Tumor Suppressor and Oncogenic Role of Long Non-Coding RNAs in Cancer

Güzel, Esra; Okyay, Tugba Muhlise; Yalcinkaya, Burhanettin; Karacaoglu, Seymanur; Gocmen, Melek; Akcakuyu, Muhammed Huseyin

doi:10.14744/nci.2019.46873

Cited by 63 publications

(60 citation statements)

References 49 publications

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“…Immunotherapy (briefly mentioned in this review) and modulation of the function of various non-coding RNAs are other forms of cancer therapies that we did not have time to address here [609][610][611][612][613][614].…”

Section: Discussionmentioning

confidence: 99%

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Secondary Resistant Mutations to Small Molecule Inhibitors in Cancer Cells

Hamid

Petreaca

2020

Cancers

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Secondary resistant mutations in cancer cells arise in response to certain small molecule inhibitors. These mutations inevitably cause recurrence and often progression to a more aggressive form. Resistant mutations may manifest in various forms. For example, some mutations decrease or abrogate the affinity of the drug for the protein. Others restore the function of the enzyme even in the presence of the inhibitor. In some cases, resistance is acquired through activation of a parallel pathway which bypasses the function of the drug targeted pathway. The Catalogue of Somatic Mutations in Cancer (COSMIC) produced a compendium of resistant mutations to small molecule inhibitors reported in the literature. Here, we build on these data and provide a comprehensive review of resistant mutations in cancers. We also discuss mechanistic parallels of resistance.

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Section: Discussionmentioning

confidence: 99%

“…The immune system function in slowing tumor progression has been well documented [615,616]. Non-coding RNAs have a plethora of functions in the cell including regulation of gene expression and protein localization [611]. Non-coding RNAs also regulate gene expression in the immune cells allowing tumors to evade the immune system [617].…”

Section: Discussionmentioning

confidence: 99%

Secondary Resistant Mutations to Small Molecule Inhibitors in Cancer Cells

Hamid

Petreaca

2020

Cancers

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“…Long non-coding RNAs (lncRNAs) are a type of RNA with a length exceeding 200 nucleotides and without protein coding potential [ 5 , 83 , 84 , 85 ]. Modifications of the epigenetic sphere include the regulation of imprinting, conformational changes at the chromosomal level and chromatin remodeling, modifications in the methylation of histone proteins and DNA, and regulation through ncRNAs [ 86 , 87 ].…”

Section: Long Non-coding Rnas In Ummentioning

confidence: 99%

The Role of Non-Coding RNAs in Uveal Melanoma

Bande

Fernandez-Diaz

Fernandez-Marta

et al. 2020

Cancers

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Uveal melanoma (UM) is the most common primary intraocular tumor in adulthood. Approximately 50% of patients develop metastatic disease, which typically affects the liver and is usually fatal within one year. This type of cancer is heterogeneous in nature and is divided into two broad groups of tumors according to their susceptibility to develop metastasis. In the last decade, chromosomal abnormalities and the aberrant expression of several signaling pathways and oncogenes in uveal melanomas have been described. Recently, importance has been given to the association of the mentioned deregulation with the expression of non-coding RNAs (ncRNAs). Here, we review the different classes of ncRNAs—such as long non-coding RNAs (lncRNAs) and microRNAs (miRNAs)—and their contribution to the development of UM. Special attention is given to miRNAs and their regulatory role in physiopathology and their potential as biomarkers. As important agents in gene regulation, ncRNAs have a huge potential for opening up therapeutic pathways, predicting response to treatment, and anticipating patient outcome for UM.

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“…It has many different risk factors including hereditary, exposure to chemical agents, such as aflatoxin B1, smoking, and chronic alcohol abuse [3]. miRNAs are single stranded comprised of ~20 long, small non coding post transcriptional regulator RNAs and have important role cancer progression [4].…”

Section: Introductionmentioning

confidence: 99%

Role of mir-33a, mir-203b, mir361-3p, and mir-424 in hepatocellular carcinoma

et al. 2021

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Background/Aim: Hepatocellular carcinoma (HCC) is one of the most aggressive cancer. MicroRNAs (miRNAs), are small noncoding regulatory RNAs, that function post-transcriptionally. MiRNA deregulation was observed in the development and progression of HCC. In this study we aimed to investigate the expression levels of four miRNA (mir-33a, mir-203b, mir361-3p and mir-424) in HCC patients in comparison to healthy individuals. Materials and methods: Venous blood samples were collected from both HCC patients and healthy individuals. In order to determine relative expression levels of mir-33a, mir-203b, mir361-3p and hsa-mir-424 in HCC patients using probe-based Quantitative Real Time PCR (qRT-PCR) is performed. The cycle threshold (Ct) results were analyzed according to the 2 −∆∆Ct method and statistical analyses was performed by IBM SPSS Statistics for Windows, version 15. Results: qRT-PCR analysis revealed that the expression level of mir-33a (fold change: 7.3 and p<0,001), mir-203b (fold change: 4.6 and p<0,001), mir361-3p (fold change: 5.1 and p<0,001) were down regulated compared to healthy individuals and mir-424 did not show any significant change between the HCC patients and controls. Conclusion: Our results indicated that mir-33a, mir-203b and mir-361-3p, may significantly contribute to tumor pathogenesis in HCC and would have potential to be used as a non-invasive biomarker for cancer therapy.

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Tumor Suppressor and Oncogenic Role of Long Non-Coding RNAs in Cancer

Cited by 63 publications

References 49 publications

Secondary Resistant Mutations to Small Molecule Inhibitors in Cancer Cells

Secondary Resistant Mutations to Small Molecule Inhibitors in Cancer Cells

The Role of Non-Coding RNAs in Uveal Melanoma

Role of mir-33a, mir-203b, mir361-3p, and mir-424 in hepatocellular carcinoma

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