Tumor necrosis factor alpha promoter polymorphism −308 G/A in Brazilian patients with systemic lupus erythematosus

Angelo, Hildson Dornelas; Silva, Helker Albuquerque da; Asano, Nadja Maria Jorge; Muniz, Maria Tereza Cartaxo; Maia, Maria de Mascena Diniz; Souza, Paulo Roberto Eleutério de

doi:10.1016/j.humimm.2012.07.336

Cited by 12 publications

(7 citation statements)

References 40 publications

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“…Moreover, several studies have found a relationship between the TNF-α rs1800629 allele A and susceptibility to CD (de la Concha et al, 2000;Lio et al, 2005), as well as other inflammatory and autoimmune diseases, such as systemic lupus erythematosus (Angelo et al, 2012) and type 1 diabetes (Garrote et al, 2002). In our study, a higher difference in the frequency of the allele A (high producer) was observed when we compared DQ2-positive CD patients with the healthy controls.…”

Section: Discussionsupporting

confidence: 50%

“…Since the TNF-α gene has been located on chromosome 6, within the major histocompatibility complex (MHC) and between HLA class I and II regions, there has been much speculation concerning a genetic association between TNF-α polymorphisms, TNF production, immunologic response, and susceptibility to disease (Cataldo et al, 2003). Some polymorphisms in the promoter region of the gene for TNF-α have been associated with the development of the disease (Angelo et al, 2012), but the allele -308A is the most reported, inducing, especially in homozygosis, higher levels of TNF-α transcription and facilitating the inflammatory response to gluten (Kroeger et al, 2000). In the present study, allelic distribution of the TNF-α promoter region (-308) polymorphism did not show a significant difference between celiac patients and the control group (P = 0.9244).…”

Section: Discussionmentioning

confidence: 99%

“…For this polymorphism, G/G and G/C genotypes are associated with the production of high levels of IL-6, while the C/C genotype is associated with low levels (Santhosh et al, 2010). However, contradictory results for these interleukin polymorphisms influencing autoimmune inflammatory diseases have been found in different populations (Schotte et al, 2001;Mirowska-Guzel et al, 2011;Angelo et al, 2012;Mosaad et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Tumor necrosis factor-α and interleukin-6 gene polymorphism association with susceptibility to celiac disease in Italian patients

et al. 2015

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ABSTRACT. The aim of this research was to study polymorphisms in the genes encoding cytokines interleukin-6 (IL-6) and tumor necrosis factoralpha (TNF-α) in patients with celiac disease (CD) antigens DQ2 (DQ2-positive) or DQ8 (DQ8-positive). We compared the results with healthy controls to determine whether any of the polymorphisms have a role in susceptibility to CD. 16343-16352 (2015) included in the study. Analysis of single nucleotide polymorphisms (SNPs) was carried out using the polymerase chain reaction-restriction fragment length polymorphism method. Significant differences for the TNF-α (-308 G>A) polymorphism were observed when we compared the flowing groups: DQ2-positive with controls [odds ratio (OR) = 0.45, P = 0.0002]; DQ8-positive with controls (OR = 3.55, P < 0.0001); and DQ2-positive with DQ8-positive (OR = 0.12, P < 0.0001). We did not observe a statistically significant association between IL-6 (-174 G>C) polymorphism and CD (P > 0.05). Our results suggest that TNF-α (-308 G>A) polymorphism may play a role in susceptibility to CD in Italian patients.

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Section: Discussionsupporting

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Tumor necrosis factor-α and interleukin-6 gene polymorphism association with susceptibility to celiac disease in Italian patients

et al. 2015

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“…Recent meta-analysis has shown also that individuals carrying TNF-α − 308 A risk allele were significantly associated with SLE in European, South American and Mexican subjects but was not associated with SLE in Asian and African subjects ( Pan et al, 2012 ). Similar conclusion regarding the association of TNF-α − 308 A allele was also found among Brazilian ( Angelo et al, 2012 ), Colombian ( Guarnizo-Zuccardi et al, 2007 ), Mexican ( Jiménez-Morales et al, 2009 ), North American ( Parks et al, 2004 ), Spanish ( Suárez et al, 2005 ), Asian ( Lin et al, 2009 ) and Caucasian ( van der Linden et al, 2001 ) patients. This might be explained by the fact that TNF-α is a pro-inflammatory cytokine involved in different immune-regulated diseases including autoimmune, infectious, and malignant ones ( Lee et al, 2006 ).…”

