Tumor Oxygenation Under Normobaric and Hyperbaric Hyperoxia

Thews, Oliver; Kelleher, Debra K.; Vaupel, Peter

doi:10.1007/978-1-4615-5399-1_12

Cited by 7 publications

(2 citation statements)

References 26 publications

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“…Mean PO2 Ϯ SD for the histogram is 1.5 Ϯ 1.0 mmHg, with a median of 1. creasing the O 2 content of the blood. One of the simplest methods of increasing blood O 2 content is having the animal or patient breathe 100% O 2 , and this has been studied as a potential means of increasing tumor PO 2 levels (34).…”

Section: Tumor Po 2 Responses To Glucose or 100% O 2 Breathingmentioning

confidence: 99%

“…Most studies looking at O 2 changes in experimental tumors in response to 100% O 2 breathing have measured tumor PO 2 histograms with the Eppendorf electrode system and have either shown an increase in median tumor PO 2 and a decrease in hypoxic fraction (34,26) or no change in median PO 2 or hypoxic fraction (2) during hyperoxia. In one study (34), transient changes at a single point were also measured using a catheter PO 2 electrode with an unspecified diameter. Tumor PO 2 rose from near 10 mmHg to ϳ70 mmHg during 100% O 2 breathing.…”

Section: Tumor Po 2 Responses To Glucose or 100% O 2 Breathingmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents

Braun

Lanzen

Snyder

et al. 2001

American Journal of Physiology-Heart and Circulatory Physiology

256

181

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In this study we compare oxygen tension (PO2) histograms measured with O2 microelectrodes and a new optical PO2 measurement device, the OxyLite, in normal tissues (mouse spleen and thymus) and in tumors (R3230Ac in rats) (n = 5-6). The transient response to glucose infusion or 100% O2 breathing (hyperoxia) was also measured in tumors. PO2 histograms of spleen and thymus with the two devices were not different. The OxyLite tumor PO2 histogram, however, was left-shifted compared with the microelectrode (median PO2 1.0 vs. 4.0 mmHg, P = 0.016). Both probes responded to acute hyperglycemia with a mean increase of 3-6 mmHg, but the microelectrode change was not significant. The OxyLite consistently recorded large PO2 increases (approximately 28 mmHg) with hyperoxia, whereas the microelectrode response was variable. The OxyLite averages PO2 over an area that contains interstitial and vascular components, whereas the microelectrode measures a more local PO2. This study demonstrates the importance of considering the features of the measurement device when studying tissues with heterogeneous PO2 distributions (e.g., tumors).

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Section: Tumor Po 2 Responses To Glucose or 100% O 2 Breathingmentioning

confidence: 99%