Tumor-selective near-infrared photodynamic therapy with novel indocyanine green-loaded nanocarrier delays paralysis in rats with spinal metastasis

Funayama, Toru; Tsukanishi, Toshinori; Hara, Isao; Ozeki, Eiichi; Sakane, Masataka

doi:10.1016/j.pdpdt.2013.03.002

Cited by 11 publications

(11 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In conclusion, the present results suggest that ICG-lactosome is useful as a novel diagnostic and therapeutic agent for HCC, similar to the case for peritoneal dissemination in gastric cancer [ 23 ], spinal metastasis [ 24 – 26 ], lymph node metastases in gastric cancer [ 27 ], and metastatic bone tumors in human breast cancer [ 30 ]. PDT using ICG-lactosome can be repeatedly performed and can be used in endoscopic or laparoscopic therapy for small HCC.…”

Section: Discussionsupporting

confidence: 71%

“…Using ICG-lactosome, investigators can diagnose or treat a variety of tumors by fluorescence imaging or PDT, respectively. Funayama et al [ 24 – 26 ] reported that ICG-lactosome selectively accumulated in spinal metastasis, and that PDT using ICG-lactosome delayed the development of paralysis in a rat spinal metastasis model. Tsujimoto et al [ 23 , 27 ] reported a comparison of the diagnostic and treatment effects of ICG and ICG-lactosome.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Near-infrared fluorescence imaging and photodynamic therapy with indocyanine green lactosome has antineoplastic effects for hepatocellular carcinoma

et al. 2017

Self Cite

View full text Add to dashboard Cite

BackgroundAnticancer agents and operating procedures have been developed for hepatocellular carcinoma (HCC) patients, but their prognosis remains poor. It is necessary to develop novel diagnostic and therapeutic strategies for HCC to improve its prognosis. Lactosome is a core-shell-type polymeric micelle, and enclosing labeling or anticancer agents into this micelle enables drug delivery. In this study, we investigated the diagnostic and therapeutic efficacies of indocyanine green (ICG)-loaded lactosome for near-infrared fluorescence (NIF) imaging and photodynamic therapy (PDT) for HCC.MethodsThe human HCC cell line HuH-7 was treated with ICG or ICG-lactosome, followed by PDT, and the cell viabilities were measured (in vitro PDT efficiency). For NIF imaging, HuH-7 cells were subcutaneously transplanted into BALB/c nude mice, followed by intravenous administration of ICG or ICG-lactosome. The transplanted animals were treated with PDT, and the antineoplastic effects were analyzed (in vivo PDT efficiency).ResultsPDT had toxic effects on HuH-7 cells treated with ICG-lactosome, but not ICG alone. NIF imaging revealed that the fluorescence of tumor areas in ICG-lactosome-treated animals was higher than that of contralateral regions at 24 h after injection and thereafter. PDT exerted immediate and continuous phototoxic effects in the transplanted mice treated with ICG-lactosome.ConclusionsOur results demonstrate that ICG-lactosome accumulated in xenograft tumors, and that PDT had antineoplastic effects on these malignant implants. NIF imaging and PDT with ICG-lactosome could be useful diagnostic and/or therapeutic strategies for HCC.

show abstract

Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Near-infrared fluorescence imaging and photodynamic therapy with indocyanine green lactosome has antineoplastic effects for hepatocellular carcinoma

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…This research demonstrated that ICG-lactosomes accumulated in xenograft tumors and that PDT had an antitumor effect on malignant tumors. Funayama et al reported that ICG-lactosomes selectively accumulated in spinal cord metastasis and PDT using ICG-lactosomes delayed the onset of paralysis in a rat spinal cord metastasis model [16–18]. Hirano et al reported a comparison of the diagnostic and therapeutic effects of ICG and ICG-lactosomes [6].…”

