Tumor models for efficacy determination

Teicher, Beverly A.

doi:10.1158/1535-7163.mct-06-0391

Cited by 177 publications

(129 citation statements)

References 74 publications

Supporting

Mentioning

128

Contrasting

Order By: Relevance

“…These have included subcutaneous xenografts, or orthotopic injections, and transgenic or genetically engineered mice (Teicher 2006). Subcutaneous implantation of thyroid cancer cells into nude mice or NOD/SCID mice has been most commonly used to study CSCs.…”

Section: Animal Models Used In Csc Studiesmentioning

confidence: 99%

Cancer stem-like cells and thyroid cancer

Guo¹,

Hardin²,

Lloyd³

2014

Endocrine Related Cancer

View full text Add to dashboard Cite

Thyroid cancer is one of the most rapidly increasing malignancies. The reasons for this increase is not completely known, but increases in the diagnosis of papillary thyroid microcarcinomas and follicular variant of papillary thyroid carcinomas along with the enhanced detection of well-differentiated thyroid carcinomas are probably all contributing factors. Although most cases of well-differentiated thyroid carcinomas are associated with an excellent prognosis, a small percentage of patients with well-differentiated thyroid carcinomas as well as most patients with poorly differentiated and anaplastic thyroid carcinomas have recurrent and/or metastatic disease that is often fatal. The cancer stem-like cell (CSC) model suggests that a small number of cells within a cancer, known as CSCs, are responsible for resistance to chemotherapy and radiation therapy, as well as for recurrent and metastatic disease. This review discusses current studies about thyroid CSCs, the processes of epithelial-to-mesenchymal transition (EMT), and mesenchymal-to-epithelial transition that provide plasticity to CSC growth, in addition to the role of microRNAs in CSC development and regulation. Understanding the biology of CSCs, EMT and the metastatic cascade should lead to the design of more rational targeted therapies for highly aggressive and fatal thyroid cancers.

show abstract

Section: Animal Models Used In Csc Studiesmentioning

confidence: 99%

Cancer stem-like cells and thyroid cancer

Guo¹,

Hardin²,

Lloyd³

2014

Endocrine Related Cancer

View full text Add to dashboard Cite

show abstract

“…They are produced by injecting human tumor cell lines (most often), or pieces of primary human tumors (less often), sub cutaneously, in the peritoneal cavity, or occasion ally in orthotopic sites of immune compromised mice ( Figure 2). 32 Drugs can be evaluated for their effects on tumor growth or regression using direct measurement of tumor volume or imaging techniques. [33][34][35] Although many human cell lines will generate tumors, the number of cell lines that can be tested in xenograft studies is limited, largely for logistic reasons, and frequently they do not recapitu late the broad range of molecular transformation events in human tumors.…”

Section: Xenograft Modelsmentioning

confidence: 99%

Preclinical development of molecular-targeted agents for cancer

et al. 2010

View full text Add to dashboard Cite

“…Orthotopic implantations make organotypical interactions between the microenvironment, where the tumour develops, and the tumour cells possible [86,87]. Successively passaged PDXs display biological similarity with the native tumour, as evidenced by genomic, proteomic, transcriptomic and histological analysis [70,75,[88][89][90][91][92].…”

Section: In Vivo Cancer Modelsmentioning

confidence: 99%