Tumor Necrosis Factor-α Plays an Initiating Role in Extracorporeal Circulation-induced Acute Lung Injury

Li, Tao; Luo, Nancy; Du, Lei; Zhou, Jing; Zhang, Jie; Gong, Ling; Jiang, Nenggang

doi:10.1007/s00408-012-9449-x

Cited by 17 publications

(11 citation statements)

References 20 publications

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“…Neutrophil recruitment under the conditions of this study was surmised to occur by egress from the capillaries of the airways through the epithelium into the airway lumen and alveoli (Grammes and Soehnlein 2011) based on the histological evidence of neutrophils in pulmonary capillaries, interstitium, epithelial cells, and airspace. Animals exposed to Sacramento PM may have had higher numbers of neutrophils in the lung because they had significantly increased levels of TNF-α, which is involved in acute lung inflammation and the acute phase reaction (Li et al 2013), compared to animals exposed to the vehicle control and Taiyuan PM. CXCL-1, a neutrophil chemoattractant (De Filippo et al 2008), was also significantly elevated following exposure to Sacramento PM compared to the vehicle control.…”

Section: Discussionmentioning

confidence: 99%

Differential pulmonary effects of wintertime California and China particulate matter in healthy young mice

et al. 2017

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Airborne particulate matter (PM) is a global concern because exposure is associated with adverse cardiorespiratory effects. To better understand source-orientated PM toxicity, a comparative study of the biological effects of fine PM (diameter ≤ 2.5 µm, PM2.5) from two geographically different regions of the world known for high PM air pollution, Shanxi Province in China and the Central Valley in California in the United States was conducted on an equal mass basis. PM2.5 was collected in the capital cities of Shanxi Province (Taiyuan) and California (Sacramento) during the winter season. The overarching hypothesis for this study was to test whether the chemical composition of particulate matter on an equal mass basis from two urban areas, one in China and one in California, can lead to significantly different effects of acute toxicity and inflammation in the lungs of healthy young mice. Male, 8-week old BALB/C mice (n=10/group) were given a single 50 µg dose of vehicle, Taiyuan PM or Sacramento PM by oropharyngeal aspiration. Animals were sacrificed 24 hours later to capture peak inflammation following exposure. Bronchoalveolar lavage, ELISA and histopathology were performed to determine biological effects, along with chemical analysis of PM composition. Sacramento PM was found to have a greater proportion of oxidized organic material than Taiyuan PM. Additionally, Sacramento PM was associated with significantly increased neutrophil numbers and elevated CXCL-1 and TNF-α protein levels compared to the Taiyuan PM. The findings suggest, on an equal mass basis, Sacramento PM was associated with a greater inflammatory response compared to that of Taiyuan PM that could be driven by a higher oxidized state of organic carbon and possibly greater copper content.

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Section: Discussionmentioning

confidence: 99%

Differential pulmonary effects of wintertime California and China particulate matter in healthy young mice

et al. 2017

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“…In animal models of ALI or ARDS induced by endotoxin, mechanical ventilation, or extracorporeal circulation, TNFα has been implicated in disease pathogenesis (Kao et al, 2006; Li et al, 2013; Matuschak and Lechner, 2010). As observed in patients with ALI, TNFα accumulates rapidly in large quantities in the lung after injury in animals, and is considered an initiating cytokine in early disease pathology (Li et al, 2013).…”

Section: Role Of Tnfα In Pulmonary Diseasesmentioning

confidence: 99%

“…As observed in patients with ALI, TNFα accumulates rapidly in large quantities in the lung after injury in animals, and is considered an initiating cytokine in early disease pathology (Li et al, 2013). Pretreatment of rats with etanercept protected against hyperoxia-induced ALI, which is characterized by increases in TNFα and TNFRI, and disruption of alveolar-epithelial barrier functions (Guthmann et al, 2009).…”

