2002
DOI: 10.1002/ijc.10778
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Tumor regression mechanisms by IL‐13 receptor–targeted cancer therapy involve apoptotic pathways

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Cited by 13 publications
(9 citation statements)
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“…Complete inhibition of ETA-induced ssDNA formation and D4-GDI cleavage by Z-VAD-fmk suggests an essential role of the caspasedependent pathway in ETA-induced mast cell apoptosis. This finding is supported by others (7,42) who demonstrate caspase-3-like activities induced by immunotoxins or chimeric proteins with growth factors such as interleukin-13 (11,43). These chimeric products, however, may involve additional mechanisms such as Fc receptors (immunotoxins) or growth factor receptors such as interleukin-13 receptors and other factors, in addition to toxin-mediated effects.…”
Section: Figsupporting
confidence: 56%
See 1 more Smart Citation
“…Complete inhibition of ETA-induced ssDNA formation and D4-GDI cleavage by Z-VAD-fmk suggests an essential role of the caspasedependent pathway in ETA-induced mast cell apoptosis. This finding is supported by others (7,42) who demonstrate caspase-3-like activities induced by immunotoxins or chimeric proteins with growth factors such as interleukin-13 (11,43). These chimeric products, however, may involve additional mechanisms such as Fc receptors (immunotoxins) or growth factor receptors such as interleukin-13 receptors and other factors, in addition to toxin-mediated effects.…”
Section: Figsupporting
confidence: 56%
“…Because of its potent cytotoxicity, ETA has been widely used to generate fusion proteins to kill target cells. For example, chimeric cytotoxins have been constructed by the fusion of growth factors or antibodies with the enzymatic region of ETA to specifically target and eliminate cancer cells, virally infected cells, or mast cells (7)(8)(9)(10)(11)(12). It is generally accepted that ETA is internalized by the cell surface receptor CD91 (the ␣2-macroglobulin receptor/low density lipoprotein receptor-related protein) (13) and asserts its cellular toxicity by blocking protein synthesis through ADP ribosylation of translation elongation factor 2 (14 -16).…”
mentioning
confidence: 99%
“…In addition, IL-13 cytotoxin has been shown to exhibit potent antitumor activity in vitro and in vivo in many tumor models, including SCC. 22,[26][27][28][29][30] To demonstrate the therapeutic efficacy of the IL-13 cytotoxin (IL13-PE38), which is composed of IL-13 and a truncated form of Pseudomonas exotoxin, [26][27][28] as an antitumor agent we assessed its cytotoxicity on primary cultures established from SCCs in TβRI COKO mice.…”
Section: Introductionmentioning
confidence: 99%
“…These molecules are found to be highly cytotoxic to tumor cells expressing IL-13R in vitro (1,7,8,10,18) and exhibit a potent antitumor activity in vivo in athymic nude mouse models of human cancers (19 -22). IL-13 cytotoxin mediated apoptotic and necrotic cell death in head and neck tumor in vitro and in vivo (23,24). Based on these preclinical results, Phase I/II clinical trials are currently ongoing to evaluate its safety, tolerability, and efficacy in patients with recurrent glioblastoma multiforme (25)(26)(27).…”
Section: Introductionmentioning
confidence: 99%