Tumor microenvironment and breast cancer progression

Artacho-Cordón, Antonia; Artacho‐Cordón, Francisco; Ríos‐Arrabal, Sandra; Calvente, Irene; Núñez, María Isabel

doi:10.4161/cbt.13.1.18869

Cited by 45 publications

(37 citation statements)

References 134 publications

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“…In vivo and in vitro experimental studies found that PCB-mediated ROS production would induce invasiveness and metastasis by activating Rho-Associated Kinase (ROCK) activity (Liu et al, 2010). It has also been demonstrated that some POPs interfere with certain matrix metalloproteinases (Kim et al, 2011) that can disrupt E-cadherin intercellular junctions (Artacho-Cordon et al, 2012).…”

Section: Discussionmentioning

confidence: 97%

Associations of persistent organic pollutants in serum and adipose tissue with breast cancer prognostic markers

Arrebola

Fernández-Rodríguez

Artacho‐Cordón

et al. 2016

Science of The Total Environment

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Section: Discussionmentioning

confidence: 97%

Associations of persistent organic pollutants in serum and adipose tissue with breast cancer prognostic markers

Arrebola

Fernández-Rodríguez

Artacho‐Cordón

et al. 2016

Science of The Total Environment

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“…We now know that the tumor microenvironment is the main regulator of carcinogenesis and is responsible for the course of tumor progression, including how tumors respond to various types of treatment [24,25] . The development and progression of a tumor to a malignant phenotype is highly dependent on interactions between the tumor cells and normal cells present in the tumor microenvironment [23,26] . There are extensive changes in genetic expression in all cell types during BC progression.…”

Section: The Evolution Of Malignant Breast Tumors Beings Withmentioning

confidence: 99%

“…Concomitantly, tumor cells in the stroma produce proteolytic enzymes; while chemokines and cytokines continue to attract leukocytes, modulate tumor remodeling, and facilitate tumor cell invasion of distant organs, leading to metastasis. Infiltrating fibroblasts and leukocytes are induced to increase the secretion of growth factors, cytokines, chemokines and matrix metalloproteinases (MMPs) which produce an immune-evasion mechanism that enables the tumor to progress and achieve angiogenesis [23] . We now know that the tumor microenvironment is the main regulator of carcinogenesis and is responsible for the course of tumor progression, including how tumors respond to various types of treatment [24,25] .…”

Section: The Evolution Of Malignant Breast Tumors Beings Withmentioning

confidence: 99%

Pattern response of dendritic cells in the tumor microenvironment and breast cancer

Cunha

Michelin

Murta

2014

WJCO

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Breast cancer (BC) is the most common malignant neoplasm and the cause of death by cancer among women worldwide. Its development, including malignancy grade and patient prognosis, is influenced by various mutations that occur in the tumor cell and by the immune system's status, which has a direct influence on the tumor microenvironment and, consequently, on interactions with non-tumor cells involved in the immunological response. Among the immune response cells, dendritic cells (DCs) play a key role in the induction and maintenance of anti-tumor responses owing to their unique abilities for antigen cross-presentation and promotion of the activation of specific lymphocytes that target neoplasic cells. However, the tumor microenvironment can polarize DCs, transforming them into immunosuppressive regulatory DCs, a tolerogenic phenotype which limits the activity of effector T cells and supports tumor growth and progression. Various factors and signaling pathways have been implicated in the immunosuppressive functioning of DCs in cancer, and researchers are working on resolving processes that can circumvent tumor escape and developing viable therapeutic interventions to prevent or reverse the expression of immunosuppressive DCs in the tumor microenvironment. A better understanding of the pattern of DC response in patients with BC is fundamental to the development of specific therapeutic approaches to enable DCs to function properly. Various studies examining DCs immunotherapy have demonstrated its great potential for inducing immune responses to specific antigens and thereby reversing immunosuppression and related to clinical response in patients with BC. DCbased immunotherapy research has led to immense scientific advances, both in our understanding of the antitumor immune response and for the treatment of these patients.© 2014 Baishideng Publishing Group Inc. All rights reserved. Key words: Breast cancer; Dendritic cells; Tumor microenvironmentCore tip: Breast cancer is a worldwide major public health problem, and dendritic cells are of crucial importance for activating an effective antitumor immune response. Deepening our understanding of the tumor microenvironment can enable the development of new therapies that will make it possible to induce an efficacious antitumor response. Given the search for effective means with which to induce such a response via dendritic cell (DC) immunotherapy, the study of the mechanisms involved in the DC pattern of response in the tumor microenvironment is important.

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“…Mesenchymal stromal cells (MSCs) and their derivatives localize to tumor sites and are major cellular compartments of tumor microenvironments 1,2. Despite extensive studies, the effects and mechanisms of MSCs in tumor invasion and metastasis are not fully understood.…”

mentioning

confidence: 99%

Mesenchymal Stromal Cells Promote Tumor Progression in Fibrosarcoma and Gastric Cancer Cells

et al. 2014

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BackgroundExtensive evidence has accumulated regarding the role of mesenchymal stromal cells (MSCs) in tumor progression, but the exact effects and mechanisms underlying this role remain unclear. We investigated the effects of MSC-associated tumor progression in MSC-sarcoma models and a gastric cancer metastatic model.MethodsWe conducted an in vitro growth kinetics assay and an in vivo tumor progression assay for sarcoma cells and gastric cancer cells in the presence or absence of MSCs.ResultsMSC-cocultured human fibrosarcoma cells (HT1080) showed accelerated growth compared with HT1080 alone (79- vs 37-fold change, p<.050). For HT1080, human MSC-coinjected tumors showed significantly greater and highly infiltrative growth compared to those of HT1080 alone (p=.035). For mouse fibrosarcoma cells (WEHI164), mouse MSC-coinjected tumors had greater volume than those of WEHI164 alone (p=.141). For rat sarcoma cells (RR1022), rat MSC-coinjected tumors exhibited greater volume and infiltrative growth than those of RR1022 alone (p=.050). For human gastric cancer cells (5FU), tumors of 5FU alone were compact, nodular in shape, and expansile with good demarcation and no definite lung metastatic nodules, whereas tumors grown in the presence of human MSCs showed highly desmoplastic and infiltrative growth and multiple lung metastasis.ConclusionsWe observed morphological evidence for MSC-associated tumor progression of fibrosarcomas and gastric cancer cells.

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Tumor microenvironment and breast cancer progression

Cited by 45 publications

References 134 publications

Associations of persistent organic pollutants in serum and adipose tissue with breast cancer prognostic markers

Associations of persistent organic pollutants in serum and adipose tissue with breast cancer prognostic markers

Pattern response of dendritic cells in the tumor microenvironment and breast cancer

Mesenchymal Stromal Cells Promote Tumor Progression in Fibrosarcoma and Gastric Cancer Cells

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