Tumor-specific nitric oxide generator to amplify peroxynitrite based on highly penetrable nanoparticles for metastasis inhibition and enhanced cancer therapy

Shi, Menghao; Zhang, Jiulong; Wang, Yu; Chang, Peng; Hu, Haiyang; Qiao, Mingxi; Chen, Fan

doi:10.1016/j.biomaterials.2022.121448

Cited by 55 publications

(27 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, NO and ⋅O 2 − can react quickly to form reactive nitrogen species (RNS) peroxynitrite (ONOO − ), which is more cytotoxic than ROS. [45,46] As a result, the plasmonic CuPt@BNN (CPB) triggered closedloop NO gas, free radicals, and mild photothermal therapy achieves a highly effective reciprocally promoting antitumor outcome.…”

Section: Introductionmentioning

confidence: 99%

Dendritic Plasmonic CuPt Alloys for Closed‐Loop Multimode Cancer Therapy with Remarkably Enhanced Efficacy

Chang

Wang

Liu

et al. 2022

Small

View full text Add to dashboard Cite

instruments, laser diagnosis, laser surgery, and so on, motivate the advancement of biomedical domain. [2][3][4] Along with the rapid development of nanotechnology and nanomedicine, the interactions between nanomaterials and lasers led to the emergence of phototherapy. [5][6][7][8] In particular, plasmons that greatly restrict the optical energy into nanometric areas can remarkably strengthen light-matter interactions. [9,10] The localized surface plasmon resonances (LSPR) occur when light-excited electrons oscillate collectively in metallic plasmons, which induces two important effects: highly dense electron clouds near the particle's surface, and strong light absorption at the plasmon resonant frequency. [11,12] As a consequence, plasmonic metals can generate extraordinary photodynamic and photothermal properties. [13,14] Laser-activated plasmons, with spatiotemporal controllability nature, can realize site-targeted tumor phototherapy, effectively avoiding the system toxicity of traditional chemotherapy and radiotherapy. [15,16] With the deepening demands of the translation from basic scientific research to clinical applications, the practical scientific issues in nanomaterials-induced phototherapy, such as therapeutic efficacy and biosafety, have come into focus. [17] In plasmons involved photodynamic therapy (PDT), superoxide anion free radicals (•O 2 − ) are generated The outcome of laser-triggered plasmons-induced phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), is significantly limited by the hypoxic tumor microenvironment and the upregulation of heat shock proteins (HSPs) in response to heat stress. Mitochondria, the biological battery of cells, can serve as an important breakthrough to overcome these obstacles. Herein, dendritic triangular pyramidal plasmonic CuPt alloys loaded with heat-sensitive NO donor N, N′-di-sec-butyl-N, N′-dinitroso-1,4phenylenediamine (BNN) is developed. Under 808 nm laser irradiation, plasmonic CuPt can generate superoxide anion free radicals (•O 2 − ) and heat simultaneously. The heat generated can then trigger the release of NO gas, which not only enables gas therapy but also damages the mitochondrial respiratory chain. Impaired mitochondrial respiration leads to reduced oxygen consumption and insufficient intracellular ATP supply, which effectively alleviates tumor hypoxia and undermines the synthesis of HSPs, in turn boosting plasmonic CuPt-based PDT and mild PTT. Additionally, the generated NO and •O 2 − can react to form more cytotoxic peroxynitrite (ONOO − ). This work describes a plasmonic CuPt@BNN (CPB) triggered closed-loop NO gas, free radicals, and mild photothermal therapy strategy that is highly effective at reciprocally promoting antitumor outcomes.

show abstract

Section: Introductionmentioning

confidence: 99%

Dendritic Plasmonic CuPt Alloys for Closed‐Loop Multimode Cancer Therapy with Remarkably Enhanced Efficacy

Chang

Wang

Liu

et al. 2022

Small

View full text Add to dashboard Cite

show abstract

“…ONOO- can convert pro-MMPs into MMPs to degrade the extracellular matrix to enhance the penetration ability of nanoparticles and induce DNA impairment. NO and ONOO- can cause mitochondrial dysfunction by reducing mitochondrial membrane potential and inhibiting the generation of ATP, which effectively suppresses ATP-related tumor-derived vesicles and tumor metastasis [ 162 ]. Moreover, the derived RNS and superoxide can effectively kill cancer cells by inducing nitrosative or oxidative stress, DNA or mitochondrial impairment and improving inflammatory reactions, resulting in accelerated cell apoptosis [ 147 , 163 – 165 ].…”

Section: Stimuli-responsive Targeting Strategiesmentioning

confidence: 99%

Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

et al. 2022

View full text Add to dashboard Cite

Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one of the obstacles in cancer therapy. To help overcome this, nanoscale drug delivery systems have provided an alternative avenue for improving the therapeutic potential of various agents and bioactive molecules through the enhanced permeability and retention (EPR) effect. Nanosystems with cancer-targeted ligands can achieve effective delivery to the tumor cells utilizing cell surface-specific receptors, the tumor vasculature and antigens with high accuracy and affinity. Additionally, stimuli-responsive nanoplatforms have also been considered as a promising and effective targeting strategy against tumors, as these nanoplatforms maintain their stealth feature under normal conditions, but upon homing in on cancerous lesions or their microenvironment, are responsive and release their cargoes. In this review, we comprehensively summarize the field of active targeting drug delivery systems and a number of stimuli-responsive release studies in the context of emerging nanoplatform development, and also discuss how this knowledge can contribute to further improvements in clinical practice.

show abstract

“…Additionally, nitric oxide (NO), an exogenous regulating agent, aids in relieving tumor hypoxia by modulating angiogenesis. A few NO donors, including sodium nitroprusside, 383 S -nitrosothiols, 384 d -arginine, 117 l -arginine, 385 DETA NONOate, 386 and 3-morpholinosydnonimine hydrochloride, 387 have been successfully used to prepare NO-generating nanomedicines to alleviate tumor hypoxia. A NO-generating micelle was formed via self-assembly through thin-film hydration from d -α-Tocopheryl polyethylene glycol 1000 succinate (TPGS)-NO.…”

Section: State-of-the-art Nanomedicine-assisted Cancer Radio-immunoth...mentioning

confidence: 99%

Nanomedicine embraces cancer radio-immunotherapy: mechanism, design, recent advances, and clinical translation

Luo

Zhang

et al. 2023

Chem. Soc. Rev.

View full text Add to dashboard Cite

show abstract

Tumor-specific nitric oxide generator to amplify peroxynitrite based on highly penetrable nanoparticles for metastasis inhibition and enhanced cancer therapy

Cited by 55 publications

References 56 publications

Dendritic Plasmonic CuPt Alloys for Closed‐Loop Multimode Cancer Therapy with Remarkably Enhanced Efficacy

Dendritic Plasmonic CuPt Alloys for Closed‐Loop Multimode Cancer Therapy with Remarkably Enhanced Efficacy

Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

Nanomedicine embraces cancer radio-immunotherapy: mechanism, design, recent advances, and clinical translation

Contact Info

Product

Resources

About