Tumor stage, tumor site and HPV dependent correlation of perfusion CT parameters and [18F]-FDG uptake in head and neck squamous cell carcinoma

Nesteruk, Marta; Lang, Stephanie; Veit-Haibach, Patrick; Studer, Gabriela; Stieb, Sonja; Glatz, S.; Hemmatazad, Hossein; Ikenberg, Kristian; Huber, Gerhard; Pruschy, Martin; Gückenberger, Matthias; Klöck, Stephan

doi:10.1016/j.radonc.2015.09.026

Cited by 18 publications

(11 citation statements)

References 31 publications

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“…Moreover, other studies have shown that those standard PET measures correlate to tumor stage [18,21], whereas the predictions based on our PET radiomics model were independent of tumor stage (supplement Figure 2S). This demonstrates, on a clinically relevant dataset, that radiomics is an added value in comparison to standard PET measures in terms of local tumor control prediction.…”

Section: Discussionmentioning

confidence: 51%

Comparison of PET and CT radiomics for prediction of local tumor control in head and neck squamous cell carcinoma

et al. 2017

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(2017). Material and methodsData from HNSCC patients (n=121) treated with definitive radiochemotherapy were used for model training. In total, 569 radiomic features were extracted from both contrast enhanced CT and 18F-FDG PET images in the primary tumor region.CT, PET and combined PET/CT radiomic models to assess local tumor control were trained separately. Five feature selection and three classification methods were implemented. The performance of the models was quantified using concordance index (CI) in 5-fold cross-validation in the training cohort. The best models, per image modality, were compared and verified in the independent validation cohort (n=51). The difference in CI was investigated using bootstrapping. Additionally, the observed and radiomics-based estimated probabilities of local tumor control were compared between two risk groups. ResultsThe feature selection using principal component analysis and the classification based on the multivariabale Cox regression with backward selection of the variables resulted in the best models for all image modalities (CICT=0.72, CIPET=0.74, CIPET/CT=0.77). Tumors more homogenous in CT density (decreased GLSZMsize_zone_entropy) and with a focused region of high FDG uptake (higher GLSZMSZLGE) indicated better prognosis. No significant difference in the performance of the models in the validation cohort was observed (CICT=0.73, CIPET=0.71, CIPET/CT=0.73). However, the CT radiomics based model overestimated the probability of tumor control in the poor prognostic group (predicted=68%, observed=56%). ConclusionBoth CT and PET radiomics showed equally good discriminative power for local tumor control modeling in HNSCC. However, CT-based predictions overestimated the local control rate in the poor prognostic validation cohort and thus we recommend to base the local control modeling on the 18F-FDG PET.

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Section: Discussionmentioning

confidence: 51%

Comparison of PET and CT radiomics for prediction of local tumor control in head and neck squamous cell carcinoma

et al. 2017

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“…Presence of HPV is an important prognostic factor, which is reflected in the 8th edition of the American Joint Committee on Cancer (AJCC) TNM (Tumor Nodes Metastases classification) staging system [13,14]. There is a limited number of studies on the relationship between PET imaging and HPV status in HNSCC [3,[15][16][17]. Furthermore, very few studies concern the utility of PET/MRI in the characterization of HPV-related HNC [8,18].…”

Section: Introductionmentioning

confidence: 99%

Usefulness of Hybrid PET/MRI in Clinical Evaluation of Head and Neck Cancer Patients

Samołyk-Kogaczewska¹,

Sierko

Dziemiańczyk-Pakieła

et al. 2020

Cancers

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(1) Background: The novel hybrid of positron emission tomography/magnetic resonance (PET/MR) examination has been introduced to clinical practice. The aim of our study was to evaluate PET/MR usefulness in preoperative staging of head and neck cancer (HNC) patients (pts); (2) Methods: Thirty eight pts underwent both computed tomography (CT) and PET/MR examination, of whom 21 pts underwent surgical treatment as first-line therapy and were further included in the present study. Postsurgical tissue material was subjected to routine histopathological (HP) examination with additional evaluation of p16, human papillomavirus (HPV), Epstein-Barr virus (EBV) and Ki67 status. Agreement of clinical and pathological T staging, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) of CT and PET/MR in metastatic lymph nodes detection were defined. The verification of dependences between standardized uptake value (SUV value), tumor geometrical parameters, number of metastatic lymph nodes in PET/MR and CT, biochemical parameters, Ki67 index, p16, HPV and EBV status was made with statistical analysis of obtained results; (3) Results: PET/MR is characterized by better agreement in T staging, higher specificity, sensitivity, PPV and NPV of lymph nodes evaluation than CT imaging. Significant correlations were observed between SUVmax and maximal tumor diameter from PET/MR, between SUVmean and CT tumor volume, PET/MR tumor volume, maximal tumor diameter assessed in PET/MR. Other correlations were weak and insignificant; (4) Conclusions: Hybrid PET/MR imaging is useful in preoperative staging of HNC. Further studies are needed.

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“…Then the resolution and slice thickness of all CT scans was adjusted to the maximum slice thickness used (3 mm). Based on these CTs scans the three perfusion maps, blood volume (BV), blood flow (BF) and mean transit time (MTT) were calculated using an in-house developed software, which is based on the singular value decomposition method (15,16). All maps were normalized to the perfusion values inside the external iliac artery.…”

Section: Methodsmentioning

confidence: 99%

Exploratory Radiomics in Computed Tomography Perfusion of Prostate Cancer

Tanadini‐Lang

Bogowicz

Veit-Haibach

et al. 2018

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Tumor stage, tumor site and HPV dependent correlation of perfusion CT parameters and [18F]-FDG uptake in head and neck squamous cell carcinoma

Cited by 18 publications

References 31 publications

Comparison of PET and CT radiomics for prediction of local tumor control in head and neck squamous cell carcinoma

Comparison of PET and CT radiomics for prediction of local tumor control in head and neck squamous cell carcinoma

Usefulness of Hybrid PET/MRI in Clinical Evaluation of Head and Neck Cancer Patients

Exploratory Radiomics in Computed Tomography Perfusion of Prostate Cancer

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