Tumor microenvironment components: Allies of cancer progression

Franco, Pablo Igor Ribeiro; Rodrigues, Aline Sueli de Lima; Menezes, Liliana Borges de; Miguel, Marina Pacheco

doi:10.1016/j.prp.2019.152729

Cited by 166 publications

(101 citation statements)

References 103 publications

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“…The angiogenic process depending on the coordination of many factors is present in the tumor microenvironment and, therefore, understanding the interactions between these components is also Tumor cells, together with inflammatory stromal cells, provide bioactive molecules, such as cytokines, chemokines, and other factors to the tumor microenvironment. This creates an immunosuppressive phenotype to favor its proliferation, survival, and angiogenesis [1,17]. The angiogenic process depending on the coordination of many factors is present in the tumor microenvironment and, therefore, understanding the interactions between these components is also relevant for therapeutic strategies against cancer [18,19].…”

Section: Biological Evaluationmentioning

confidence: 99%

Antitumor Effect of a Novel Spiro-Acridine Compound is Associated with Up-Regulation of Th1-Type Responses and Antiangiogenic Action

et al. 2019

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Tumor cells have specific features, including angiogenesis induction, cell cycle dysregulation, and immune destruction evasion. By inducing a T helper type 2 (Th2) immune response, tumor cells may favor immune tolerance within the tumor, which allows progression of cancer growth. Drugs with potential antitumor activity are the spiro-acridines, which is a promising new class of acridine compounds. Herein, the novel spiro-acridine (E)-5 -oxo-1 -((3,4,5-trimethoxybenzylidene)amino)-1 ,5 -dihydro-10H-spiro[acridine-9,2 -pyrrole]-4 -carbonitrile (AMTAC-17) was synthesized and tested for antitumor effects. Toxicity evaluation was performed in mice after acute treatment (2000 mg/kg, intraperitoneally, i.p.). The Ehrlich ascites carcinoma model was used to investigate the antitumor activity of AMTAC-17 (12.5, 25, or 50 mg/kg, i.p.) after seven days of treatment. Effects on the cell cycle, angiogenesis, and inflammatory responses were investigated. LD 50 (lethal dose 50%) was estimated to be higher than 5000 mg/kg. AMTAC-17 reduced the Ehrlich tumor's total viable cancer cells count and peritumoral micro-vessels density, and induced an increase in the sub-G1 peak. Additionally, there was an increase of Th1 cytokine profile levels (IL-1β, TNF-α, and IL-12). In conclusion, the spiro-acridine compound AMTAC-17 presents low toxicity, and its in vivo antitumor effect involves modulation of the immune system to a cytotoxic Th1 profile and a reduction of tumor angiogenesis.

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Section: Biological Evaluationmentioning

confidence: 99%

Antitumor Effect of a Novel Spiro-Acridine Compound is Associated with Up-Regulation of Th1-Type Responses and Antiangiogenic Action

et al. 2019

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“…Although the immune system can elicit an antitumor response that leads to tumor destruction in some cases, the successful development of such a response is often hampered by a plethora of factors. Indeed, immune cell populations are conditioned by soluble factors, enzymes and metabolites produced by nearby tumor and stromal cells within the tumor microenvironment (TME) that contribute to dampen the antitumor immune response [4]. Moreover, the immunosuppressive TME can even shape immune cell functions toward a tumor-promoting response [5].…”

Section: Introductionmentioning

confidence: 99%

Shaping the Innate Immune Response by Dietary Glucans: Any Role in the Control of Cancer?

Cornò

Gessani

Conti

2020

Cancers

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β-glucans represent a heterogeneous group of naturally occurring and biologically active polysaccharides found in many kinds of edible mushrooms, baker’s yeast, cereals and seaweeds, whose health-promoting effects have been known since ancient times. These compounds can be taken orally as food supplements or as part of daily diets, and are safe to use, nonimmunogenic and well tolerated. A main feature of β-glucans is their capacity to function as biological response modifiers, exerting regulatory effects on inflammation and shaping the effector functions of different innate and adaptive immunity cell populations. The potential to interfere with processes involved in the development or control of cancer makes β-glucans interesting candidates as adjuvants in antitumor therapies as well as in cancer prevention strategies. Here, the regulatory effects of dietary β-glucans on human innate immunity cells are reviewed and their potential role in cancer control is discussed.

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“…These modifications lead to sustained proliferative signaling, evasion from growth suppressors and cell death, replicative immortality, and induction of angiogenesis, invasion, and metastasis [1,2]. Malignant tumors are characterized by high cellular heterogeneity, including cancerous and non-cancerous cells, and non-cellular components, composing the tumor microenvironment (TME) [3]. Malignant cells can recruit stromal cells to remodel tissue structure and to secrete growth-promoting stimuli and intermediate metabolites.…”

Section: Introductionmentioning

confidence: 99%

“…Malignant cells can recruit stromal cells to remodel tissue structure and to secrete growth-promoting stimuli and intermediate metabolites. As a result, stromal components (e.g., fibroblasts, endothelial cells, and pericytes) contribute to multiple processes of tumorigenesis, which include tumor growth, invasion, metastasis, and therapy resistance [3,4].…”

Section: Introductionmentioning

confidence: 99%

The Role of Cancer-Associated Fibroblasts and Extracellular Vesicles in Tumorigenesis

Shoucair

Mello

Jabalee

et al. 2020

IJMS

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Extracellular vesicles (EVs) play a key role in the communication between cancer cells and stromal components of the tumor microenvironment (TME). In this context, cancer cell-derived EVs can regulate the activation of a CAF phenotype in TME cells, which can be mediated by several EV cargos (e.g., miRNA, proteins, mRNA and lncRNAs). On the other hand, CAF-derived EVs can mediate several processes during tumorigenesis, including tumor growth, invasion, metastasis, and therapy resistance. This review aimed to discuss the molecular aspects of EV-based cross-talk between CAFs and cancer cells during tumorigenesis, in addition to assessing the roles of EV cargo in therapy resistance and pre-metastatic niche formation.

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Tumor microenvironment components: Allies of cancer progression

Cited by 166 publications

References 103 publications

Antitumor Effect of a Novel Spiro-Acridine Compound is Associated with Up-Regulation of Th1-Type Responses and Antiangiogenic Action

Antitumor Effect of a Novel Spiro-Acridine Compound is Associated with Up-Regulation of Th1-Type Responses and Antiangiogenic Action

Shaping the Innate Immune Response by Dietary Glucans: Any Role in the Control of Cancer?

The Role of Cancer-Associated Fibroblasts and Extracellular Vesicles in Tumorigenesis

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