Tumor necrosis factor SNP haplotypes are associated with iron deficiency anemia in West African children

Common Variants and Haplotypes in the TF, TNF-α, and TMPRSS6 Genes Are Associated with Iron Status in a Female Black South African Population

“…This allele combination has previously been associated with an increased risk of ID in a cohort of West African children (47). The SNPs in the identified combination are present in the TNF-a (rs1799964 and rs1800629) and NFKBIL1 (rs2071592) genes, which are both involved in inflammatory processes.…”

HLA and Infectious Diseases

“…Given the complexity of the disease, larger samples and more detailed investigation of clinical phenotypes may reveal more subtle effects. For example, TNF haplotypes have recently been shown to be associated with iron deficiency anemia in West Africa (16). TNF is thought to inhibit intestinal iron absorption and macrophage iron release.…”

Asymptomatic malaria in the etiology of iron deficiency anemia: a nutritionist's viewpoint

“…However, cross-sectional associations between hepcidin and iron absorption were only apparent in the noninfected state, showing that there is still much to learn about the role of hepcidin in modulating iron absorption in different diseases. In the meantime it is worth noting that such a life-critical process as regulation of duodenal iron absorption is likely to have a series of back-up mechanisms, and it is known that tumor necrosis factor-a can block iron absorption through a hepcidin-independent mechanism (10) and that this is also a contributor to malaria-associated iron deficiency anemia (11).…”