Tumor Necrosis Factor‐α, Interleukin‐6, and Interleukin‐8 Secretion and the Acute‐Phase Response in Patients with Bacterial and Tuberculous Osteomyelitis

Evans, Carlton A.; Jellis, John E.; Hughes, Sean; Remick, Daniel G.; Friedland, Jon S.

doi:10.1086/515313

Cited by 52 publications

(49 citation statements)

References 46 publications

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“…Systemic inflammation in response to infectious and inflammatory conditions is the common cause of thrombocytosis. IL6 release has been shown to produce an acute inflammatory cascade in pulmonary TB causing megakaryocytopoiesis [15,16].…”

Section: Discussionmentioning

confidence: 99%

Comparison of platelet count in tuberculosis spine to other spine pathology

Daniel

Dunn

2013

Eur Spine J

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Purpose Haematological markers currently used to investigate TB spine vary from WCC, Anaemia, ESR and CRP. Platelet count in TB spine as a marker has been inadequately investigated. Method In this retrospective review, Platelet count in TB spondylitis on admission was compared to patients undergoing other elective spinal surgery (control) preoperatively. Comparisons of the platelets with ESR and the effect of HIV on platelet count in TB spine were also evaluated. Results 160 TB spine patients showed statistically significant higher platelet count when compared to 210 patients in the control group (p \ 0.001). 52.5 % patients had a raised platelet count in the TB spondylitis group. Raised Platelet count had a sensitivity and specificity of 52.5 % and 86.2 %, respectively in TB spondylitis. ESR and platelet count had a Pearson correlation r = 0.31 (p \ 0.001). HIV however did not statistically show any difference in the platelet count (p = 0.12). Conclusion A raised platelet count in spinal pathology may be used as an inflammatory marker of TB spondylitis.

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Section: Discussionmentioning

confidence: 99%

Comparison of platelet count in tuberculosis spine to other spine pathology

Daniel

Dunn

2013

Eur Spine J

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“…29 It was de tec ted that over pro duc ti on of IL-6 was obser ved in so me au to im mu ne di se a ses and chro nic inf lam ma tory re ac ti ons. 30 A col la gen li ke pro te in na med adi po nec tin which is sec re ted from adi po se tis su e is emp ha sized to be an im por tant an ti-at he ro ge nic, an ti di abe tic and an ti-inf lam ma tory pro te in in re cent stu di es. 31 When the en dot he li al bar ri er is da ma ged, be ing sus cep tib le to mec ha ni cal stress and che mical com po unds such as oxi di zed LDL, adi po nec tin bin ds su ben dot he li al col la gen ac cu mu la ted in the su ben dot he li al spa ce of vas cu lar walls whe re it mani fests its an ti-at he ro ge nic pro per ti es.…”

Section: Discussionmentioning

confidence: 99%

Serum Interleukin-6 and Adiponectin Levels in Patients with Active or Inactive Behçet’s Disease