Section: Role Of Tnfα In Pulmonary Diseasesmentioning

confidence: 99%

Anti-TNFα therapy in inflammatory lung diseases

Malaviya

Laskin

2017

Pharmacology & Therapeutics

190

137

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Increased levels of tumor necrosis factor (TNF) α have been linked to a number of pulmonary inflammatory diseases including asthma, chronic obstructive pulmonary disease (COPD), acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), sarcoidosis, and interstitial pulmonary fibrosis (IPF). TNFα plays multiple roles in disease pathology by inducing an accumulation of inflammatory cells, stimulating the generation of inflammatory mediators, and causing oxidative and nitrosative stress, airway hyperresponsiveness and tissue remodeling. TNF-targeting biologics, therefore, present a potentially highly efficacious treatment option. This review summarizes current knowledge on the role of TNFα in pulmonary disease pathologies, with a focus on the therapeutic potential of TNFα-targeting agents in treating inflammatory lung diseases.

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“…In particular, activated alveolar macrophages and neutrophils cause the excessive production of pro‐inflammatory cytokines, including tumour necrosis factor‐ α (TNF‐ α ) and interleukin‐1 β (IL‐1 β ), which attract neutrophils and cause the release of further cytokines and chemokines . High levels of TNF‐ α and nitric oxide (NO) production can aggravate lung injuries in patients with acute respiratory distress syndrome and endotoxaemic animals . Hence, these pro‐inflammatory mediators and the upstream nuclear factor‐ κ B (NF‐ κ B) signalling pathway may play critical roles in the pathogenesis of ALI.…”

Section: Introductionmentioning

confidence: 99%

Wogonin prevents lipopolysaccharide‐induced acute lung injury and inflammation in mice via peroxisome proliferator‐activated receptor gamma‐mediated attenuation of the nuclear factor‐kappaB pathway

et al. 2014

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SummaryAcute lung injury (ALI) from a variety of clinical disorders, characterized by diffuse inflammation, is a cause of acute respiratory failure that develops in patients of all ages. Previous studies reported that wogonin, a flavonoid-like chemical compound which was found in Scutellaria baicalensis, has anti-inflammatory effects in several inflammation models, but not in ALI. Here, the in vivo protective effect of wogonin in the amelioration of lipopolysaccharide (LPS) -induced lung injury and inflammation was assessed. In addition, the in vitro effects and mechanisms of wogonin were studied in the mouse macrophage cell lines Ana-1 and RAW264.7. In vivo results indicated that wogonin attenuated LPS-induced histological alterations. Peripheral blood leucocytes decreased in the LPSinduced group, which was ameliorated by wogonin. In addition, wogonin inhibited the production of several inflammatory cytokines, including tumour necrosis factor-a, interleukin-1b (IL-1b) and IL-6, in the bronchoalveolar lavage fluid and lung tissues after LPS challenge, while the peroxisome proliferator-activated receptor c (PPARc) inhibitor GW9662 reversed these effects. In vitro results indicated that wogonin significantly decreased the secretion of IL-6, IL-1b and tumour necrosis factor-a in Ana-1 and RAW264.7 cells, which was suppressed by transfection of PPARc small interfering RNA and GW9662 treatment. Moreover, wogonin activated PPARc, induced PPARc-mediated attenuation of the nuclear translocation and the DNA-binding activity of nuclear factor-jB in vivo and in vitro. In conclusion, all of these results showed that wogonin may serve as a promising agent for the attenuation of ALI-associated inflammation and pathology by regulating the PPARc-involved nuclear factorjB pathway.

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Tumor Necrosis Factor-α Plays an Initiating Role in Extracorporeal Circulation-induced Acute Lung Injury

Abstract: We concluded that TNF-α played an important role in the pathogenesis of ALI and acted as an initiating cytokine at the early stage of ECC-induced ALI.

Cited by 17 publications

References 20 publications

Differential pulmonary effects of wintertime California and China particulate matter in healthy young mice

Differential pulmonary effects of wintertime California and China particulate matter in healthy young mice

Anti-TNFα therapy in inflammatory lung diseases

Wogonin prevents lipopolysaccharide‐induced acute lung injury and inflammation in mice via peroxisome proliferator‐activated receptor gamma‐mediated attenuation of the nuclear factor‐kappaB pathway

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