Tumor neuroendocrino bien diferenciado ileal y adenocarcinoma de colon sincrónicos: a propósito de un caso y revisión de la literatura

Almajano, Enrique Alfaro; Martínez, Lourdes Bengochea; Barrionuevo, Francisco Javier Mateos; Martinez, Carmen Almajano

doi:10.1016/j.patol.2016.08.001

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…From the rare cases with atypical location and patients with more than one SPM (S3 Table), we also found cases with malignant tumors and benign tumors [59,86]. Furthermore, we also found cases with other conditions such as microsatellite instability [50,63], intestinal inflammatory disease [42,50,80] and neurofibromatosis [53,60].…”

Section: Resultsmentioning

confidence: 70%

Neuroendocrine neoplasms of gastrointestinal tract and secondary primary synchronous tumors: A systematic review of case reports. Casualty or causality?

et al. 2019

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Background Neuroendocrine neoplasms (NENs) can arise in most of the epithelial organs of the body and are not a rare condition in the gastrointestinal tract (GIT). The presence of NENs in GIT associated with other secondary primary malignancies (SPM) has been considered an exotic event. This study aims to describe the case reports of NENs accompanied by synchronous primary tumors. Methods and findings We performed a systematic literature search of the databases Scopus, PubMed, Scielo and LILACS to identify case reports that described the presence of NENs in GIT with SPM. 78 case reports were included. The mean of age of the cases was 60.2 years. 60% were male. 95.4% were NENs G1. 17 cases of NENs had metastasis. 80% of SPM were recognized in the GIT (36% in stomach, 27% in large intestine, 11.2% in small intestine, and 5.6% in esophagus). The most common type of SPM was adenocarcinoma (49.4%), followed by GIST (13.5%), other NENs in different GIT segment (7.9%), lymphoma (6.8%), and squamous cell carcinoma (4.5%). The most common tumor in GIT was adenocarcinoma (97.6%) and the presence of adenocarcinoma in the same segment of GIT was found in 68.4% of the cases. Association between adenocarcinomas and NENs in GIT (p:<0.0001) and adenocarcinoma and tumor in the same segment of GIT location were observed (p<0.001). Conclusion These results demonstrate that NENs with SPM are not a rare condition. Several theories have been proposed to explain this association; one of these is the ability of NENs to generate synchronous tumors by autocrine and paracrine effect. We observed an association between adenocarcinomas and NENs in the same segment of GIT.

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Section: Resultsmentioning

confidence: 70%

Neuroendocrine neoplasms of gastrointestinal tract and secondary primary synchronous tumors: A systematic review of case reports. Casualty or causality?

et al. 2019

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“…To date, the literature in English reveals, 20 case reports (18 synchronous cases [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24], 2 metachronous cases [25,26]), 2 case series [25,27], 3 review articles [28][29][30], and about 10 retrospective studies [31][32][33][34] or population-based studies from a National Registry [35][36][37][38][39][40][41] of synchronous or metachronous NET with a second primary malignancy (SPM). A total of 31 patients in 24 articles were included in the study: 28 patients with a synchronous gastrointestinal NET and colorectal adenocarcinoma (Table 1) and 3 patients (including the present study) of 3 articles with metachronous gastrointestinal NET and colorectal adenocarcinoma ( Table 2).…”

Section: Resultsmentioning

confidence: 99%

“…Pearson and Fitzgerald were the first to report the high incidence (23%) of second primary malignancies (SPM) in patients with small intestinal NETs at autopsy [27]. A certain number of NETs were incidentally found during surgery for other [7] 1972 53 M Rectum Rectum -Lotlikar et al [25] 1981 53 M Rectum Small bowel -Lotlikar et al [25] 1981 67 F Right colon Small bowel -Lotlikar et al [25] 1981 60 F Sigmoid colon Small bowel -Sacchi et al [8] 1988 57 M Right colon Small bowel -Tse et al [9] 1997 72 M Hepatic flexure Small bowel -Habal et al [28] 2000 52 M Sigmoid colon Rectum Cioffi et al [10] 2005 64 F Ileum Small bowel -Klucinski et al [11] 2006 72 F Transverse colon Small bowel -Chemli et al [12] 2007 63 F Right colon Small bowel -Aslam et al [13] 2009 67 F Sigmoid colon Small bowel G1 Boland et al [14] 2009 77 F Left colon Meckel's diverticulum -McHugh et al [15] 2009 74 F Rectum Small bowel -Wohadlo et al [29] 2011 53 M Splenic-hepatic flexure Small bowel -Gurzu et al [16] 2012 78 F Sigmoid colon Small bowel G3 Pozzato et al [17] 2012 61 M Right colon Duodenum G1 Katalinic 2014 et al [18] 2014 63 M Right colon Meckel's diverticulum G1 Zhu et al [19] 2015 64 F Rectum Rectum G1 Almajano et al [20] 2016 66 M Right colon Small bowel G1 Mohapatra et al [21] 2016 83 M Sigmoid colon Left colon G3 Nejatollahi et al [22] 2016 83 M Sigmoid colon Small bowel G1 Vootla et al [23] 2016 46 F Hepatic flexure Rectum G1 Winn et al [30] 2017 40 M Sigmoid colon Rectum G1 Winn et al [30] 2017 70 M Sigmoid colon Rectum G1 Napolitano et al [24] 2017 72 M Right colon Small bowel G1-G2 cancers. The estimated rate of SPM associated with other malignancies was 2.3% in surgical cases and 8.1% in autopsy cases [42].…”

