Tumor Seeding With Renal Cell Carcinoma After Renal Biopsy

Andersen, Mikkel; Norus, Thomas

doi:10.1016/j.eucr.2016.08.008

Cited by 37 publications

(28 citation statements)

References 5 publications

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“…Interestingly, almost all cases of seeding reported to date have been associated with PRCC, which may relate to structural features particular to this tumour type 13 . There are now two published cases, including one in our own series, in which there has been subsequent histologically proven local tumour recurrence at a site consistent with prior RTB 3,4 . Furthermore, a recent review of almost 25000 clinical T1a RCC cases from the US National Cancer Database reported an association between RTB and upstaging due to perinephric fat involvement (2.1% among RTB patients versus 1.1% among non‐RTB patients, P < 0.01) and that upstaging was associated with poorer overall survival 14 .…”

Section: Figurementioning

confidence: 74%

“…Current guidelines suggest RTB tract seeding by tumour to be rare 2 . However, there are now several case reports of this, including one with histologically confirmed local recurrence 3 . We recently published a series of seven patients with histological evidence of tumour seeding of the RTB tract within the perinephric fat of the subsequent resection specimen, 4 the incidence in our institution being 1%.…”

Section: Figurementioning

confidence: 90%

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Tumour seeding of the renal tumour biopsy tract – a histologically under‐recognised feature?

et al. 2020

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Section: Figurementioning

confidence: 74%

Section: Figurementioning

confidence: 90%

Tumour seeding of the renal tumour biopsy tract – a histologically under‐recognised feature?

et al. 2020

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“…Despite a high positive predictive value, there are concerns regarding accuracy, low negative predictive value, relatively high non‐diagnostic rate, difficulties in interpreting histological subtypes, the occurrence of hybrid lesions, and significant tumour heterogeneity 26 , 27 . Seeding of malignant cells along the biopsy tract is a rare complication, with only eight cases reported 28 …”

Section: Current Standard Of Carementioning

confidence: 99%

“…u 4 Bosniak classification system of cystic renal masses 19,20 26,27 Seeding of malignant cells along the biopsy tract is a rare complication, with only eight cases reported. 28…”

Section: Renal Mass Biopsymentioning

confidence: 99%

Optimising assessment of kidney function when managing localised renal masses

Ellis

Joshi

et al. 2017

Medical Journal of Australia

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Increased early and incidental detection, improved surgical techniques and technological advancement mean that the management of renal mass lesions is constantly evolving. The treatment of choice for renal mass lesions has historically been radical nephrectomy. Partial nephrectomy is now recommended for localised renal masses, owing to favourable renal functional outcomes. Ablative renal surgery confers a significant risk of chronic kidney disease. There are few studies assessing long term outcomes of nephrectomy on renal outcomes, and virtually no studies assessing long term outcomes for less invasive therapies such as ablation. Unless a renal mass is clearly benign on imaging, management decisions will be made with an assumption of malignancy. The content of this review applies to both benign and malignant renal mass lesions. We advocate for improved strategies for kidney function assessment and risk stratification, early targeted referral, and regular screening for chronic kidney disease for all patients after surgery.

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“…Outside of rare reports, this remains consistent with the current body of evidence. 22,23 In addressing the limitations of our study, we identify that this is in fact a retrospective series. The evaluation of renal biopsy will require prospectively randomized data before definitive guidelines can be established.…”

Section: Cuaj -Original Researchmentioning

confidence: 99%

Evaluating the role for renal biopsy in T1 and T2 renal masses: A single-centre study

Hoare

Evans

Richards

et al. 2018

CUAJ

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Introduction: Once used primarily in the identification of renal metastasis and lymphomas, various urological bodies are now adopting an expanded role for the renal biopsy. We sought to evaluate the role of the renal biopsy in a Canadian context, focusing on associated adverse events, radiographic burden, and diagnostic accuracy. Methods: This retrospective review incorporated all patients undergoing ultrasound (US)/computed tomography (CT)-guided biopsies for T1 and T2 renal masses. There were no age or lesion size limitations. The primary outcome of interest was the correlation between initial biopsy and final surgical pathology. A binomial logistic regression analysis was conducted to determine any confounding factors. Secondary outcomes included the accuracy of tumour cell typing, grading, the safety profile and radiographic burden associated with these patients. Results: 148 patients satisfied inclusion criteria for this study. Mean age and lesions size at detection were 60.9 years (±12.4) and 3.6 cm (±2.0), respectively. Most renal masses were identified with US (52.7%) or CT (44.6%). Three patients (2.0%) experienced adverse events of note. Eighty-six patients (58.1%) proceeded to radical/partial nephrectomy. Our biopsies held a diagnostic accuracy of 90.7% (sensitivity 96.2%, specificity 87.5%, positive predictive value 98.7%, negative predictive value 70.0%, kappa 0.752, p<0.0005). Binomial logistic regression revealed that age, lesion size, number of radiographic tests, time to biopsy, and modality of biopsy (US/CT) had no influence on the diagnostic accuracy of biopsies. Conclusions: Renal biopsies are safe, feasible, and diagnostic. Their role should be expanded in the routine evaluation of T1 and T2 renal masses.

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Tumor Seeding With Renal Cell Carcinoma After Renal Biopsy

Abstract: Tumor seeding following biopsy of renal cell carcinoma is extremely rare with an incidence of 1:10.000. In this paper two cases with multiple recurrent RRC metastasis in the biopsy tract following biopsy of renal tumor is presented and the current literature is shortly discussed.

Cited by 37 publications

References 5 publications

Tumour seeding of the renal tumour biopsy tract – a histologically under‐recognised feature?

Tumour seeding of the renal tumour biopsy tract – a histologically under‐recognised feature?

Optimising assessment of kidney function when managing localised renal masses

Evaluating the role for renal biopsy in T1 and T2 renal masses: A single-centre study

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