Tumor necrosis factor receptor II gene polymorphism and severity of rheumatoid arthritis

Il-4Rα, TNF-α,TNF-α Receptor, and CD4 Enhancer Genes Polymorphisms in Rheumatoid Arthritis Saudi Female Patients

“…As previously reported by van der Helm-van Mil [67], we observed a lack of association between the TNFRII 196R allele and the functional severity of RA, which is in disagreement with the findings reported by Constantin et al, [32]. There may be several explanations for these discrepancies, including the heterogeneity of the studied population, differences in the selected outcome criterion between studies, and the influence of treatment.…”

“…The results of the present study support the hypothesis that there is an association between the TNFRII -196 M/R gene polymorphism and the functional severity of early RA [32].Recently, TNFRII -196R transfectants have been shown to be associated with higher production of IL-6 [16], which plays a crucial role in the pathogenesis of RA. This result support the idea that the genes for susceptibility to systemic lupus erythematosus and RA are partially overlapping [63].The present findings revealed statistical significance between the TNFRII196R allele and RA diagnosis.…”

“…The pleiotropic biological activities of TNF-α are mediated by its binding to TNF receptors (TNFR) Type I and II [31]. Both are expressed in synovial fluid and cartilage in RApatients [32]. Several studies, upon the gene polymorphism at 169 M/R in TNFR type II showed that, this polymorphism has been implicated in severity in RA [33].This work was done to evaluate the association of IL-4Rα, TNF-α, and CD4 enhancer genes polymorphism in development and severity of RA in female Saudi patients.…”

The tumour necrosis factor receptor superfamily member 1b 676T>G polymorphism in relation to response to infliximab and adalimumab treatment and disease severity in rheumatoid arthritis

“…This polymorphism causes a non-conservative amino acid substitution (methionine (M) to arginine (R)) at codon 196 (M196R) within the fourth cysteine-rich domain of the extracellular domain and might affect the binding site for TNFα-converting enzyme 9. This suggests a disturbed processing of membrane-bound TNF-RII by this enzyme and might affect the levels and function of TNFR 5 8 9. sTNFR levels can be important in the response to anti-TNF treatment as the receptor acts as an endogenous TNF antagonist 4.…”

Circulating Levels of TNF Receptor II Are Prognostic for Patients with Peripheral T-cell Non–Hodgkin Lymphoma

“…It was shown that single-nucleotide polymorphisms (SNP) or elevated plasma levels are associated to some degree with the risk and clinical outcome of some subtypes of lymphomas, solid tumors, and autoimmune diseases such as rheumatoid arthritis or allergy/asthma (16)(17)(18)(19)(20)(21)(22)(23).…”