Tumor prevalence and biomarkers of exposure in brown bullheads (<i>Ameiurus nebulosus</i>) from the tidal Potomac River, USA, watershed

Pinkney, Alfred E.; Harshbarger, John C.; May, Eric; Melancon, Mark J.

doi:10.1002/etc.5620200608

Cited by 44 publications

(80 citation statements)

References 32 publications

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“…Such an observation is not unexpected and most likely reflects normal shifts in reproductive physiology, and has been reported previously (Yang et al 2006). While increased HSI has been used as an indicator of contaminant-associated (Fabacher and Baumann 1985;Pinkney et al 2001), this biomarker did not support evidence of differences between rivers in the present study. Reduced condition factor (Ktl) in wild species inhabiting ecosystems contaminated with organochlorines have been previously reported (Rocha and Monteiro 1999;Anderson et al 2003).…”

Section: Discussioncontrasting

confidence: 75%

“…Skin tumors, including papillomas and squamous cell carcinomas have been used as indicators of chemical exposure in brown bullhead and other species (Grizzle et al 1981;Smith et al 1989;Black and Baumann 1991;Pinkney et al 2001;Blazer et al 2009a). Although no cause-and-effect correlations have been made in wild populations, papillomas have been experimentally induced in brown bullhead by repeated dosing of the skin with sediment extracts with high levels of PAHs (Black et al 1985).…”

Section: Discussionmentioning

confidence: 98%

“…This benthic life history leads to chronic, intimate contact with potentially contaminated sediment and makes it an exemplary species for biological heath assessments (Baumann 1984;Pinkney et al 2001). The LMB is a pelagic, top carnivore of commercial and recreational importance.…”

Section: Species and Sitesmentioning

confidence: 99%

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Histologic, immunologic and endocrine biomarkers indicate contaminant effects in fishes of the Ashtabula River

et al. 2011

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The use of fish as sentinels of aquatic ecosystem health is a biologically relevant approach to environmental monitoring and assessment. We examined the health of the Ashtabula River using histologic, immunologic, and endocrine biomarkers in brown bullhead (BB; Ameiurus nebulosus) and largemouth bass (Micropterus salmoides) and compared fish collected from a reference site (Conneaut Creek). Seasonal analysis was necessary to distinguish differences in fish between the two rivers. Overall BB from the Ashtabula River had a lower condition factor and significantly more macrophage aggregates than those from the reference site. Reduced bactericidal and cytotoxic-cell activity was observed in anterior kidney leukocytes from both BB and largemouth bass from the Ashtabula River. Lower plasma thyroxine and triiodo-L-thyronine in both species in the Ashtabula River indicated disruption of the thyroid axis. Differences in physiological biomarker responses were supported by body burden chemical concentrations when data were analyzed on a seasonal basis. The use of two fish species added a level of rigor that demonstrated biological effects were not exclusive to a single species. The results provide strong evidence that contaminants have affected fish in the Ashtabula River, a Great Lakes Area of Concern, and provide a baseline by which to evaluate remediation activities.

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Section: Discussioncontrasting

confidence: 75%

Section: Discussionmentioning

confidence: 98%

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Histologic, immunologic and endocrine biomarkers indicate contaminant effects in fishes of the Ashtabula River

et al. 2011

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“…However, for S. jello, Vijayakumar et al (2014) reported a prevalence of 12.1%, which was much higher than the overall prevalence of 0.37% that we found among S. jello. Sex can be an important factor in tumour prevalence in fish, with females at higher risk than males (Baumann et al 1990, Pinkney et al 2001, 2004. In the present study, we observed a higher incidence among females than among males.…”

Section: Discussionsupporting

confidence: 57%

Oral neoplasms in pickhandle barracuda Sphyraena jello from India

Singaravel

Gopalakrishnan²,

Raja³

et al. 2017

Dis. Aquat. Org.

