Tumor-suppressor miRNA-27b-5p regulates the growth and metastatic behaviors of ovarian carcinoma cells by targeting CXCL1

Abstract

MicroRNAs (miRNAs) play crucial functions in the progression of ovarian cancer. MiR-27b has been identified as cancer-associated miRNA. Nevertheless, the expression profile of microRNA-27b-5p (miR-27b-5p) and its functions in ovarian cancer are unexplored. Here, we demonstrated that miR-27b-5p was downregulated in ovarian carcinoma cells and clinical specimens. Higher expression of miR-27b-5p was allied to an unfavorable overall survival in ovarian cancer patient. Upregulation of miR-27b-5p decreased the viability, migration ability and invasion capacity of SKOV3 and A2780 cell. MiR-27b-5p also inhibited the growth of SKOV3 cell in nude mice. Additionally, we verified that C-X-C motif chemokine ligand 1 (CXCL1) was a target of miR-27b-5p in ovarian carcinoma cell. Restoring the expression of CXCL1 abolished the inhibitory impacts of miR-27b-5p in ovarian cancer carcinoma cell. This research revealed that miR-27b-5p restrained the progression of ovarian carcinoma possibly via targeting CXCL1.