Tumor Microenvironment Mediators CD8+- and FOXP3+-Labeled T Lymphocytes Are Prospective Prognosticators in Curatively Treated Rectal Cancer Patients

Zaghloul, Hala; Abbas, Ahmed M.; Abdulah, Dina

doi:10.1007/s12029-020-00376-1

Cited by 5 publications

(4 citation statements)

References 28 publications

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“…Yang et al observed that a high baseline influx of CD8 + T cells in rectal cancers was significantly associated with pCR 31 . This has also been reported in studies of CRC 10 , 11 , 32–34 . In contrast, other studies have not found a significant correlation between TIL density in pre-operative biopsies and tumor shrinkage after neoadjuvant treatment 12 , 35 .…”

Section: Discussionmentioning

confidence: 76%

A type I interferon footprint in pre-operative biopsies is an independent biomarker that in combination with CD8 ⁺ T cell quantification can improve the prediction of response to neoadjuvant treatment of rectal adenocarcinoma

et al. 2023

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Tailored treatment for patients with rectal cancer requires clinically available markers to predict their response to neoadjuvant treatment. The quantity of tumor-infiltrating lymphocytes (TILs) in pre-operative tumor biopsies has been suggested to predict a favorable response, but opposing results exist. A biopsy-adapted Immunoscore (IS B ) based on TILs has recently emerged as a promising predictor of tumor regression and prognosis in (colo)rectal cancer. We aimed to refine the IS B for prediction of response using multiplex immunofluorescence (mIF) on pre-operative rectal cancer biopsies. We combined the distribution and density of conventional T cell subsets and γδT cells with a type I Interferon (IFN)-driven response assessed using Myxovirus resistance protein A (MxA) expression. We found that pathological complete response (pCR) following neoadjuvant treatment was associated with type I IFN. Stratification of patients according to the density of CD8 + in the entire tumor tissue and MxA + cells in tumor stroma, where equal weight was assigned to both parameters, resulted in improved predictive quality compared to the IS B . This novel stratification approach using these two independent parameters in pre-operative biopsies could potentially aid in identifying patients with a good chance of achieving a pCR following neoadjuvant treatment.

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Section: Discussionmentioning

confidence: 76%

A type I interferon footprint in pre-operative biopsies is an independent biomarker that in combination with CD8 ⁺ T cell quantification can improve the prediction of response to neoadjuvant treatment of rectal adenocarcinoma

et al. 2023

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“…Infiltration of CD8 + T cells can reduce tumor cell metastasis and is associated with higher survival rate and lower risk of recurrence in patients with biliary tract cancer. [ 19 , 27 ] High FoxP3 + Tregs/CD8 + T cell value was found to be associated with poor OS and disease-free survival in lung adenocarcinoma, pancreatic cancer and other tumors. [ 28 , 29 ] It can be seen that the increase of FoxP3 + Tregs infiltration and the decrease of CD8 + T cell infiltration contribute to the formation of immunosuppressive TME and lead to poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

The prognostic value of Forkhead box P3 regulatory T cells in biliary tract cancer: A systematic review and meta-analysis

Cai,

Wu,

Yang

et al. 2023

Medicine

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Background: This study aimed to explore the value of tumor-infiltrating Forkhead box P3(FoxP3+) regulatory T cells (Tregs) in evaluating the prognosis of biliary tract cancer. Methods: Four electronic databases were searched using 2 computers: PubMed, Embase, Web of Science, and Cochrane Library. The vocabulary and syntax were adapted according to the database. Two researchers independently selected the studies, collected information, and assessed the risk of bias. The Meta-analysis was performed using STATA 17.0, and HR and its corresponding 95% CI were used to evaluate the correlation between FoxP3+ Tregs and the overall survival of patients with biliary tract cancer. In addition, the quality of the included studies was evaluated. Results: Ten articles were included in this study. The results of the meta-analysis showed that patients with high FoxP3+ Tregs infiltration had worse overall survival (OS) (HR = 1.34,95% CI 1.16 to 1.71; P < .001). Subgroup analysis of gallbladder carcinoma and cholangiocarcinoma showed that the high infiltration of FoxP3+ Tregs was significantly correlated with the OS of the former (HR = 1.55,95% CI 1.11 to 2.00; P < .001), but not with the OS of the latter (HR = 1.00,95% CI 0.62 to 1.38; P > .05). Conclusions: Our meta-analysis reveals that high infiltration of FoxP3 + Tregs is significantly associated with reduced overall survival in gallbladder carcinoma, endorsing their use as a prognostic biomarker for this subtype. In contrast, no significant prognostic correlation was identified for FoxP3+ Tregs in cholangiocarcinoma, indicating the need for subtype-specific evaluation of their prognostic relevance in biliary tract cancers.

