Tumor resection reduced circulating tumor cell dissemination

Abstract

Background: Cancer is a major public health problem worldwide. Whether to perform tumor resection or non-resection remains controversial face different types. Circulating tumor cells (CTCs) which are classified into three subpopulations epithelial (E-CTC), mesenchymal (M-CTC), and epithelial mesenchymal (E/M-CTC) based on expression of specificity biomarker.Methods: We identified CTCs using CanPatrol CTC enrichment technique from peripheral blood samples of 930 patients with tumor resection or non-resection. Patients were divided into two groups: Resection (n=615) and Non-resection (n=315). The relationship between tumor resection and count of CTCs were studied by using correlation analysis.Results: The mean patient age was 57.52 years (range, 17–87 years). Univariate analysis tumor resection could significantly reduce the number of total CTC cells (hazard ratio，HR, 0.92, 95% confidence interval, CI= 0.903-0.937; P < 0.001), the E-CTC cells (HR, 0.889, 95% CI= 0.837-0.944; P < 0.001), the M-CTC cells (HR, 0.799, 95% CI= 0.735-0.869; P < 0.001), and the E/M-CTC cells (HR, 0.908, 95% CI= 0.888-0.928; P < 0.001).Furthermore, correlation analysis between total CTC and E-CTC, M-CTC, and E/M-CTC, the pearson correlation coefficient was 0.467, 0.458, and 0.963, respectively.Conclusions: In conclusion，the tumor resection can reduce the number of CTCs in peripheral blood.