Tumor microenvironment-oriented MOFs for chemodynamic therapy

Current status and prospects of MIL-based MOF materials for biomedicine applications

“…6, CDT is a new cancer treatment strategy that uses Fenton reactions to convert intracellular hydrogen peroxide into highly toxic hydroxyl radicals (˙OH) to kill cancer cells. 48,49 CDT demonstrates minimal invasiveness and high tumor specificity by reacting with the acidic and high-concentration hydrogen peroxide microenvironment in tumors, reducing systemic toxicity and providing better therapeutic effects and biocompatibility. 50 CDT is less dependent on external stimuli, simplifying the treatment process, and can regulate the hypoxic and immunosuppressive states in the tumor microenvironment, showing great application prospects.…”

An oxygen-generating metal organic framework nanoplatform as a “synergy motor” for extricating dilemma over photodynamic therapy

“…MOFs commonly reveal a pH-responsive property in the tumor microenvironment, ascribed to the weakly acidic nature of the tumor microenvironment and the central metal ions of the MOFs, which were favorable to expedite the decomposition of MOFs under acidic conditions and attain satisfactory drug release effects. 104 For instance, Chen et al 105 constructed a pH-responsive zeolitic imidazolate framework-8-polyacrylic acid (ZIF-8-PAA) material encapsulating a broad-spectrum photosensitizer antibacterial agent ammonium methylbenzene blue (MB) for bacterial infection. The results have demonstrated that MB was released faster in MES buffer (pH 5.5) than in PBS buffer (pH 7.4), exhibiting an obvious pH-responsive property.…”

“…MOFs commonly reveal a pH-responsive property in the tumor microenvironment, ascribed to the weakly acidic nature of the tumor microenvironment and the central metal ions of the MOFs, which were favorable to expedite the decomposition of MOFs under acidic conditions and attain satisfactory drug release effects. 104 For instance, Chen et al 105 constructed a pH-responsive zeolitic imidazolate framework-8-polyacrylic acid (ZIF-8-PAA) material…”

Photonic Crystals Based on ZIF-8 Nanoparticles with Embedded Carbon Dots for Optical Information Encryption

“…Metal–organic frameworks (MOFs) are heterogeneous microporous crystalline materials formed by metal ions/clusters with organic ligands and have been widely used in diverse applications such as chemical separation, photocatalysis, fuel cells, sensing, , and molecular transport . Recently, due to the outstanding advantages of MOFs, including tunable shape, large pore size, and porous structure, they have been used as chemical substances loading materials for chemodynamic therapy, nanocatalytic medicine, and drug delivery system . Recently, the encapsulation of fluorescent substances into MOFs has received much attention.…”