1997
DOI: 10.1378/chest.111.4.885
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Tumor Neutrophil Elastase Is Closely Associated With the Direct Extension of Non-small Cell Lung Cancer Into the Aorta

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Cited by 46 publications
(29 citation statements)
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“…The distribution of patients with predicted intermediate and high activity was almost equal (43% vs. 47%, respectively). This data suggest that intermediate and high NE activity could play a role in LC, which is in concordance with results of Yamashita and co-workers who showed that elevated levels of NE facilitate the invasion of cancer cell [26].…”
Section: Discussionsupporting
confidence: 92%
“…The distribution of patients with predicted intermediate and high activity was almost equal (43% vs. 47%, respectively). This data suggest that intermediate and high NE activity could play a role in LC, which is in concordance with results of Yamashita and co-workers who showed that elevated levels of NE facilitate the invasion of cancer cell [26].…”
Section: Discussionsupporting
confidence: 92%
“…Surgical stress induces organ dysfunction through an uncontrolled inflammatory response, due to the overproduction of proinflammatory mediators (12,13) by macrophages and lymphocytes. In clinical practice, we often experience cases of rapid recurrence or regrowth of tumors after major cancer surgery, or perioperative surgical complications with inflammatory responses that involve the release of NE by neutrophils and also by cancer cells, as reported by Yamashita et al (15)(16)(17) Given these perioperative and oncological circumstances, we have focused on the NE that is released from neutrophils and tumor cells.…”
Section: Discussionmentioning
confidence: 99%
“…A previous study suggests that individuals with elastolytic damage in lung tissue may have a higher risk for lung cancer than those with normal lung tissue [1]. NE was associated with aggressiveness of the tumor, suggesting its involvement in the invasion of the tumor and association with poor prognosis in non-small cell lung cancer [7].…”
Section: Introductionmentioning
confidence: 97%