Tumor microenvironment of cancer stem cells: Perspectives on cancer stem cell targeting

Guo, Qianqian; Zhou, Yi; Xie, Tianyuan; Yin, Yuan; Li, Huilong; Shi, Wanjin; Zheng, Lufeng; Li, Xiaoman; Zhang, Wenzhou

doi:10.1016/j.gendis.2023.05.024

Cited by 6 publications

(2 citation statements)

References 323 publications

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“…Cancer stem-like cells (CSLCs) possess stem-like characteristics in tumor tissues, including self-renewal, differentiation, and high-efficiency tumorigenesis. CSLCs have been identified in various types of tumors such as liver cancer, esophageal cancer, and colorectal cancer [ 19 ]. The regulatory mechanisms of CSLCs have been gradually revealed in these tumors.…”

Section: Discussionmentioning

confidence: 99%

Expressions and Clinical Significance of Met and YAP in Gastric Cancer Tissue Microarray

Li,

Zhang,

Liu

et al. 2024

Gastroenterology Research and Practice

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Objective. This study is aimed at investigating the expression of Met and YAP in gastric cancer and their impact on clinical prognosis. Methods. Tissue samples and clinical data were collected from 89 patients with gastric cancer. Immunohistochemistry was performed to quantify the expression of Met and YAP using tissue microarray. The correlation between the expressions of Met, YAP, and clinicopathological characteristics of patients was determined using a chi-square test. Survival analysis was conducted using the Kaplan-Meier method, while multivariate survival analysis was performed using the Cox proportional hazard model. Bioinformatics analysis was carried out by downloading chip data from TCGA. Results. The expression levels of both Met and YAP were significantly higher in gastric cancer tissues compared to adjacent tissues (P<0.001). Met expression showed a positive association with P53 and CD133, whereas YAP expression correlated positively with tumor grade and CD133 (P<0.05). Pearson’s analysis revealed a significant correlation between Met expression and VEGFR as well as CD133, while YAP expression correlated with Ki67 and VEGFR (P<0.05). Patients with high levels of both Met and YAP exhibited decreased survival time (P<0.01). Furthermore, Met expression, N stage, and VEGFR were identified as independent risk factors for gastric cancer prognosis (P<0.05), whereas no such association was observed for YAP expression. Bioinformatics analysis demonstrated a significant correlation between the expressions of Met and YAP; both proteins were highly expressed in gastric cancer patients accompanied by markedly reduced survival time. Conclusion. The expressions of Met and YAP are closely associated with the survival outcomes as well as clinicopathological features in patients with gastric cancer. Moreover, our findings highlight that Met serves as an independent prognostic factor for gastric cancer.

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Section: Discussionmentioning

confidence: 99%

Expressions and Clinical Significance of Met and YAP in Gastric Cancer Tissue Microarray

Li,

Zhang,

Liu

et al. 2024

Gastroenterology Research and Practice

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“…Cancer stem cells (CSCs) possess self-renewal, infinite cell proliferation, and metastasis capacity, which are the properties that cause cancer to be heterogenous and make cancer treatment challenging [6][7][8]. In recent years, CSCs have been shown to exist in a variety of solid tumors, including colon, breast, lung, liver, prostate tumors, and many other malignant cancers [9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Silencing LY6D Expression Inhibits Colon Cancer in Xenograft Mice and Regulates Colon Cancer Stem Cells’ Proliferation, Stemness, Invasion, and Apoptosis via the MAPK Pathway

Duan,

Wang,

Chen

et al. 2023

Molecules

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This study explored the role of lymphocyte antigen 6 family member D (LY6D) in colon cancer stem cells’ (CCSCs) proliferation and invasion. LY6D was knocked down using siRNA, and the down-regulation of LY6D was verified using Western blotting. After LY6D knockdown, CCSCs’ proliferation, stemness, and invasion were suppressed, whereas apoptosis was increased. Gene Ontology (GO) enrichment analysis revealed that the differentially expressed genes (DEGs) between siLY6D and the negative control groups were significantly enriched in the cell–substrate adherens junction, focal adhesion, and cell–substrate junction terms. Meanwhile, the Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis revealed that the DEGs were significantly enriched in the MAPK pathway. In addition, Western blotting results showed that pBRAF and pERK1/2, cascade kinases of the MAPK pathway, were significantly down-regulated after LY6D knockdown. In addition, nude mice xenograft experiments showed that the siLY6D treatment decreased tumor sizes and weights and improved tumor-bearing mice survival rates compared with the control group. In conclusion, these findings indicate that LY6D, which is highly expressed in CCSCs, is a key factor involved in tumor growth and development and might be a potential cancer marker and therapeutic target for colon cancer.

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Stemness regulation in prostate cancer: prostate cancer stem cells and targeted therapy

Liang,

Zhou,

et al. 2024

Annals of Medicine

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Tumor microenvironment of cancer stem cells: Perspectives on cancer stem cell targeting

Cited by 6 publications

References 323 publications

Expressions and Clinical Significance of Met and YAP in Gastric Cancer Tissue Microarray

Expressions and Clinical Significance of Met and YAP in Gastric Cancer Tissue Microarray

Silencing LY6D Expression Inhibits Colon Cancer in Xenograft Mice and Regulates Colon Cancer Stem Cells’ Proliferation, Stemness, Invasion, and Apoptosis via the MAPK Pathway

Stemness regulation in prostate cancer: prostate cancer stem cells and targeted therapy

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