Tumor-specific expression detected with the use of an expression vector driven by human telomerase reverse transcriptase gene promoter

Yin, Jun; Fu, Panfeng; Wang, Xiaobo; Jin, Gang; Xiu, Ruijuan

doi:10.1016/j.lab.2004.09.010

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2010

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“…Especially, the promoter transcribing the telomerase reverse transcriptase (TERT) element of the enzyme complex has been in focus owing to its selective activity in cells with telomerase activity and hence in many cancer cell types 6–9 . Many in vitro and in vivo studies have already been conducted with this promoter for cancer‐specific gene therapy 6,7,10–14 …”

Section: Introductionmentioning

confidence: 99%

The human and canine TERT promoters function equivalently in human and canine cells

Arendt

Nasir

Morgan

2010

Veterinary and Comparative Oncology

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Telomerase targeted cancer gene therapy is being exploited for treatment of human cancer. The high incidence and many comparative aspects of human and canine cancer and the compliance and dedication of dog owners to treat cancer makes the canine pet population a good clinical model for investigating and developing new cancer therapeutics. Here, we report that the human telomerase promoter operates in canine cells, suggesting that human telomerase promoter-driven cancer therapy can be used to treat cancer in canines. Therefore, the canine pet population can act as a clinical model for new drug development based on telomerase therapeutics.

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Section: Introductionmentioning

confidence: 99%