Section: Discussionmentioning

confidence: 99%

Near-infrared fluorescence imaging and photodynamic therapy with indocyanine green lactosomes has antineoplastic effects for gallbladder cancer

et al. 2019

Self Cite

View full text Add to dashboard Cite

BACKGROUND: The diagnostic use and therapeutic effect of near infrared fluorescence (NIF) imaging and photodynamic therapy (PDT) was investigated for gallbladder cancer using indocyanine green (ICG)-lactosomes. RESULTS: PDT was toxic for NOZ cells treated with ICG-lactosomes. Fluorescence intensity in the tumor region of mice administered ICG-lactosomes, but not ICG alone, was higher than the healthy contralateral region ≥24 hours after injection. PDT exerted immediate and continuous phototoxic effects in NOZ implanted mice injected with ICG-lactosomes. Enhanced antitumor effects were observed in the twice irradiated group compared with the once irradiated group. METHOD: ICG or ICG-lactosomes were added to the human gallbladder cancer cell line NOZ followed by PDT and cell viability was measured. Mass spectrometry of ICG and ICG-lactosomes was performed after PDT. ICG or ICG-lactosomes were intravenously administered to BALB/c nude mice implanted subcutaneously with NOZ cells and fluorescence was evaluated by NIF imaging. Implanted tumors underwent PDT and antitumor effects were analyzed after performing irradiation once or twice in ICG-lactosome groups. CONCLUSIONS: ICG-lactosomes accumulated in xenograft tumors and PDT had an antitumor effect on these malignant tumors. NIF imaging with ICG-lactosomes and PDT may be useful diagnostic and/or therapeutic agents for gallbladder cancer.

show abstract

“…O tratamento de dermatose em pacientes utilizando aminolevulinato de metilo e irradiação de luz vermelha com comprimento de onda de λ 630 nm demonstrou que a fotoquimioterapia é eficiente para o tratamento de pacientes com pequenos números de lesões 50 .…”

Section: Fotoquimioterapia Em Fungosunclassified

Princípios fundamentais dos lasers e suas aplicações

Pinheiro¹,

Almeida²,

Soares³

2017

Biotecnologia Aplicada À Agro&Indústria - Vol. 4

View full text Add to dashboard Cite

A luz, desde os primórdios da civilização, vem sendo utilizada com finalidades terapêuticas. O uso da helioterapia foi amplamente baseado em crenças religiosas e superstições. Os homens pré-históricos endeusaram o sol e consequentemente a luz solar, os quais foram considerados sagrados, sendo a eles atribuída a capacidade de afastar maus espíritos capazes de provocar doenças. Os deuses solares da Antiguidade eram considerados deuses da saúde e da cura.Devido à baixa qualidade dos relatos referentes ao emprego da helioterapia, sua eficácia é de difícil julgamento. Contudo, dados vindos das literaturas grega e romana mencionam que essa modalidade terapêutica foi utilizada largamente no tratamento da epilepsia, artrite, asma e obesidade. Nessas culturas, o banho de sol era tido como uma atividade saudável e um método de medicina preventiva, como reconhecido por Heródoto no século VI a.C.Simultaneamente à adoração das várias formas de agentes emissores de luz, esta foi utilizada pelos seres humanos de forma terapêutica e científica.

show abstract

Tumor-selective near-infrared photodynamic therapy with novel indocyanine green-loaded nanocarrier delays paralysis in rats with spinal metastasis

Cited by 11 publications

References 24 publications

Near-infrared fluorescence imaging and photodynamic therapy with indocyanine green lactosome has antineoplastic effects for hepatocellular carcinoma

Near-infrared fluorescence imaging and photodynamic therapy with indocyanine green lactosome has antineoplastic effects for hepatocellular carcinoma

Near-infrared fluorescence imaging and photodynamic therapy with indocyanine green lactosomes has antineoplastic effects for gallbladder cancer

Princípios fundamentais dos lasers e suas aplicações

Contact Info

Product

Resources

About