Section: Discussionmentioning

confidence: 99%

A rare case of metachronous neuroendocrine tumor after a colorectal adenocarcinoma: qualitative critical review of synchronous and metachronous gastrointestinal NET

Lancellotti

Solinas

Telesco

et al. 2020

Clin J Gastroenterol

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Gastrointestinal neuroendocrine tumor (NET) associated with a metachronous intestinal adenocarcinoma is rare. We report the case of a 71-year-old man with an ileal NET. Patient has previously undergone a left colectomy for sigmoid cancer. We report a complete review both of the metachronous and synchronous NET. A comprehensive systematic literature search in PubMed, EMBASE, and MEDLINE identified a total of 35 relevant studies. This study includes an analysis of review articles, case reports, case series, retrospective studies and population-based studies. In the English literature to date, there are 21 case reports (19 synchronous cases and 2 metachronous cases), 3 case series and 3 review articles, and less than 10 retrospective studies or population-based studies. A total of 31 patients in 24 articles were included in the study: 28 patients with a synchronous gastrointestinal NET and colorectal adenocarcinoma and 3 patients with metachronous gastrointestinal NET and colorectal adenocarcinoma. The incidence of synchronous cancer (particularly for colorectal and gastric cancer) with a gastrointestinal NET ranges from 10 to 50%, while for the metachronous ones it is still unclear. This is the third metachronous case report and the first descriptive case of gastrointestinal NET diagnosed 2 years after a colorectal adenocarcinoma. An endoscopic follow-up program for gastrointestinal NET patients and/or for first-degree relatives of NET patients appears recommendable.

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Linfoma de Hodgkin anal primario y tumor neuroendocrino intestinal sincrónicos: a propósito de un caso y revisión de la literatura.

Vilela

Barroso

Armas-Conde

et al. 2021

Rev. colomb. cancerol.

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La localización extranodal gastrointestinal del linfoma de Hodgkin comprende el 5% de todos los linfomas. Dentro de este grupo, el linfoma anal primario representa menos del 0,05%, siendo por tanto una entidad extremadamente rara. Por otro lado, los tumores neuroendocrinos son un grupo heterogéneo de neoplasias relativamente poco frecuentes, pero de localización fundamentalmente digestiva. La asociación entre un linfoma de Hodgking de localización anal y un tumor neuroendocrino intestinal no ha sido descrita previamente en la literatura, pero no es en absoluto raro que los tumores neuroendocrinos puedan coexistir con otro tipo de neoplasias. Los autores presentan el caso infrecuente de presentación de linfoma Hodgkin de localización anal asociado a un tumor neuroendocrino intestinal en una paciente mujer de 74 años, describiéndose la clínica, resultados de pruebas complementarias y tratamiento recibido.

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Tumor neuroendocrino bien diferenciado ileal y adenocarcinoma de colon sincrónicos: a propósito de un caso y revisión de la literatura

Cited by 3 publications

References 10 publications

Neuroendocrine neoplasms of gastrointestinal tract and secondary primary synchronous tumors: A systematic review of case reports. Casualty or causality?

Neuroendocrine neoplasms of gastrointestinal tract and secondary primary synchronous tumors: A systematic review of case reports. Casualty or causality?

A rare case of metachronous neuroendocrine tumor after a colorectal adenocarcinoma: qualitative critical review of synchronous and metachronous gastrointestinal NET

Linfoma de Hodgkin anal primario y tumor neuroendocrino intestinal sincrónicos: a propósito de un caso y revisión de la literatura.

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