Section: Discussionsupporting

confidence: 78%

TNF-α − 308 G > A and IFN-γ + 874 A > T gene polymorphisms in Egyptian patients with lupus erythematosus

et al. 2016

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BackgroundSystemic lupus erythematosus (SLE) is associated with immunogenetic factors. This study was planned to test for the association of TNF-α − 308 and IFN-γ + 874 gene polymorphisms with susceptibility and severity of SLE in Egyptian cases.Subjects and methodsThis is a case controlled study including 125 Egyptian cases with SLE in addition to 112 healthy unrelated individuals from the same locality. For all participants, TNF-α − 308 G > A and IFN-γ + 874 A > T genetic polymorphisms were characterized using the PCR technique.ResultsCases with SLE showed a significantly higher TNF-α − 308 A allele carriage rate (AA + GA genotypes) compared to controls (26.4% vs. 12.5%, p = 0.009, OR = 2.51, 95% CI = 1.26–4.99). These cases showed also a significantly higher carriage rate for the IFN-γ + 874 T allele (AT + TT genotypes) compared to controls (47.2% vs. 32.1%, p = 0.02, OR = 1.89, 95% CI = 1.11–3.21). Comparing age, gender, and disease severity presented by nephritis class, activity and chronicity indices in cases carrying the TNF-α − 308 A allele and in cases carrying IFN-γ + 874 T allele versus others showed no significant difference (p > 0.05).ConclusionsTNF-α − 308 A and IFN-γ + 874 T allele carriage are associated with susceptibility but not severity of SLE in Egyptian subjects.

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“…One hundred and sixty papers were relevant to the searching words, and a total of 38 studies met the inclusion criteria. Finally, there were 39 studies included in this meta‐analysis including our case–control study . Among these recruited investigations, five were published in Chinese and the others were reported in English.…”

Section: Resultsmentioning

confidence: 99%

Association Between TNF‐α Promoter −308 A/G Polymorphism and Systemic Lupus Erythematosus Susceptibility: A Case–Control Study and Meta‐Analysis

Yang

Tang

et al. 2017

Scand J Immunol

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The tumour necrosis factor-α (TNF-α) promoter -308 A/G polymorphism plays an important role in the aetiology of systemic lupus erythematosus (SLE). Several studies have estimated the association between TNF-α -308 A/G and SLE risk. However, results were inconsistent. A case-control study was carried out to explore the association between TNF-α -308 A/G and the SLE risk in a Chinese Han population. Meta-analysis combining present with previous studies was conducted to further explore the association. Our case-control study included 556 patients with SLE along with 570 matched healthy controls. TNF-α -308 A allele was significantly increased in patients with SLE compared with controls (OR = 2.184, 95% CI: 1.718-2.778, P < 0.001). Genotypes AA and AG were associated with the susceptibility to SLE as compared with the GG genotype, as well as the dominant model (AA+AG versus GG), respectively. The meta-analysis included 41 comparative studies involving 4799 patients and 6635 controls. An association between SLE and allele A was found in the overall populations (OR = 1.70, 95% CI: 1.46-1.98, P < 0.001). In addition, we discussed the correlation between this polymorphism and lupus nephritis (LN) risk, showing that allele A was significantly related to LN in the overall populations (OR = 1.80, 95% CI: 1.21-2.68, P = 0.004). The results from our case-control study and the meta-analysis indicate that the TNF-α -308 A allele is significantly associated with an increased risk of SLE/LN.

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Tumor necrosis factor alpha promoter polymorphism −308 G/A in Brazilian patients with systemic lupus erythematosus

Cited by 12 publications

References 40 publications

Tumor necrosis factor-α and interleukin-6 gene polymorphism association with susceptibility to celiac disease in Italian patients

Tumor necrosis factor-α and interleukin-6 gene polymorphism association with susceptibility to celiac disease in Italian patients

TNF-α − 308 G > A and IFN-γ + 874 A > T gene polymorphisms in Egyptian patients with lupus erythematosus

Association Between TNF‐α Promoter −308 A/G Polymorphism and Systemic Lupus Erythematosus Susceptibility: A Case–Control Study and Meta‐Analysis

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