Tumor necrosis factor-alpha blockade with etanercept improves autonomic dysfunction in rheumatoid arthritis

Syngle, Ashit; Ic, Verma; Krishan, Pawan; Chahal, S.M.S.; Syngle, Vijaita

doi:10.15305/ijrci/v4i1/198

Cited by 1 publication

(1 citation statement)

References 9 publications

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“…2 Imbalance in the ANS has been observed in many established chronic autoimmune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and psoriatic arthritis (PsA). 2,3 Satisfying information is absent regarding ANS involvement in patients with AS. Th e literature about ANS dysfunction in AS patients revealed confl icting results, some of them showing disturbance of parasympathetic system.…”

Section: Introductionmentioning

confidence: 99%

Ankilozan Spondilit'te Otonomik Disfonksiyon Hastalık Sürecinin Bir İşareti midir? Bir Elektrofizyolojik Çalışma

Keskin

Gümüşsu

Aydın

et al. 2019

Sakarya Medical Journal

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Orcid :Yaşar Keskin https://orcid.org/: 0000-0003-4457-5917 Kevser Gümüşsu https://orcid.org/0000-0002-5231-2757 Teoman Aydın https://orcid.org/0000-0002-0902-6771 Sevde Özer Poşul https://orcid.org/0000-0001-5830-5438 Esra Başar Gürsoy https://orcid.org/Abstract Objective In this study, we aimed to evaluate autonomic nervous system (ANS) functions by using clinical and electrophysiological tests in patients with ankylosing spondylitis (AS), to investigate the relationship with the disease characteristics and to compare the data with healthy individuals. Materials and MethodsForty AS patients and 30 healthy controls were included in this case-control study. Clinical measurements including heart rate at rest, systolic blood pressure response to standing were obtained. The electrophysiological assessments of ANS were performed by sympathetic skin response and R-R interval variation measurements. Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) was used to estimate the disease activity. Patients with AS were also subdivided into two groups; BASDAI≥4 and BASDAI<4. The difference between the groups and correlations between ANS variables and clinical entities were determined.Results Patients expressed feeling of faintness in orthostatic change, abnormal sweating, disturbed bowel function more than control subjects. The patient's heart rate values at rest were higher than control subjects which indicate parasympathetic dysfunction (p=0,001). No significant difference was found on sympathetic skin response (SSR) latencies and amplitudes between patients and control group or patients with low and high disease activity (p>0,05). A correlation was found between SSR latencies and C-Reactif Protein (CRP) levels and disease durations.Conclusion The symptoms of ANS dysfunction were observed more frequently in AS patients than controls but no significant difference of autonomic functions as assessed by R-R interval variation and SSR was found. ÖzAmaç Bu çalışmada, ankilozan spondilitli (AS) hastalarda klinik ve elektrofizyolojik testler kullanarak otonom sinir sistemi (OSS) fonksiyonlarını değerlendirmeyi, hastalık özellikleriyle ilişkiyi araştırmayı ve verileri sağlıklı bireylerle karşılaştırmayı amaçladık. Gereç ve YöntemlerBu vaka-kontrol türü çalışmaya, kırk AS hastası ve otuz sağlıklı kontrol grubu dahil edildi. İstirahatte kalp atışı, ayakta durarak sistolik kan basıncı gibi klinik ölçümler alındı. OSS'nin elektrofizyolojik değerlendirmeleri sempatik cilt yanıtı ve R-R aralık varyasyon ölçümleri ile yapıldı. Hastalık aktivitesini tahmin etmek için Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) kullanıldı. AS'li hastalar da iki gruba ayrıldı; BASDAI≥4 ve BASDAI <4. Gruplar arasındaki fark ve OSS değişkenleri ile klinik özellikler arasında korelasyon belirlendi. Bulgular Hastalar ortostatik değişimde solgunluk hissi, anormal terleme, bozulmuş bağırsak fonksiyonlarını kontrol grubundan daha fazla olduğunu ifade etmişlerdir. Hastaların istirahatte kalp atış hızı değerleri parasempatik disfonksiyonu göst...

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Section: Introductionmentioning

confidence: 99%