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“…On the other hand, Mcoy et al [40] found no association between any T-cell subpopulation (CD3+, CD8+ or FOXP3+) and response to neoadjuvant treatment, while FOXP3+ T-cells appeared to be inversely related to therapeutic outcome in a different study [41]. Similarly, rectal cancer patients with a lower infiltration of FOXP3+ T-cells in pretreatment biopsies responded better to neoadjuvant chemoradiation and had better prognosis [42].…”

Section: Prognostic Relevancementioning

confidence: 95%

Immune Response and Immune Checkpoint Molecules in Patients with Rectal Cancer Undergoing Neoadjuvant Chemoradiotherapy: A Review

Koukourakis

Platoni

Tiniakos

et al. 2023

CIMB

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It is well-established that tumor antigens and molecules expressed and secreted by cancer cells trigger innate and adaptive immune responses. These two types of anti-tumor immunity lead to the infiltration of the tumor’s microenvironment by immune cells with either regulatory or cytotoxic properties. Whether this response is associated with tumor eradication after radiotherapy and chemotherapy or regrowth has been a matter of extensive research through the years, mainly focusing on tumor-infiltrating lymphocytes and monocytes and their subtypes, and the expression of immune checkpoint and other immune-related molecules by both immune and cancer cells in the tumor microenvironment. A literature search has been conducted on studies dealing with the immune response in patients with rectal cancer treated with neoadjuvant radiotherapy or chemoradiotherapy, assessing its impact on locoregional control and survival and underlying the potential role of immunotherapy in the treatment of this cancer subtype. Here, we provide an overview of the interactions between local/systemic anti-tumor immunity, cancer-related immune checkpoint, and other immunological pathways and radiotherapy, and how these affect the prognosis of rectal cancer patients. Chemoradiotherapy induces critical immunological changes in the tumor microenvironment and cancer cells that can be exploited for therapeutic interventions in rectal cancer.

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Tumor Microenvironment Mediators CD8+- and FOXP3+-Labeled T Lymphocytes Are Prospective Prognosticators in Curatively Treated Rectal Cancer Patients

Cited by 5 publications

References 28 publications

A type I interferon footprint in pre-operative biopsies is an independent biomarker that in combination with CD8 ⁺ T cell quantification can improve the prediction of response to neoadjuvant treatment of rectal adenocarcinoma

A type I interferon footprint in pre-operative biopsies is an independent biomarker that in combination with CD8 ⁺ T cell quantification can improve the prediction of response to neoadjuvant treatment of rectal adenocarcinoma

The prognostic value of Forkhead box P3 regulatory T cells in biliary tract cancer: A systematic review and meta-analysis

Immune Response and Immune Checkpoint Molecules in Patients with Rectal Cancer Undergoing Neoadjuvant Chemoradiotherapy: A Review

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Tumor Microenvironment Mediators CD8+- and FOXP3+-Labeled T Lymphocytes Are Prospective Prognosticators in Curatively Treated Rectal Cancer Patients

Cited by 5 publications

References 28 publications

A type I interferon footprint in pre-operative biopsies is an independent biomarker that in combination with CD8 + T cell quantification can improve the prediction of response to neoadjuvant treatment of rectal adenocarcinoma

A type I interferon footprint in pre-operative biopsies is an independent biomarker that in combination with CD8 + T cell quantification can improve the prediction of response to neoadjuvant treatment of rectal adenocarcinoma

The prognostic value of Forkhead box P3 regulatory T cells in biliary tract cancer: A systematic review and meta-analysis

Immune Response and Immune Checkpoint Molecules in Patients with Rectal Cancer Undergoing Neoadjuvant Chemoradiotherapy: A Review

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A type I interferon footprint in pre-operative biopsies is an independent biomarker that in combination with CD8 ⁺ T cell quantification can improve the prediction of response to neoadjuvant treatment of rectal adenocarcinoma

A type I interferon footprint in pre-operative biopsies is an independent biomarker that in combination with CD8 ⁺ T cell quantification can improve the prediction of response to neoadjuvant treatment of rectal adenocarcinoma