Tumor Microenvironment-Adaptive Nanoplatform Synergistically Enhances Cascaded Chemodynamic Therapy

Wang, Yuemin; Zhang, Yuyue; Xu, Hong; Shen, Luxuan; Cheng, Jing; Xu, Xinyuan; Tan, Hong; Chen, Xingyu; Li, Jianshu

doi:10.1016/j.bioactmat.2022.09.025

Cited by 39 publications

(38 citation statements)

References 64 publications

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“…The intracellular Fenton catalysis is carried out to convert endogenous H 2 O 2 into • OH to realize chemodynamic therapy (CDT), and the catalyst can also be defined as mimic peroxidase (POD). In fact, the H 2 O 2 level is limited (50–100 μM) in the tumor microenvironment (TME), and additional H 2 O 2 supplementation is desired to further promote CDT. − It is known that glucose oxidase (Gox) could catalyze glucose oxidation to provide H 2 O 2 . Glucose is present extensively in all organisms because its metabolism would supply energy for living cells.…”

Section: Introductionmentioning

confidence: 99%

Defect-Rich Ni–CoO@PEG Porous Hexagonal Nanosheets: Multi-enzyme and Ultrasound Catalysis for Synergistic Anticancer Treatment

Wang

Jia

et al. 2023

ACS Appl. Mater. Interfaces

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Given the similarity with photocatalysis, sonodynamic therapy (SDT) can be defined as ultrasonic (US) catalysis. Encouraged by the principles of photocatalysis and defect chemistry, defect-rich nickel (Ni)doped cobaltous oxide (Ni−CoO@PEG) porous hexagonal nanosheets have been synthesized as a sonosensitizer. The doping of Ni decreases the band gap that is testified by density functional theory to increase the US-generated charges. Under US irradiation, Ni−CoO@PEG nanosheets produce 1 O 2 as an active species that is determined by dissolved O 2 and electrons. Moreover, the doping also brings abundant oxygen vacancies (O V ) that not only are in favor of efficient separation of electron−hole but also enhance the interaction toward O 2 , boosting 1 O 2 generation. In addition, Ni−CoO@PEG shows robust mimic catalase (CAT) and peroxidase characterization to effectively improve the intratumor O 2 content and oxidation stress. What is more, the nanosheets also possess glucose oxidase activity that can consume glucose to elevate the H 2 O 2 /acid level and to block the intracellular energy supply. The tandem nanozyme behaviors would further regulate the tumor microenvironment for assisting anticancer treatment. It is noted that Ni−CoO@PEG reveals a novel half-metallic feature endowing great magnetism and magnetic resonance imaging capacity. The above synergistic treatments exhibit outstanding anticancer performance that also evokes antitumor immunity to suppress metastasis and recurrence, efficiently.

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Section: Introductionmentioning

confidence: 99%

Defect-Rich Ni–CoO@PEG Porous Hexagonal Nanosheets: Multi-enzyme and Ultrasound Catalysis for Synergistic Anticancer Treatment

Wang

Jia

et al. 2023

ACS Appl. Mater. Interfaces

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“…Cell membrane-modified nanocomposites (CMNCs) can precisely inherit the surface characteristics and membrane-related signalling pathways of the source cells, which are developed for drug delivery and cancer therapy. [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] The erythrocyte membrane, namely the red blood cell (RBC) membrane, is the first and the most commonly used one for the establishment of CMNCs. Owing to the highly flexible structure of RBCs and the proteins residing on the membrane which mediate the self-recognition of homologous RBCs, it exhibits excellent long circulation and immune escape abilities in vivo, which are favourable for enhancing the accumulation of therapeutic agents in the tumor.…”

Section: Introductionmentioning

confidence: 99%

An erythrocyte membrane-modified biomimetic synergistic nanosystem for cancer anti-vascular therapy and initial efficacy monitoring

