Tumor Necrosis Factor‐α in the Placenta is not Elevated in Pre‐eclamptic Patients Despite its Elevation in Peripheral Blood

Hayashi, Masatoshi; Ueda, Yoshihiko; Yamaguchi, Takehiko; Sohma, Ryoichi; Shibazaki, Mitsuei; Ohkura, Takeyoshi; Inaba, Noriyuki

doi:10.1111/j.1600-0897.2005.00253.x

Cited by 48 publications

(28 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Inflammation is a part of the pathogenesis and is considered as one of the adverse pregnancy outcomes (51)(52)(53)(54). CRP, IL-6 and TNF-α are increased with preeclampsia, (55)(56)(57)(58), intrauterine growth restriction (IUGR) (51,52,59), and preterm labor/birth (60)(61)(62)(63) (55)(56)(57)(58). At the present study, subjective sleep quality is in significant correlation with abortion (P = 0.000).…”

Section: Discussionmentioning

confidence: 52%

The Relationship Between Sleep Disorders During Pregnancy and

Alihosseini

Najar

Haghighizadeh

2017

Jundishapur J Chronic Dis Care

View full text Add to dashboard Cite

Background: Sleep disorder is one of the most common complaints of pregnancy that can lead to maternal and fetal complications. Objectives: The main purpose of this study is to investigate the correlation between sleep disorders of pregnancy and abortion. Methods: This study is conducted using a case-control method on 218 women in the age range of 18 -35 years old with singletonpregnancy passing their first or second pregnancy in Ahvaz, Iran. Continuous sampling was conducted on the basis of characteristics of the research unit. The case group (n = 109) included women hospitalized because of an abortion, and the control group (n = 109) consists of pregnant women above 22 weeks, who were referred to healthcare centers to get pregnancy cares. The data collection was done using a demographic questionnaire and pittsburgh sleep quality index (PSQI). Data analysis was performed using SPSS-22 and t-test for quantitative variables and Chi-Square for qualitative variables. Results: Obtained results from the study showed that there is a significant relationship between abortion and sleep duration (P = 0.000), subjective sleep quality (P = 0.000), sleep latency (P = 0.000), habitual sleep efficiency (P = 0.000), sleep disturbances (P = 0.000), daytime dysfunction (P = 0.000), and total valued of sleep disorder (P = 0.000). However, the correlation was insignificant in case of use of sleeping medication (P = 0.233). Conclusions: According to the obtained results, there is a significant correlation between sleep disorder and abortion. Therefore, training sleep health and suitable consultations during pregnancy would be effective in field of preventing abortion and with the aim of achieving to safe pregnancy.

show abstract

Section: Discussionmentioning

confidence: 52%

The Relationship Between Sleep Disorders During Pregnancy and

Alihosseini

Najar

Haghighizadeh

2017

Jundishapur J Chronic Dis Care

View full text Add to dashboard Cite

show abstract

“…6, 7 Most studies of TNFα in preeclampsia report higher circulating concentrations in affected pregnancies compared with uncomplicated control pregnancies, 3, 7 however TNFα was not greater in placental tissues from preeclamptic pregnancies compared to placentas from uncomplicated pregnancies. 8,9 Taken together, these findings may indicate that as in the metabolic syndrome, 10-12 TNFα is produced in excess by adipocytes in preeclamptic women. Mounting evidence associates metabolic syndrome and preeclampsia.…”

Section: Introductionmentioning

confidence: 72%

“…3,9,20,22 In previous studies, BMI was adjusted for statistically, matched, or not considered in studies of TNFα during pregnancy. Our study analyzed TNFα in preeclampsia and uncomplicated pregnancies specifically by lean and obese BMI categories.…”

Section: Commentmentioning

confidence: 99%

A Comparison of Circulating TNF-α in Obese and Lean Women with and without Preeclampsia

