Tumor Necrosis Factor and Interleukin‐6 Gene Polymorphisms and Endometriosis Risk in Asians: A Systematic Review and Meta‐Analysis

Li, Jie; Chen, Yang; Wei, Shixiu; Wu, Hongbo; Liu, Chengjun; Huang, Qiufeng; Li, Liuming; Hu, Yanling

doi:10.1111/ahg.12048

Cited by 16 publications

(14 citation statements)

References 43 publications

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“…Increases in cytokine levels in body fluids, such as peritoneal fluid and presence of cytokine expressions in endometrial cells, give rise to the thought that there is an interaction between these cases and they can be related to pathogenesis and the spread of the disease. Earlier studies have shown the existence of TNF-α and IL-6 in body fluids of patients with endometriosis 5,17,21,22 . In our study, this is the first time that both TNF-α and IL-6 expressions have been shown immunohistochemically in both normal and ectopic endometrial tissue.…”

Section: Discussionmentioning

confidence: 96%

“…It is widely accepted that the pathogenesis of the disease is related to the accumulation of cytokines and various growth factors secreted from macrophages and leukocytes in the peritoneal fluid 8,18 . Undeniably, it is found that, many cytokines and growth factors, such as TNF-α 5,21,22 , IL-1 23 , IL-6 17 , IL-8 24,25 , IL-10 26 , VEGF 16 , MCP-1 25 and MCP-2 increased significantly in peritoneal fluid of women with endometriosis compared to healthy women. It is thought that the presence of a high percentage of peritoneal fluid may have a role in triggering the development of endometriosis; however, the presence of various cytokines and increased levels of these cytokines in body fluids have been shown in several recent studies 5,17,23,25 .…”

Section: Discussionmentioning

confidence: 99%

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Expression of interleukin 6 and tumor necrosis factor alpha in endometriotic tissues: an immunohistochemical study

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Çetin

et al. 2020

Cukurova Medical Journal

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Öz Purpose: The aim of this study is to investigate Tumor necrosis factor alpha (TNF-α) and Interleukin 6 (IL-6) expressions in normal and endometriotic human tissue using immunohistochemical methods. Materials and Methods: This study examined tissue sections obtained from the tissue biopsies of ectopic endometrium taken from 24 women between the ages of 20 to 40 years. Additionally, the tissue sections taken from the normal endometrium obtained from 10 patients without any endometrial dysfunction due to dilation or curettage were also evaluated, as the control group. Tissue sections prepared by light microscopic and immunohistochemical methods were examined under a light microscope. Results: In the control group TNF-α and IL-6 expressions were identified at varying levels, from weak to moderate, in surface and glandular epithelium; however, there was no evidence of a significant staining in the stromal cells. It is found that TNF-α and IL-6 immunoreactivity in the endometriotic tissues were significantly increased in the epithelial cells, stromal cells and macrophages compared to the control endometrium. Expressions of TNF-α and IL-6 were both strong in the ectopic endometrial tissues. Conclusion: We conclude that TNF-α and IL-6 are important cytokines involved in the pathogenesis of the endometriosis. Amaç: Bu çalışmada, insanda normal endometriyum ve endometriyotik dokularda Tümör nekroz faktör-α (TNFα) ve Interlökin-6 (IL-6) ekspresyonlarının immünohistokimyasal yöntemler ile araştırılması amaçlandı. Gereç ve Yöntem: Çalışmada incelenen doku kesitleri, 20-40 yaşları arasındaki 24 kadından alınan ektopik endometriyum doku biyopsilerinden elde edildi. Ayrıca herhangi bir endometriyal fonksiyon bozukluğu bulunmayan, ancak diletasyon veya küretaj nedeniyle, 10 hastadan elde edilen endometriyum dokularından alınan kesitler de kontrol grubu olarak değerlendirildi. Işık mikroskobik ve immünohistokimyasal yöntemler ile hazırlanan doku kesitleri, ışık mikroskopta incelendi. Bulgular: TNF-α ve IL-6 ekspresyonunun kontrol grubunda yüzey ve bez epitelinde zayıftan orta dereceye kadar değişen düzeylerde olduğu gözlendi. Buna karşın stromal hücrelerde belirgin bir boyanmaya rastlanmadı. TNF-α ve IL-6'nın endometriyotik dokulardaki immünreaktivitesinin kontrol endometriyum ile karşılaştırıldığında, epitel hücreleri ile stromal hücreler ve makrofajlarda belirgin olarak artış gösterdiği bulundu. TNF-α ve IL-6 ekspresyonlarının her ikisi de ektopik endometriyal dokuda, güçlü olarak eksprese olmuştur. Sonuç: TNF-α ve IL-6'nın endometriyozis oluşumu ve patogenezinde rol alan önemli sitokinler oldukları kanaatine varıldı.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Expression of interleukin 6 and tumor necrosis factor alpha in endometriotic tissues: an immunohistochemical study

Furucu

Sencar

Çetin

et al. 2020

Cukurova Medical Journal

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“…Interleukin-6 IL-6 -174C/G gene polymorphisms may be a risk factor for endometriosis for Asians (125). IL-6 -634C/G and ICAM-1 469K/E polymorphisms synergistically affect the susceptibility for endometriosis in the Japanese population (126).…”

