Tumor necrosis factor-α-mediated severity of idiopathic retinal periphlebitis in young adults (Eales’ disease): implication for anti-TNF-α therapy

Saxena, Sandeep; Pant, Aditya B.; Khanna, Vinay K.; Singh, Kamlesh; Shukla, Rohit; Meyer, Carsten H.; Singh, Vijay K.

doi:10.1007/s12177-010-9053-3

Cited by 11 publications

(3 citation statements)

References 20 publications

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“…Higher levels of TNF were observed in association with the increased severity of retinal periphlebitis [21] . High TNF-␣ -expressing genotype of the host can influence the occurrence and severity of outcome of Eales' disease [22] .…”

Section: Introductionmentioning

confidence: 92%

Elevated Tumor Necrosis Factor in Serum Is Associated with Increased Retinal Ischemia in Proliferative Eales’ Disease

Saxena¹,

Khanna

Pant

et al. 2011

Pathobiology

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Objective: Tumor necrosis factor (TNF) was evaluated in the serum of patients with proliferative stage of Eales’ disease to study its relation with the area of retinal capillary non-perfusion (ischemic retina). Methods: Quantification of the levels of TNF was done using sandwich ELISA in 52 cases with proliferative Eales’ disease and in 32 healthy controls. Seven 50° photographs of different fields of the fundus were taken on fluorescein angiography. The area of retinal capillary non-perfusion denoting retinal cell death was assessed in terms of optic disc areas. Results: TNF levels were found to be significantly increased in the proliferative stage of the disease (mean 23.64 ± 3.7 pg/ml) as compared to controls (mean 12.49 ± 2.9 pg/ml; p < 0.001). Higher levels of TNF were found to be associated with an increased area of retinal capillary non-perfusion on fluorescein angiography. TNF levels of 20–31 pg/ml were observed in cases with neovascularization at the disc (n = 33) as compared to 17–21 pg/ml in cases with neovascularization elsewhere (n = 19). Conclusions: An increasedlevel of TNF is associated with an increased area of the ischemic retina. It is hypothesized that retinal cell death signaling in proliferative Eales’ disease is related to an increased TNF level.

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Section: Introductionmentioning

confidence: 92%

Elevated Tumor Necrosis Factor in Serum Is Associated with Increased Retinal Ischemia in Proliferative Eales’ Disease

Saxena¹,

Khanna

Pant

et al. 2011

Pathobiology

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“…IRBP-3 transports retinoids between the retinal pigment epithelium and the photoreceptors, a critical role in the visual process [5][6][7][8]. Thus, after analyzing the significant role of this selected protein, 3D protein model structures of this protein were generated through comparative modeling approaches.…”

Section: Introductionmentioning

confidence: 99%

Protein–ligand interaction studies of retinol-binding protein 3 with herbal molecules using AutoDock for the management of Eales’ disease

Tiwari

Saxena

Pant

et al. 2012

j ocul biol dis inform

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Eales' disease is an idiopathic retinal vasculitis of the eye. The disease is predominantly characterized by recurrent vitreous hemorrhage. Interphotoreceptor retinolbinding protein 3 plays a significant role in the etiopathogenesis of this condition. It transports retinoids between the retinal pigment epithelium and the photoreceptors; hence, this protein is a potential target for docking studies. In silico data reveal that herbal molecules interact with regulatory domains of interphotoreceptor retinol-binding protein 3 (IRBP-3), resulting into significant docking score and also forms H-bond and several hydrophobic interactions between active residues of IRBP-3. These interactions between the active residues may lead to significant conformational change in that particular portion of the protein. This efficacy and suitability of ligand was determined on the basis of binding energy calculations. Ginkgolide showed minimum binding energy calculations among selected 10 other natural ligands. This fact of virtual screening for potential ligand can give new insights toward the therapeutic intonations and alterations toward the advances in treatment for Eales' disease.

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“…This retinal S-antigen protein has already been purified by chromatographically from whole retina [7]. The 48-kDa protein, a soluble protein found in rod outer segments, is purified through its specific binding to photo excited rhodopsin and is involved in the quenching of light-induced guanosine 3′, 5′-monophosphate-phosphodiesterase activity [8].…”

Section: Introductionmentioning

confidence: 99%

Comparative modeling of retinol-binding protein-3 and retinal S-antigen in Eales’ disease and prediction of their binding sites using computational methods

Tiwari

Trivedi

Srivastava

et al. 2010

j ocul biol dis inform

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Retinal S-antigen and interphotoreceptor retinoidbinding protein-3 play a significant role in the etiopathogenesis of Eales' disease. Protein 3D structures are functionally very important and play a significant role in progression of the disease, hence these 3D structures are better target for further drug designing and relative studies. We developed 3D model structure of retinol-binding protein-3 and retinal S-antigen protein of human involved in Eales' disease. Functional site prediction is a very important and related step; hence, in the current course of analysis, we predicted putative functional site residues in the target proteins. Molecular models of these proteins of Eales' disease as documented in this study may provide a valuable aid for designing an inhibitor or better ligand against Eales' disease and could play a significant role in drug design.

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Tumor necrosis factor-α-mediated severity of idiopathic retinal periphlebitis in young adults (Eales’ disease): implication for anti-TNF-α therapy

Abstract: Tumor necrosis factor-alpha

Cited by 11 publications

References 20 publications

Elevated Tumor Necrosis Factor in Serum Is Associated with Increased Retinal Ischemia in Proliferative Eales’ Disease

Elevated Tumor Necrosis Factor in Serum Is Associated with Increased Retinal Ischemia in Proliferative Eales’ Disease

Protein–ligand interaction studies of retinol-binding protein 3 with herbal molecules using AutoDock for the management of Eales’ disease

Comparative modeling of retinol-binding protein-3 and retinal S-antigen in Eales’ disease and prediction of their binding sites using computational methods

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