Etem¹,

Yildirmak²,

Önalan³

et al. 2010

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : Beh çet's di se a se (BD) is a chro nic syste mic inf lam ma tory di se a se and its etio pat ho ge ne sis still re ma ins unk nown. Cyto ki nes play a ro le in im mu ne res pon se and inf lam ma tory re ac ti ons. The aim of this study is to de ter mi ne the le vels of pro inf lam ma tory cyto ki ne in ter le ukin-6 (IL-6) and an ti-inf lam ma tory cyto ki ne adi po nec tin in the sera of pa ti ents with BD and to assess their im por tan ce as bi o lo gi cal mar kers for di se a se ac ti vity. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : Forty-four BD pa ti ents [19 ma les, 25 fe ma les, age: 35.65 ± 10.84 yrs (me an ± stan dart de vi a ti on) (SD)] and 25 he althy con trols (10 ma les, 15 fe ma les, age: 29.80 ± 8.20 yrs) we re inc lu ded in the study. Pa ti ents we re divided into ac ti ve or inac ti ve gro ups ac cor ding to the ir cli ni cal and la bo ra tory fin dings (acti ve, n= 21; inac ti ve, n= 23). We de ter mi ned se rum IL-6 le vels using the che mi lu mi nes cen ce method, and se rum adi po nec tin le vels by ELI SA met hod. Re sults we re ex pres sed as me an ± stan dard er ror (SE). R Re e s su ul lt ts s: : Se rum le vels of IL-6 and adi po nec tin in BD pa ti ents (n= 44) (5.24 ± 0.84 pg/mL; 22.31 ± 1.71 µg/mL, res pec ti vely) we re si mi lar to the con trol gro up (n= 25) (4.59 ± 1.01 pg/mL; 21.68 ± 1.91 µg/mL, res pec ti vely). No sig ni fi cant dif fe ren ce was fo und in IL-6 and adi po nec tin le vels bet we en the ac ti ve (n= 21), inac ti ve (n= 23) and con trol (n= 25) gro ups. C Co on nc c l lu u s si i o on n: : In pa ral lel with the pre sen ce of inf lam ma ti on and in cre a sed CRP, eryt hrocy te se di men ta ti on ra te and white blood cell co unt, hig her IL-6 and lo wer adi po nec tin le vels were ex pec ted in ac ti ve BD pa ti ents com pa red to the con trols. However, they were found to be si mi lar in all gro ups. We conc lu de that on go ing an ti-inf lam ma tory tre at ment sho uld be ta ken in to con si de ra ti on whi le in ter pre ting the cyto ki ne levels in the se pa ti ents. K Ke ey y W Wo or rd ds s: : Beh cet's syndro me; adi po ki nes; in ter le u kin-6 Ö ÖZ ZE ET T A Am ma aç ç: : Beh çet has ta lı ğı (BH), kro nik sis te mik inf la ma tu ar bir has ta lık olup eti yo pa to ge ne zi he nüz bi lin me mek te dir. İmmun ce vap ve inf la ma tu var sü reç iliş ki sin de si to kin ler rol oy na mak tadır lar. Bu ça lış ma nın ama cı, BH'lı has ta la rın se rum la rın da pro-inf la ma tu ar bir si to kin olan IL-6 ile an ti-inf la ma tu ar si to kin olan adi po nek ti nin se vi ye le ri ni öl çe rek, bun la rın has ta lı ğın ak ti vi te sin de bi yo lo jik be lir teç ola rak et ki le ri ni be lir le mek tir. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : Ça lış ma ya 44 BH'lı has ta (19 er kek, 25 ka dın, yaş or ta la ma sı 35.65 ± 10 yıl) ve kon trol gru bu ola rak da 25 sağ lık lı ki şi (10 er kek, 15 ka dın, yaş or ta la ma sı 29.80 ± 8.20 yıl) alın mış tır. Has ta lar kli ni...

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“…In a study on tuberculous osteomyelitis (12 patients) of whom 58% were HIV positive the immunological response was assessed in whole blood by using indirect cytokine proliferation assays [6]. Plasma IL6 levels were significantly elevated in TB as compared to controls.…”

Section: Discussionmentioning

confidence: 99%

Spinal tuberculosis in HIV positive and negative patients: immunological response and clinical outcome

Govender

Annamalai

Kumar

et al. 2000

International Orthopaedics

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We measured cytokine secretion patterns in peripheral blood and granulation tissue by flow cytometry in 16 human immunodeficiency virus (HIV) positive and 26 HIV negative patients with spinal tuberculosis. Anti-retroviral therapy was not prescribed. There were no significant differences in the postoperative morbidity and neurological recovery between the two groups.Résumé Nous avons mesuré, par cytométrie en flux, la sécrétion de cytokine dans le sang périphérique et le tissu de granulation chez des patients atteints de tuberculose rachidienne, 16 HIV positifs et 26 HIV négatifs. Il n'y avait pas de différence significative dans la morbidité post-opératoire et la récupération neurologique entre les deux groupes.

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Tumor Necrosis Factor‐α, Interleukin‐6, and Interleukin‐8 Secretion and the Acute‐Phase Response in Patients with Bacterial and Tuberculous Osteomyelitis

Cited by 52 publications

References 46 publications

Comparison of platelet count in tuberculosis spine to other spine pathology

Comparison of platelet count in tuberculosis spine to other spine pathology

Serum Interleukin-6 and Adiponectin Levels in Patients with Active or Inactive Behçet’s Disease

Spinal tuberculosis in HIV positive and negative patients: immunological response and clinical outcome

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