Tumor oxygenation in a transplanted rat rhabdomyosarcoma during fractionated irradiation

Zywietz, F.; Reeker, W.; Kochs, Eberhard

doi:10.1016/0360-3016(94)00653-3

Cited by 51 publications

(35 citation statements)

References 33 publications

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“…For the R1H-tumor an increase of hypoxia as measured using polarographic needle probes and the Eppendorf pO 2 -device with treatment time [24], as well as a severe energy depletion has been described [17]. These changes might be a result of destruction of tumor blood vessels [23] and might also explain the observed decrease of radiosensitivity during fractionated treatment.…”

Section: Discussionmentioning

confidence: 99%

Impact of Treatment Acceleration and its Timing on the Response of the Rhabdomyosarcoma R1H of the Rat to Fractionated Irradiation

et al. 2001

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Section: Discussionmentioning

confidence: 99%

Impact of Treatment Acceleration and its Timing on the Response of the Rhabdomyosarcoma R1H of the Rat to Fractionated Irradiation

et al. 2001

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“…The dose recovered per day determined from these data was 1 Gy. It was considered most likely that the increase of TCDs0 with increasing overall treatment time in FaDu tumors was caused by repopulation of clonogenic tumor cells [13,24,27,31], however, other mechanisms such as a time-dependent increase of the hypoxic cell fraction [7,34,35] could not be ruled out by these experiments. The detrimental effect of prolonging overall treatment time on local control of FaDu tumors was confirmed in the present investigation ( Figure 2, Table 2).…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Response of human FaDu squamous cell carcinoma in nude mice after hypofractionated-accelerated regimens and “curative” fractionation schedules

et al. 1998

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The results of the present study compare well with our previous findings after different "curative" fractionation schedules in the same tumor. Thus, our study does not support that tumors respond differently after application of 10 or more fractions compared to less fractionated regimens. The biological mechanisms that govern the radiation response of FaDu tumors appear to be the same for hypofractionated-accelerated and "curative" regimens. Since only one tumor was investigated, these results cannot be generalized at the present time.

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“…Even though neither the single large dose treatment nor the fractionated irradiation could produce any complete or partial regression, the fractionated RT significantly increased the growth delay (by almost 12 days) from the single dose treatment. The higher tumor response observed in tumors exposed to fractionated RT could be attributed to reoxygenation of hypoxic cells in between the fractions, 10 making them more radiosensitive.…”

Section: Discussionmentioning

confidence: 99%

Enhancement of the Response of B16F1 Melanoma to Fractionated Radiotherapy and Prolongation of Survival by Withaferin A and/or Hyperthermia

Kalthur

Pathirissery

2010

Integr Cancer Ther

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Withaferin A (WA), isolated from Indian medicinal plant Withania somnifera has weak antitumor and radiosensitizing property. The present investigation was planned to evaluate the tumor sensitizing effect of WA with or without local hyperthermia on the response of B16F1 melanoma to fractionated and acute radiotherapy. C57BL mice bearing tumors of 100 ± 10mm3 were treated with fractionated radiotherapy (RT, 2Gy x 5 days/week, 4 weeks), withaferin A (15mg/kg, i.p., 5 days/ week, 3 weeks), local hyperthermia (HT, 43°C once a week, 3 weeks) and their combinations, or acute RT (40Gy), WA (40mg/kg), HT (43°C, 30min) and their combinations. Treatment response was studied by tumor regression, growth delay and animal survival. Acute RT+HT produced 50% partial response which increased to 62.5% with combination of WA. In fractionated regimen, trimodality combination resulted in 100% PR. Acute RT+HT and WA+RT produced similar increase in growth delay (GD) compared to RT alone which further increased in trimodality treatment. Fractionated WA+RT+HT for 3 weeks produced a higher GD and survival than all other treatments. In conclusion, WA is a better radiosensitizer than HT in fractionated regimen and the response of radioresistant tumors like melanoma can be significantly enhanced by combining nontoxic doses of WA with fractionated RT, with or without HT, allowing decrease in radiation dose.

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Tumor oxygenation in a transplanted rat rhabdomyosarcoma during fractionated irradiation

Cited by 51 publications

References 33 publications

Impact of Treatment Acceleration and its Timing on the Response of the Rhabdomyosarcoma R1H of the Rat to Fractionated Irradiation

Impact of Treatment Acceleration and its Timing on the Response of the Rhabdomyosarcoma R1H of the Rat to Fractionated Irradiation

Comparison of the Response of human FaDu squamous cell carcinoma in nude mice after hypofractionated-accelerated regimens and “curative” fractionation schedules

Enhancement of the Response of B16F1 Melanoma to Fractionated Radiotherapy and Prolongation of Survival by Withaferin A and/or Hyperthermia

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