Tumor seeding after endoscopic ultrasound-guided fine-needle aspiration of cancer in the body of the pancreas

Ultrasound-guided percutaneous fine-needle aspiration of solid pancreatic neoplasms: 10-year experience with more than 2,000 cases and a review of the literature

“…It must be noted, however, that Johnson et al [21] found no difference in median survival between patients with pancreatic cancer who underwent percutaneous FNA and those who did not; Hernandez et al strengthened these findings in their 1,406-patient review [22]. Moreover, the small number of cases of peritoneal seeding after FNA published thus far suggests that this complication is more common after EUS-FNA, especially when the sample is performed on cystic lesions [23][24][25]. It must be also noted that a reliable distinction between peritoneal nodules secondary to disease progression and those induced by peritoneal seeding following FNA can be hard to achieve, even at laparotomy [26].…”

Preoperative endoscopic ultrasound-guided fine needle aspiration does not impair survival of patients with resected pancreatic cancer

“…The concerns over cancer cell seeding along the needle track or within the peritoneum caused by EUS-FNA of pancreatic lesions have arisen from numerous case reports 4 5 6 14 15. In a retrospective study of 175 patients with intraductal papillary mucinous neoplasm, EUS-FNA did not increase the frequency of postoperative peritoneal seeding 16.…”

Utility of “liquid biopsy” using pancreatic juice for early detection of pancreatic cancer

“…Although tissue collection by EUS-FNA/B is a standard procedure for providing histological evidence of the tumor, the possibility of procedure-related dissemination has to be borne in mind, specifically for candidates with a high probability of a cure 12 . A genetic test may compensate for the invasiveness with variable sensitivity and specificity depending on the source of the samples (i. e. plasma, duodenal and pancreatic juice, and other body fluids).…”