Tumor necrosis factor alpha gene polymorphism in Serbian patients with sarcoidosis

Radjenovic-Petkovic, Tatjana; Pejčić, Tatjana; Videnović-Ivanov, Jelica; Jevtović-Stoimenov, Tatjana; Jankovic, I; Nastasijevic-Borovac, Desa; Radojkovic, Danijela

doi:10.2298/sarh1304169r

Cited by 6 publications

(5 citation statements)

References 19 publications

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“…Based on the search strategy, our primary search produced 32 potentially relevant articles, of which 13 qualified articles met the inclusion criteria [7-19]. In total, 1584 patients with sarcoidosis and 2636 controls and were examined.…”

Section: Resultsmentioning

confidence: 99%

“…Of these studies, 12 articles examined the association of the TNF-α gene G-307A polymorphism with sarcoidosis [7-17,19]; five articles focused on the TNF-α gene G-238A polymorphism [10,12,14,15,17]; four articles focused on the TNF-α gene C-857T polymorphism [14,15,17,18]; three articles focused on the TNF-α gene T-1031C and C-863A polymorphisms [14,15,17]; three articles focused on the TNF-β gene A252G polymorphism [13,14, 16]. …”

Section: Resultsmentioning

confidence: 99%

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Association of Six Well-Characterized Polymorphisms in TNF-α and TNF-β Genes with Sarcoidosis: A Meta-Analysis

Feng

Zhou

et al. 2013

PLoS ONE

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BackgroundsIn this study, we aimed to investigate the association of six well-characterized polymorphisms in tumor necrosis factor alpha and beta (TNF-α and TNF-β) genes with the risk for sarcoidosis via a comprehensive meta-analysis.Methods And FindingsThe electronic MEDLINE (Ovid) and PubMed databases covering the period from the earliest possible year to June 2013 were searched. Total 13 qualified articles including 1584 patients with sarcoidosis and 2636 controls were recruited. The data were analyzed by RevMan software, and risk estimates were expressed as odds ratios (ORs) and 95% confidence intervals (95% CIs). Analyses of the full data set failed to identify any significant association of TNF-α gene -307A (OR=1.25; 95% CI: 0.98-1.59), -1031C (OR=0.88; 95% CI: 0.71-1.1), -863A (OR=0.89; 95% CI: 0.72-1.11), -238A (OR=0.97; 95% CI: 0.71-1.32), and -857T (OR=1.14; 95% CI: 0.74-1.77) alleles, but a significant association for TNF-β 252A allele (OR=1.65; 95%CI = 1.33-2.04; P<0.00001). Under a random-effects allelic model, there was marginally significant increased risk of sarcoidosis for -307A allele among Caucasians (OR=1.25; 95% CI: 0.96-1.62; P=0.09) but not among Asians (OR=2.12; 95% CI: 0.31-14.27; P=0.44). There was a low probability of publication bias as reflected by the fail-safe number.ConclusionsThis meta-analysis extended previous findings on the association between the TNF-α and TNF-β genetic polymorphisms and sarcoidosis, by showing that the TNF-β gene A252G polymorphism might be a potential risk factor for the development of sarcoidosis.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Association of Six Well-Characterized Polymorphisms in TNF-α and TNF-β Genes with Sarcoidosis: A Meta-Analysis

Feng

Zhou

et al. 2013

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Based on the search strategy, our primary search produced 32 potentially relevant articles, of which 13 qualified articles met the inclusion criteria [7][8][9][10][11][12][13][14][15][16][17][18][19]. In total, 1584 patients with sarcoidosis and 2636 controls and were examined.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The baseline characteristics of qualified studies are presented in Table 1. Of the 12 case-controls articles examining the association between the TNF-α gene G-307A polymorphism and sarcoidosis risk, 9 involved Caucasian populations [7,9,[11][12][13][15][16][17]19], and 3 included Asian populations [8,10,14].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Of these studies, 12 articles examined the association of the TNF-α gene G-307A polymorphism with sarcoidosis [7][8][9][10][11][12][13][14][15][16][17]19]; five articles focused on the TNF-α gene G-238A polymorphism [10,12,14,15,17]; four articles focused on the TNF-α gene C-857T polymorphism [14,15,17,18]; three articles focused on the TNF-α gene T-1031C and C-863A polymorphisms…”

Section: Study Characteristicsmentioning

confidence: 99%

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Correction: Association of Six Well-Characterized Polymorphisms in TNF-α and TNF-β Genes with Sarcoidosis: A Meta-Analysis

Feng¹,

Zhou²,

Gu³

et al. 2013

PLoS ONE

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Backgrounds:In this study, we aimed to investigate the association of six well-characterized polymorphisms in tumor necrosis factor alpha and beta (TNF-α and TNF-β) genes with the risk for sarcoidosis via a comprehensive meta-analysis. Methods And Findings:The electronic MEDLINE (Ovid) and PubMed databases covering the period from the earliest possible year to June 2013 were searched. Total 13 qualified articles including 1584 patients with sarcoidosis and 2636 controls were recruited. The data were analyzed by RevMan software, and risk estimates were expressed as odds ratios (ORs) and 95% confidence intervals (95% CIs). Analyses of the full data set failed to identify any significant association of TNF-α gene -307A (OR=1.

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Reactive Erythemas and Panniculitides in Connective Tissue Disease

Mazori

Femia

2022

Interdisciplinary Approaches to Overlap Disorders in Dermatology &Amp; Rheumatology

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Tumor necrosis factor alpha gene polymorphism in Serbian patients with sarcoidosis

Abstract: We have found that the TNF-alpha-308A variant is associated with Löfgren's syndrome in Serbian patients with sarcoidosis.

Cited by 6 publications

References 19 publications

Association of Six Well-Characterized Polymorphisms in TNF-α and TNF-β Genes with Sarcoidosis: A Meta-Analysis

Association of Six Well-Characterized Polymorphisms in TNF-α and TNF-β Genes with Sarcoidosis: A Meta-Analysis

Correction: Association of Six Well-Characterized Polymorphisms in TNF-α and TNF-β Genes with Sarcoidosis: A Meta-Analysis

Reactive Erythemas and Panniculitides in Connective Tissue Disease

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