of Fuc-GMl was seen in 75% and NCAM in 78% of the SCLC specimens, but also in 12 and 20% of non-SCLC. Either or both of these antigens were expressed in more than 90% of SCLC and in 25% of non-SCLC. CEA was found in more than 80% of SCLC and non-SCLC. Expression of CA 50 was seen in 65–68% of non-SCLC and SCLC, showing preference for SCLC and lung adenocarcinoma. In SCLC, cellular expression of Fuc-GM1 was generally seen together with NCAM and CA 50, but rarely with CEA. There was considerable inter- and intratumor heterogeneity in the expression of all four antigens. The results suggest that CEA is the antigen of choice for the detection of lung cancer regardless of histotype. In combined analysis of CEA, CA 50, Fuc-GM1 and NCAM, two patterns of antigen expression were recognized that appear to discriminate between SCLC and non-SCLC tumors, respectively. A considerable fraction of SCLC and non-SCLC tumors, however, exhibited similar patterns of antigen expression. The biological and clinical significance of these observations remains to be investigated.

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“…Generally, serum levels of CEA were higher in lung cancer than those of benign pulmonary diseases, including COPD [11][12][13] . However, Sanguinetti et al [10] have shown that the mean serum CEA value in peripheral lung cancer patients did not differ from that in nonneoplastic and healthy subjects.…”

mentioning

confidence: 99%

Comparison of Serum CA 19.9, CA 125 and CEA Levels with Severity of Chronic Obstructive Pulmonary Disease

et al. 2009

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Objective: To investigate serum levels of CA 19.9, CA 125 and carcinoembryonic antigen (CEA) in patients with different stages of chronic obstructive pulmonary disease (COPD). Patients and Methods: Fifty-three consecutive patients (50 males, 3 females, mean age 67.6 ± 10.1 years) with COPD were included in this study. Serum levels of CA 19.9, CA 25 and CEA were determined by the chemiluminescent immunometric method. Based on values obtained from pulmonary function tests, the patients were divided into 3 groups: moderate (21), severe (18) and very severe (14). Data were analyzed with a Kruskal-Wallis one-way analysis of variance test and Mann-Whitney U test. Results: The mean serum levels of CA 125 and CA 19.9 were significantly higher in patients with very severe COPD (p = 0.013 and p = 0.017, respectively) than in patients with severe and moderate COPD (p < 0.05). Patients with cor pulmonale had significantly high mean serum levels of CEA, CA 19.9 and CA 125 (p < 0.05). Patients using a long-acting β-agonist and theophylline showed significantly higher mean serum levels of CA 125 than patients who were not (p < 0.05). Conclusion: Data showed that the increased serum tumor markers in patients with COPD might be due to the severity of COPD, medication and cor pulmonale.

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Tumor Markers and Lung Cancer: Correlation between Serum and Bronchial Secretion Levels of Cea, Tpa, Canag Ca-50, Nse and Ferritin

Cited by 19 publications

References 3 publications

A Comparative Study on Ferritin Concentration in Serum and Bilateral Bronchoalveolar Lavage Fluid of Patients with Peripheral Lung Cancer versus Control Subjects

A Comparative Study on Ferritin Concentration in Serum and Bilateral Bronchoalveolar Lavage Fluid of Patients with Peripheral Lung Cancer versus Control Subjects

Coexpression of Ganglioside Antigen Fuc-GM1, Neural-Cell Adhesion Molecule, Carcinoembryonic Antigen, and Carbohydrate Tumor-Associated Antigen CA 50 in Lung Cancer

Comparison of Serum CA 19.9, CA 125 and CEA Levels with Severity of Chronic Obstructive Pulmonary Disease

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