Zhang

Song

et al. 2023

J. Mater. Chem. B

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“…Glucose oxidase (GOx), a widely used enzyme in the food industry, has attracted great attention in starvation therapy due to its property of catalyzing glucose into gluconic acid and hydrogen peroxide (H 2 O 2 ) . In addition to the glucose scavenging, the resultant H 2 O 2 can be further converted into hydroxyl radicals (•OH) and remarkably increase the oxidative stress of tumor cells, leading to severe cell apoptosis. , Furthermore, these ROS could reprogram tumor-associated macrophages (TAMs) from the inhibited state (M2 phenotype) to the antitumor M1 phenotype, thus activating residential immunity to promote antitumor efficiency. , …”

mentioning

confidence: 99%

“…8 In addition to the glucose scavenging, the resultant H 2 O 2 can be further converted into hydroxyl radicals (•OH) and remarkably increase the oxidative stress of tumor cells, leading to severe cell apoptosis. 9,10 Furthermore, these ROS could reprogram tumor-associated macrophages (TAMs) from the inhibited state (M2 phenotype) to the antitumor M1 phenotype, thus activating residential immunity to promote antitumor efficiency. 11,12 However, despite its multiple antitumor effects, the monotherapeutic efficiency of GOx is limited because of the abundant vessel networks around the tumor site for constant nutrition supply.…”

mentioning

confidence: 99%

Engineered Enzyme-Loaded Erythrocyte Vesicles Precisely Deprive Tumoral Nutrients to Induce Synergistic Near-Infrared-II Photothermal Therapy and Immune Activation

Nie

Pan

et al. 2023

ACS Nano

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Starvation therapy has been considered a promising strategy in cancer treatment for altering the tumor microenvironment (TME) and causing a cascade of therapeutic effects. However, it is still highly challenging to establish a therapeutic strategy for precisely and potently depriving tumoral nutrition. In this study, a glucose oxidase (GOx) and thrombin-incorporated erythrocyte vesicle (EV) with cyclic (Arg-Gly-Asp) (cRGD) peptide modification, denoted as EV@RGT, were synthesized for precisely depriving tumoral nutrition and sequentially inducing second near-infrared region (NIR-II) photothermal therapy (PTT) and immune activation. The EV@RGT could specifically accumulate at the tumor site and release the enzymes at the acidic TME. The combination of GOx and thrombin exhausts tumoral glucose and blocks the nutrition supply at the same time, resulting in severe energy deficiency and reactive oxygen species (ROS) enrichment within tumor cells. Subsequently, the abundant clotted erythrocytes in tumor vessels present outstanding localized NIR-II PTT for cancer eradication owing to the hemoglobin. Furthermore, the abundant ROS generated by enhanced starvation therapy repolarizes resident macrophages into the antitumor M1 phenotype via a DNA damage-induced STING/NF-κB pathway, ultimately contributing to tumor elimination. Consequently, the engineered EV@RGT demonstrates powerful antitumor efficiency based on precise nutrition deprivation, sequential NIR-II PTT, and immune activation effect. This work provides an effective strategy for the antitumor application of enzyme-based reinforced starvation therapy.

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Tumor Microenvironment-Adaptive Nanoplatform Synergistically Enhances Cascaded Chemodynamic Therapy

Cited by 39 publications

References 64 publications

Defect-Rich Ni–CoO@PEG Porous Hexagonal Nanosheets: Multi-enzyme and Ultrasound Catalysis for Synergistic Anticancer Treatment

Defect-Rich Ni–CoO@PEG Porous Hexagonal Nanosheets: Multi-enzyme and Ultrasound Catalysis for Synergistic Anticancer Treatment

An erythrocyte membrane-modified biomimetic synergistic nanosystem for cancer anti-vascular therapy and initial efficacy monitoring

Engineered Enzyme-Loaded Erythrocyte Vesicles Precisely Deprive Tumoral Nutrients to Induce Synergistic Near-Infrared-II Photothermal Therapy and Immune Activation

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