Tumor-mesoporous silica nanoparticle interactions following intraperitoneal delivery for targeting peritoneal metastasis

Hargrove, Derek; Liang, Brian; Kashfi‐Sadabad, Raana; Joshi, Gayatri; Gonzalez-Fajardo, Laura; Glass, Sterling; Jay, Michael; Salner, Andrew L.; Lü, Xiuling

doi:10.1016/j.jconrel.2020.11.003

Cited by 21 publications

(7 citation statements)

References 49 publications

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“…To further increase the penetration of cNPs in the stroma, some authors chose to thermally denature collagen. Interestingly, Hargrove et al [23] showed a lower concentration of mesoporous silica NPs in the disrupted collagen. This contradicts the results of Raeesi et al [29].…”

Section: Nanoparticles: Types and Synthesis Protocolsmentioning

confidence: 99%

“…Fourteen studies were selected based on the inclusion criteria [17][18][19][20][21][22][23][24][25][26][27][28][29][30] (Figure 1). The initial search found 603 manuscripts, out of which 108 were duplicates and were removed.…”

Section: Literature Review and Design Of Eligible Studiesmentioning

confidence: 99%

“…The coupling of CBPs to NPs is the key to actively targeting collagen in the tissues where it is overexposed or overexpressed. Two studies did not use CBPs to increase NPs collagentargeting sensitivity [23,29], instead the targeting was passive and based on the affinity of the cNPs. Instead of using CBPs, some authors analyzed the intrinsic ability of NPs to accumulate in the extracellular matrix.…”

Section: Nanoparticles: Types and Synthesis Protocolsmentioning

confidence: 99%

“…However, the chosen models vary; most researchers used well-plates, in which type IV collagen was cultivated, while others used specific cell lines (e.g., hepatic cell lines, smooth muscle). One study used a spheroid cell culture of an ovarian adenocarcinoma line [23] and one used a tissue sample of a mouse cornea [30], which is highly rich in collagen. In all experiments, CBNPs and cNPs were directly incubated with the experimental cell line and collagen-binding was quantified by using fluorescent imaging.…”

Section: In Vitro Studiesmentioning

confidence: 99%

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Collagen-Binding Nanoparticles: A Scoping Review of Methods and Outcomes

et al. 2021

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(1) Background: Collagen is the main component of the connective tissue, playing an important role in the histological architecture and function of living organisms. Targeted therapy and improved imaging diagnosis can be obtained through collagen-binding nanoparticles that concentrate in the extracellular matrix. (2) Methods: We performed a scoping review of studies that analyzed the binding capacity of collagen-targeting nanoparticles. The search algorithm and inclusion criteria were based on PRISMA and ARRIVE guidelines. (3) Results: Fourteen studies matched all the inclusion criteria. All studies analyzed the distribution of nanoparticles in the collagen matrix, either by using collagen-targeting nanoparticles or by using unmodified ones. Most studies used collagen-binding nanoparticles for vascular research to target sites of endothelial injury, atherosclerotic plaques, or myocardial infarction. Two studies targeted the exposed collagen in models of liver fibrosis. (4) Conclusions: Our review summarizes the current literature on the methods and outcomes of using nanoparticles to target collagen. The studies reveal that there is high applicability for collagen-binding nanoparticles in cardiac or hepatic pathology and they could prove useful for targeted therapy of neoplastic lesions, which show an abundance of stromal collagen.

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Section: Nanoparticles: Types and Synthesis Protocolsmentioning

confidence: 99%

Section: Literature Review and Design Of Eligible Studiesmentioning

confidence: 99%

Section: Nanoparticles: Types and Synthesis Protocolsmentioning

confidence: 99%

Section: In Vitro Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Collagen-Binding Nanoparticles: A Scoping Review of Methods and Outcomes

et al. 2021

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“…Mesoporous silica nanoparticles (MSNs) provide many advantages, including a simple process for synthesis, easy surface modification, and good biocompatibility. MSNs have become an inorganic carrier material that has been widely studied in the field of drug carriers during recent years ( Hargrove et al, 2020 ; Taweekarn et al, 2020 ; Wu et al, 2020 ). Gold nanorods (GNRs) are photothermal materials that can generate heat after near-infrared laser response.…”

Section: Introductionmentioning

confidence: 99%

MiR-197 Inhibitor Loaded AbCD133@MSNs@GNR Affects the Development of Prostate Cancer Through Targeting ITGAV

Zhu

et al. 2021

Front. Cell Dev. Biol.

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Prostate cancer is one of the most severe male malignant tumors, which ranks second in mortality rate among all tumors. Traditional methods of treatment for prostate cancer produce obvious side effects and a high recurrence rate. Cancer stem cells are considered to be a group of cells that determine the proliferation, metastasis, and drug resistance of tumor. Prostate cancer therapy based on microRNAs and prostate cancer stem cells (PCSCs) has been a research hot spot in this field. Previous studies have reported that miR-197 plays an important role in the occurrence and development of prostate cancer, but the molecular mechanism of miR-197 on the development of prostate cancer has not been reported yet. In this study, we verified that miR-197 is significantly overexpressed in prostate cancer tissues and prostate cancer cells. Then, we verified that miR-197 expression affects the proliferation, invasion, and metastasis of prostate cancer cells by regulating integrin subunit alpha V (ITGAV) expression through STAT5 pathway, and the results indicated that the miR-197 inhibitor can be a prostate cancer suppressor. Then we synthesized the AbCD133@GNR@MSNs@miR-197 inhibitor drug carrier, in which 35.42 μg of the miR-197 inhibitor could be loaded in 1 mg of AbCD133@GNR@MSNs. The AbCD133@GNR@MSNs@miR-197 inhibitor demonstrated good photothermal properties and photothermal controlled-release properties. The modified CD133 antibodies on the surface of the nano drug carrier helped more drug carriers to enter the PCSCs. The pharmacodynamic effects of the AbCD133@GNR@MSNs@miR-197 inhibitor on PCSCs in vivo and in vitro were studied under near-infrared radiation. The results showed that the AbCD133@GNR@MSNs@miR-197 inhibitor prepared in this study could not only significantly suppress the development of PCSCs through ITGAV/STAT5 pathway but also significantly suppress the growth of PCSC solid tumors. In short, our study verified that miR-197 regulates the development of PCSCs through STAT5 pathway by targeting ITGAV, and the AbCD133@MSNs@GNR@miR-197 inhibitor could be a potential suppressor used in prostate cancer treatment. In short, our study found that miR-197 affected the development of prostate cancer by regulating ITGAV. The AbCD133@GNR@MSNs@miR-197 inhibitor prepared in this study could suppress the development and growth of PCSCs in vitro and in solid tumors not only by targeting the ITGAV but also through photothermal therapy. Our study not only provides a theoretical basis for the clinical treatment of prostate cancer but also provides a research scheme of drug loading and microRNA-based photothermal controlled therapy for prostate cancer.

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