Section: Il-6mentioning

confidence: 99%

“…long cytoplasmic tail, 1 (142). TNF-α -238A/G gene polymorphisms may be a risk factor for endometriosis for Asians (125). TNFA promoter polymorphism was associated with susceptibility to endometriosis (144).…”

Section: Kir3ds1mentioning

confidence: 99%

Understanding the role of epigenomic, genomic and genetic alterations in the development of endometriosis (Review)

Kobayashi

Imanaka

Nakamura

et al. 2014

Molecular Medicine Reports

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Endometriosis is a complex disease influenced by genetic, epigenetic and environmental factors. The aim of the present study was to describe genomic instability, genetic polymorphisms and their haplotype, epigenetic alterations associated with predisposition to endometriosis, and the key factors associated with endometriosis-related ovarian neoplasms. Focus has been given on the developing paradigm that epigenetic alterations or genetic mutations in endometriosis may start in utero or in adolescent and young adults. A search was conducted between 1966 and 2010 through the English language literature (online Medline PubMed database) using the keywords endometriosis combined with epigenetic, genetic and environment. Genetic/epigenetic alterations include single‑nucleotide polymorphisms (SNPs), copy number variation, loss of heterozygosity (LOH), and promoter methylation. Several genes with genetic polymorphisms analyzed in the present study tended to overlap previously reported endometriosis susceptibility genes. Retrograde menstruation leads to iron overload, which facilitates the accumulation of somatic mutations through Fenton reaction-mediated oxidative stress. The epigenetic disruption of gene expression plays an important role in the development of endometriosis through interaction with environmental changes. There seems to be at least three spatiotemporally distinct phases of the development of endometriosis: the initial phase of genetic background inherited from parents; followed by epigenetic modifications in the female offspring; and iron overload, which is subject to dynamic modulation later in life. In conclusion, the marked regulation of endometriosis susceptibility genes may stem from a mechanism responsible for epigenetic and genetic mutations based on the microenvironmental changes.

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“… 4 , 5 Even though several meaningful conclusions have been drawn in previous studies, 6 – 8 the exact etiology of endometriosis remains unclear and standard treatment for endometriosis has been deficient so far. 9 To sum up, considering the unfavorable outcomes of people who are affected by endometriosis and vague etiology of endometriosis-related infertility, it is of great significance to further explore genetic risk factors associated with endometriosis-related infertility.…”

Section: Introductionmentioning

confidence: 99%

Association of FCRL3 Genetic Polymorphisms With Endometriosis-Related Infertility Risk

Zhang

et al. 2015

Medicine

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The Fc receptor-like 3 (FCRL3) gene was reported to be linked to a variety of autoimmune diseases, including endometriosis-related infertility. However, this linkage has not been studied in Chinese population and there has been no meta-analysis on the interrelationship of FCRL3 gene and endometriosis-related infertility. The aim of the study was to investigate the association between FCRL3 genetic polymorphisms and the risk of endometriosis-related infertility in Han Chinese, and a further meta-analysis was conducted to confirm our results.Four single nucleotide polymorphisms (SNPs) (rs7528684 [FCRL3_3], rs11264799 [FCRL3_4], rs945635 [FCRL3_5], and rs3761959 [FCRL3_6]) on FCRL3 gene were genotyped in a case–control cohort composed of 217 patients suffering from endometriosis-related infertility and 220 healthy controls using cleaved amplification polymorphism sequence-tagged sites (polymerase chain reaction–restriction fragment length polymorphism, PCR–RFLP). Odds ratio (OR) and its 95% confidence interval (CI) was used to evaluate the association quantitatively. Furthermore, a meta-analysis of previous studies including the present study was implemented through Stata 11.0 (Stata Corporation, College Station, TX).We found an approximately 1.4-fold significantly increased frequency of the FCRL3_3 variant in women with endometriosis-related infertility over the controls (OR = 1.41 [95% CI = 1.08–1.84], P = 0.013). However, no significant difference was found between women with endometriosis-related infertility and controls for FCRL3_4, FCRL3_5, and FCRL3_6. Regardless of the symptoms and the revised classification of the American Society of Reproductive Medicine (rASRM) stage of endometriosis, there was a significant association between FCRL3_3 variant and an increased risk of endometriosis-related infertility. Meta-analysis of previous studies combined with the present study further confirmed the association between FCRL3_3 and the risk of endometriosis-related infertility.In summary, the present study suggested that FCRL3_3 variant was associated with an increased risk of endometriosis-related infertility, regardless of symptoms, and rASRM stage of the patients. Meta-analysis of previous studies combined with the present study further confirmed our results. Further large-scale studies in the future are warranted to explore the association between FCRL3 genetic polymorphisms and endometriosis-related infertility, as well as other human diseases, in Asian and other ethnicities.

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Tumor Necrosis Factor and Interleukin‐6 Gene Polymorphisms and Endometriosis Risk in Asians: A Systematic Review and Meta‐Analysis

Cited by 16 publications

References 43 publications

Expression of interleukin 6 and tumor necrosis factor alpha in endometriotic tissues: an immunohistochemical study

Expression of interleukin 6 and tumor necrosis factor alpha in endometriotic tissues: an immunohistochemical study

Understanding the role of epigenomic, genomic and genetic alterations in the development of endometriosis (Review)

Association of FCRL3 Genetic Polymorphisms With Endometriosis-Related Infertility Risk

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