Tumor microenvironment-responsive nanosystem achieves reactive oxygen species self-cycling after photothermal induction to enhance efficacy of antitumor therapy

Peng, Yuting; Cheng, Lianghao; Luo, Chunyi; Xiong, Fuquan; Wu, Zhongbiao; Zhang, Lin; Zhan, Peng; Shao, Lishu; Luo, Wenjie

doi:10.1016/j.cej.2023.142370

Cited by 10 publications

(3 citation statements)

References 63 publications

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“…Very recently, Luo's team reported a traceable, ROS-responsive nanosystem for integrated chemotherapy/PTT/PDT, which was self-assembled by an IR825-bonded Nisopropylacrylamide modified lignin (MND-IR) and a natural plant antitoxin compound resveratrol (RESV) (MND-IR@RESV) [91]. The MNDIR@RESV micelles could release RESV at the tumor site in response to NIR irradiation, which induced the photothermal conversion of IR825 and the hydrophilic to hydrophobic transition of PNIPAM chains for the disintegration of the micelles into flocculent insoluble substances.…”

Section: Tme-responsive Drug Release For Enhanced Pdt/ptt/chemotherapymentioning

confidence: 99%

Recent Advances of Tumor Microenvironment-Responsive Nanomedicines-Energized Combined Phototherapy of Cancers

Liu,

Yao,

Xue

et al. 2023

Pharmaceutics

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Photodynamic therapy (PDT) has emerged as a powerful tumor treatment tool due to its advantages including minimal invasiveness, high selectivity and thus dampened side effects. On the other side, the efficacy of PDT is severely frustrated by the limited oxygen level in tumors, thus promoting its combination with other therapies, particularly photothermal therapy (PTT) for bolstered tumor treatment outcomes. Meanwhile, nanomedicines that could respond to various stimuli in the tumor microenvironment (TME) provide tremendous benefits for combined phototherapy with efficient hypoxia relief, tailorable drug release and activation, improved cellular uptake and intratumoral penetration of nanocarriers, etc. In this review, we will introduce the merits of combining PTT with PDT, summarize the recent important progress of combined phototherapies and their combinations with the dominant tumor treatment regimen, chemotherapy based on smart nanomedicines sensitive to various TME stimuli with a focus on their sophisticated designs, and discuss the challenges and future developments of nanomedicine-mediated combined phototherapies.

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Section: Tme-responsive Drug Release For Enhanced Pdt/ptt/chemotherapymentioning

confidence: 99%

Recent Advances of Tumor Microenvironment-Responsive Nanomedicines-Energized Combined Phototherapy of Cancers

Liu,

Yao,

Xue

et al. 2023

Pharmaceutics

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“…Furthermore, ligninco-gelatin cryogel still possessed abilities for scavenge free radicals and good cytocompatibility, which was very promising for a wide range of biomedical applications. Recently, our groups [121] developed a new traceable, specifically targeted nanosystem for antitumor therapy (Figure 17). A nanosystem (MND-IR@RESV) consisted of IR825 bonded N-isopropylacrylamide modified lignin (MND-IR) and RESV encapsulated.…”

Section: Biomedical Materialsmentioning

confidence: 99%

Functional Lignin‐based Polymers: Isolation, Synthetic Methods and High‐valued Applications

Shao,

Liu,

Wang

et al. 2023

ChemistrySelect

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As a major component of lignocellulosic biomass, lignin has lots of fascinating properties, such as regeneration, biocompatibility, antioxidant, hydrophilicity, unique aromatic structure, and various functional groups, which make them become interesting natural polymer raw material, and attracted more and more attention. In particular, the rich functional groups of lignin can be easily functionalized through various synthesis methods, which can endow lignin‐based polymers with new structure and function. These functional lignin‐based polymers are widely used in environmental remediation, smart hydrogel materials, catalysis, biomedical, etc. However, its various sources and types, the complex structure, relatively weak chemical reactivity, the unstable processing property, and few high value‐added products limited their practical applications. With the development of lignin varieties, modified reagent, synthesis methods, and polymerization process, many works had been published for the synthesis and application of lignin‐based polymers. In this review, the lignin isolation, modification strategies, polymerization method and process, and the promising applications were summarized and analyzed in recent years. Specially, the recent advances in the preparation of high excellent adsorbents from deconstructed lignin products are highlighted from the synthesis methods and adsorption mechanism perspective. Finally, we discussed these challenges in the green and controllable synthesis of lignin‐based polymers, and prospected their functional applications.

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“…21 To overcome this disadvantage, other therapeutic modalities such as chemotherapy and immunotherapy are commonly chosen to combine with PTT, and such a combination strategy has been proven as an efficient approach to improve the therapeutic efficacy. 22,23 As the process of CDT is eventually a kind of chemical reaction, it may be accelerated at high temperature, which can be provided by the PTT process. 24 On the other hand, OH can deactivate overexpressed heat-shock proteins (HSPs), which can suppress the PTT efficacy, during the PTT process.…”

Section: Introductionmentioning

confidence: 99%

Iron-chelated semiconducting oligomer nanoparticles for NIR-II fluorescence imaging-guided enhanced chemodynamic/photothermal combination therapy

Diao,

Shi,

Liu

et al. 2023

J. Mater. Chem. B

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Tumor microenvironment-responsive nanosystem achieves reactive oxygen species self-cycling after photothermal induction to enhance efficacy of antitumor therapy

Cited by 10 publications

References 63 publications

Recent Advances of Tumor Microenvironment-Responsive Nanomedicines-Energized Combined Phototherapy of Cancers

Recent Advances of Tumor Microenvironment-Responsive Nanomedicines-Energized Combined Phototherapy of Cancers

Functional Lignin‐based Polymers: Isolation, Synthetic Methods and High‐valued Applications

Iron-chelated semiconducting oligomer nanoparticles for NIR-II fluorescence imaging-guided enhanced chemodynamic/photothermal combination therapy

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