Tumor-Suppression Mechanisms of Protein Tyrosine Phosphatase O and Clinical Applications

Kang, Man-Man; Shan, Shun-Lin; Wen, Xuyang; Husheng, Shan; Wang, Zhengjun

doi:10.7314/apjcp.2015.16.15.6215

Cited by 7 publications

(4 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reduced expression of this gene was also observed in B-cell chronic lymphocytic leukaemia (44). Moreover, the re-activation of PTPRO in tumour tissues can either contribute to tumour reduction or improve its susceptibility to chemotherapy (42,45). It is postulated that PTPRO regulates insulin and lipid metabolism via the PI3K/Akt/MDM4/MDM2/P53 pathway by influencing autophagy (46).…”

Section: Resultsmentioning

confidence: 99%

Expression Analysis of Tyrosine Phosphatase Genes at Different Stages of Renal Cell Carcinoma

2020

View full text Add to dashboard Cite

Background: Renal cell carcinoma (RCC) is a common urological cancer, and its risk correlates with environmental factors such as obesity, smoking and hypertension. Microarray technology enables analysis of the expression pattern of the whole phosphatome, members of which are involved in many cellular pathways and may act as either tumour suppressors or oncogenes in cancers. Materials and Methods: We analysed data for the expression level of 87 out of 107 known protein phosphatase genes included in the Hugo Gene Nomenclature Committee Website for 72 RCC tissues and paired healthy tissues obtained from the GEO Database. Results: Our analysis revealed overexpression of DUSP1, DUSP4, PTP4A3, PTPRC and PTPRE genes at all examined stages of RCC. Moreover, we found overexpression of PTPN12 at stage 2, overexpression of CDKN3 at stages 3 and 4, and overexpression of DUSP10 and PTPN22 at stages 2, 3 and 4. Lower expression of DUSP9, PTPR9 and PTPRO was also observed at all stages. Conclusion: Significant changes in expression patterns of protein tyrosine phosphatase genes confirm the involvement of this group in crucial carcinogenesis pathways underlying RCC. Thus, we postulate that protein tyrosine phosphatases play an important role in RCC promotion and progression, and may be considered as potential therapeutic targets.

show abstract

Section: Resultsmentioning

confidence: 99%

Expression Analysis of Tyrosine Phosphatase Genes at Different Stages of Renal Cell Carcinoma

2020

View full text Add to dashboard Cite

show abstract

“…The previous results of this study showed that the expression level of PTPRO was positively correlated with the prognosis of various solid tumor and was also closely related to the clinical characteristics [12,22]. Therefore, we further explored whether PTPRO could be used to assess the prognosis of LUAD.…”

Section: Construction Of a Nomogram Based On Ptpro Expression Levelsmentioning

confidence: 93%

Comprehensively Analyze the Prognosis Significance and Immune Implication of PTPRO in Lung Adenocarcinoma

Lin

Zhang

Liu³

et al. 2023

Mediators of Inflammation

View full text Add to dashboard Cite

Immunotherapy for lung adenocarcinoma (LUAD) is considered to be a promising treatment option, but only a minority of patients benefit from it. Therefore, it is essential to clarify the regulation mechanism of the tumor immune microenvironment (TIM) of the LUAD. Receptor-type protein tyrosine phosphatase (PTPRO) has been shown to be a tumor suppressor in a variety of tumor; however, its role in LUAD has never been reported. In this study, we first found that PTPRO was lowly expressed in LUAD and positively correlated with patient prognosis. Next, we investigated the relationship between PTPRO and clinical characteristics, and the results showed that gender, age, T, and stage were closely related to the expression level of PTPRO. Moreover, we performed univariate and multivariate analyses, and the results revealed that PTPRO was a protective factor for LUAD. By constructing a nomogram based on the expression level of PTPRO and various clinical characteristics, it was proved that the nomogram has a good predictive capacity. Furthermore, we analyzed the coexpression network of PTPRO through multiple databases and performed GO and KEGG enrichment analyses. The results demonstrated that PTPRO was involved in the regulation of multiple immune pathways. In addition, we analyzed whether PTPRO expression of LUAD regulate immune cell infiltration and the results demonstrated that PTPRO was closely related to the infiltration of various immune cells. Finally, we predicted LUAD sensitivity to chemotherapeutics and response to immunotherapy by PTPRO expression levels. The results showed that PTPRO expression level affect the sensitivity of various chemotherapeutic drugs and may be involved in the efficacy of immunotherapy. These results we obtained suggested that PTPRO is closely related to the prognosis and TIM of LUAD, which may be a potential immunotherapeutic target for LUAD.