Founds

Powers

Patrick

et al. 2008

Hypertension in Pregnancy

View full text Add to dashboard Cite

Objectives: We hypothesized that TNFα would be higher in obese versus lean preeclamptic subjects. Methods:Total plasma TNFα was measured in a nested case-control study of 123 nulliparous lean and obese control and preeclamptic subjects.Results: Adjusted mean TNFα concentrations were 0.97±0.11 (pg/ml ± SEM) in lean controls, 1.01 ±0.10 in obese controls, 1.43±0.11 in lean preeclamptics and 1.16±0.11 in obese preeclamptics. Pregnancy outcome was the single predictor of TNFα concentration in the general linear regression model (p=0.04). Conclusion:TNFα concentration was higher in preeclamptic compared to control subjects. Obesity was not associated with higher TNFα concentrations in preeclamptic or control subjects.

show abstract

“…However, the intermediary mechanisms linking placental ischemia and the increased BP in PE are unclear. Recent studies in a pregnant rat model of RUPP, produced by occlusion of the lower abdominal aorta and the main uterine branches of the ovarian arteries, have suggested significant changes in renal functions as a possible cause of the increased BP (Alexander, 2001a; Sibai, 2005bHibbard, 2005Hibbard, 2005Silver, 1998Hibbard, 2005Moran, 2003Greenwood, 2001Sibai, 2005bKazerooni, 2003Xiang, 2005Khatun, 2000Brosnihan, 2004Brosnihan, 2004Minegishi, 1999Resnik, 2005Shaarawy, 2005Elsheikh, 2001Hayashi, 2005 AngII, angiotensin II; Ang-(1-7), angiotensin (1-7); ANP, atrial natriuretic peptide; BNP, brain natriuretic peptide; BP, blood pressure; NPY, neuropeptide-Y; TNF-α, tumor necrosis factor-α; VEGF, vascular endothelial growth factor. .…”

Section: Uteroplacental Circulation During Normal Pregnancy and Pementioning

confidence: 99%

Neurovascular Mechanisms of Hypertension in Pregnancy

Stennett

Khalil²

2006

CNR

View full text Add to dashboard Cite

Normal pregnancy is associated with significant changes in the neuronal and vascular control mechanisms of blood pressure (BP). Preeclampsia (PE) is a major complication of pregnancy characterized by proteinuria, and increased vascular resistance and BP. If untreated, PE leads to eclampsia with serious seizures and severe hypertension. However, the neurovascular mechanisms of hypertension in pregnancy and PE are unclear. Studies in animal models of hypertension in pregnancy suggest that inadequate cytotrophoblast invasion of uterine spiral arteries causes reduction in uteroplacental perfusion pressure leading to placental ischemia/hypoxia. Placental ischemia may promote the release of biologically active factors such as cytokines and reactive oxygen species. These circulating factors may increase the vascular permeability, cross the blood-brain barrier, and affect the sympathetic tone and the neuronal control mechanisms of BP. Placental factors could also cause endothelial cell dysfunction and inhibit nitric oxide (NO)-cyclic guanosine monophosphate (cGMP), prostacyclin (PGI(2))-cyclic adenosine monophosphate (cAMP), and hyperpolarizing factor vascular relaxation pathways. Additionally, placental factors may induce endothelium-derived contracting factors such as endothelin, thromboxane and angiotensin II, which stimulate Ca(2+)-dependent vascular smooth muscle (VSM) contraction or increase protein kinase C activity and enhance myofilament sensitivity to intracellular free calcium concentration ([Ca(2+)](i)). The increased sympathetic tone combined with systemic decrease in endothelium-dependent vascular relaxation and enhanced VSM contraction may contribute to the increased vascular resistance and BP associated with PE. The hypertensive state in severe PE may weaken the blood-brain barrier and precipitate convulsions and cerebral hemorrhage. Careful monitoring of maternal neuronal, endothelial, and VSM function during pregnancy should circumvent the life-threatening neurovascular complications of PE-eclampsia.

show abstract

Tumor Necrosis Factor‐α in the Placenta is not Elevated in Pre‐eclamptic Patients Despite its Elevation in Peripheral Blood

Cited by 48 publications

References 26 publications

The Relationship Between Sleep Disorders During Pregnancy and

The Relationship Between Sleep Disorders During Pregnancy and

A Comparison of Circulating TNF-α in Obese and Lean Women with and without Preeclampsia

Neurovascular Mechanisms of Hypertension in Pregnancy

Contact Info

Product

Resources

About