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We report the spontaneous occurrence of oral neoplasms in pickhandle barracuda Sphyraena jello Cuvier, 1829 from Parangipettai, on the southeast coast of India. A total of 11736 fish were examined, of which 43 were affected with oral tumours, with an overall prevalence of 0.37%. Gross and clinical symptoms included reddish to grayish-white distended tumourous growths on the gingiva, intra-oral bones and tongue. The tumours exhibited delayed eruption and intra-or extra-oral swelling, varied in consistency from extremely firm to fleshy and released mucinous material. The majority of tumours consisted of numerous clumped toothlets, but some included hardened tissues. Local area invasion/transmission was observed in most cases; however, necropsy examination revealed no gross evidence of distant metastasis into visceral organs. Radiographic examination of compound odontomas revealed distinct unilocular radio-opaque minitoothlets surrounded by defined radiolucency, whereas complex odontomas exhibited unilocular and indistinct radio-opaque masses within a much more extensive radiolucent zone. Histopathologically, the intra-oral tumour lesions were characterized by numerous imperfect (germ) toothlets consisting of a disorganized combination of dental tissues: pulp tissues with manifested and predominantly mixed hard dental tissues of immature dentine and enamel, numerous small to large and round to polyhedral ossicles embedded in hypocellular fibrous stromal tissues and sparsely spaced bland spindloid cells with cleft-like spaces of loose mucoid stroma. Histochemically, the neoplastic lesions stained positive for periodic acid-Schiff and Masson's trichrome. Based on the clinical and histological findings, the tumours were diagnosed as compound odontomas, complex odontomas, odontogenic myxomas, lingual myxomas and psammomatoid ossifying fibromas.

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“…Numerous studies have documented elevated levels of chemical contaminants in sediments, surface waters and fish tissue throughout the river (Foster et al 2000;McGee et al 2009;Velinsky et al 1994;Wade et al 1994) and their impact to fish and benthic biota (McGee et al 2009;Pinkney et al 2004;Schlekat et al 1994;Velinsky and Cummins 1996). In the past decade, the District of Columbia and State of Maryland have implemented assessments and control programs that are geared to reducing the inputs of many contaminants and begin to restore the river.…”

Section: Introductionmentioning

confidence: 96%

Historical contamination of the Anacostia River, Washington, D.C.

Velinsky¹,

Riedel

Ashley

et al. 2011

Environ Monit Assess

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The tidal Anacostia River in Washington DC has long been impacted by various sources of chemical pollution over the past 200 years. To explore more recent inputs of various chemicals, six sediment cores were collected for dating and chemical analysis in the downstream section of the tidal Anacostia River. Profiles of contaminants in sediment cores can be useful in determining management direction and effectiveness of pollution controls over time. There were two main objectives for this investigation: (1) determine current sediment contaminant levels; (2) determine a historical perspective of the sediment changes in contamination using (137)Cs and (210)Pb dating. The determination of an age-depth relationship using (210)Pb and (137)Cs dating gave somewhat different results, suggesting that the assumptions of (210)Pb dating were not met. Using the (137)Cs horizon allowed an assignment of approximate sediment accumulation rates and hence an age-depth relationship to contaminant events in the upper portions of the cores. Total PAHs showed higher concentrations at depth and lower surface concentrations. In the upper sections, PAHs were a mixture of combustion and petrogenic sources, while at depth the signature appeared to be of natural origins. Total PCBs, DDTs and chlordane concentrations showed a maximum in recent sediments, decreasing towards the surface. PCBs had lower molecular weight congeners near the surface and higher molecular weights at depth. A phthalate ester, DEHP, appeared in the mid 1940-1950s, and decreased towards the surface. Trace elements fell roughly into three groups. Fe, Mn, and As were in approximately constant proportion to Al, except in some deeper, sandy sediments, where they showed enrichments linked to redox conditions. Ag, Cd, Cu, Hg, Pb, and Zn had low concentrations in the deepest sediments, high concentrations at mid-depths, and declines to intermediate levels at the surface. Ni and Cr followed neither of these patterns closely. We observed that many contaminants appeared in the Anacostia sediments at various times, and reached relatively high concentrations in the past, but are now showing declines in loadings. In some cases, such as PCBs, DDT, chlordane, and Pb from leaded gasoline, these declines can be clearly linked to the discontinuation of their use for environmental reasons. For other contaminants (e.g., PAHs, DEHP, selected metals) these declines are more likely the result of changes in production, usage and waste control.

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Tumor prevalence and biomarkers of exposure in brown bullheads (Ameiurus nebulosus) from the tidal Potomac River, USA, watershed

Cited by 44 publications

References 32 publications

Histologic, immunologic and endocrine biomarkers indicate contaminant effects in fishes of the Ashtabula River

Histologic, immunologic and endocrine biomarkers indicate contaminant effects in fishes of the Ashtabula River

Oral neoplasms in pickhandle barracuda Sphyraena jello from India

Historical contamination of the Anacostia River, Washington, D.C.

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