show abstract

“…While numerous researchers focus on PTKs, which have dominated the cancer target therapeutics sphere. Increasing articles have reported that PTPs play a role in certain physiological and pathological activities by regulating tyrosine dephosphorylation, which is an opposing but equally significant mechanism as PTKs [3,4]. Protein tyrosine phosphatase receptor type O (PTPRO), one of the receptor-type PTPs (RPTPs), was first found in renal glomerular epithelial cells [5].…”

Section: Introductionmentioning

confidence: 99%

Protein tyrosine phosphatase PTPRO represses lung adenocarcinoma progression by inducing mitochondria-dependent apoptosis and restraining tumor metastasis

Dai,

Shi,

Liu

et al. 2024

Cell Death Dis

View full text Add to dashboard Cite

Emerging evidence indicates that protein activities regulated by receptor protein tyrosine phosphatases (RPTPs) are crucial for a variety of cellular processes, such as proliferation, apoptosis, and immunological response. Protein tyrosine phosphatase receptor type O (PTPRO), an RPTP, has been revealed as a putative suppressor in the development of particular tumors. However, the function and the underlying mechanisms of PTPRO in regulating of lung adenocarcinoma (LUAD) are not well understood. In this view, the present work investigated the role of PTPRO in LUAD. Analysis of 90 pairs of clinical LUAD specimens revealed significantly lower PTPRO levels in LUAD compared with adjacent non-tumor tissue, as well as a negative correlation of PTPRO expression with tumor size and TNM stage. Survival analyses demonstrated that PTPRO level can help stratify the prognosis of LUAD patients. Furthermore, PTPRO overexpression was found to suppress the progression of LUAD both in vitro and in vivo by inducing cell death via mitochondria-dependent apoptosis, downregulating protein expression of molecules (Bcl-2, Bax, caspase 3, cleaved-caspase 3/9, cleaved-PARP and Bid) essential in cell survival. Additionally, PTPRO decreased LUAD migration and invasion by regulating proteins involved in the epithelial-to-mesenchymal transition (E-cadherin, N-cadherin, and Snail). Moreover, PTPRO was shown to restrain JAK2/STAT3 signaling pathways. Expression of PTPRO was negatively correlated with p-JAK2, p-STAT3, Bcl-2, and Snail levels in LUAD tumor samples. Furthermore, the anti-tumor effect of PTPRO in LUAD was significant but compromised in STAT3-deficient cells. These data support the remarkable suppressive role of PTPRO in LUAD, which may represent a viable therapeutic target for LUAD patients.

show abstract

Tumor-Suppression Mechanisms of Protein Tyrosine Phosphatase O and Clinical Applications

Cited by 7 publications

References 82 publications

Expression Analysis of Tyrosine Phosphatase Genes at Different Stages of Renal Cell Carcinoma

Expression Analysis of Tyrosine Phosphatase Genes at Different Stages of Renal Cell Carcinoma

Comprehensively Analyze the Prognosis Significance and Immune Implication of PTPRO in Lung Adenocarcinoma

Protein tyrosine phosphatase PTPRO represses lung adenocarcinoma progression by inducing mitochondria-dependent apoptosis and restraining tumor metastasis

Contact Info

Product

Resources

About