Tumor-targeted and multi-stimuli responsive drug delivery system for near-infrared light induced chemo-phototherapy and photoacoustic tomography

Feng, Qianhua; Zhang, Yuanyuan; Zhang, Wanxia; Shan, Xiaoning; Yuan, Yujie; Zhang, Hongling; Hou, Lin; Zhang, Zhenzhong

doi:10.1016/j.actbio.2016.04.024

Cited by 159 publications

(80 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In contrast, for PTT to generate a high temperature in tissues, the photo-absorbing nanoparticles must be present, and thus, the effect more accurately damages the targeted legions 3, 4 . Several nanomaterials with excellent NIR light absorption properties have been developed as PTT agents, including gold nanomaterials 5–12 , copper nanomaterials 13–18 , carbon nanomaterials 19–23 , and NIR dyes 24–27 . However, the potential toxicity of non-degradable or slowly degradable nanoparticles (NPs), especially carbon nanotubes or gold nanoparticles, will inevitably limit their clinic applications 28–30 .…”

Section: Introductionmentioning

confidence: 99%

Near-infrared induced phase-shifted ICG/Fe3O4 loaded PLGA nanoparticles for photothermal tumor ablation

Niu

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Near-infrared (NIR) laser-induced photothermal therapy (PTT) uses a photothermal agent to convert optical energy into thermal energy and has great potential as an effective local, minimally invasive treatment modality for killing cancer cells. To improve the efficacy of PTT, we developed poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) encapsulating superparamagnetic iron oxide (Fe3O4), indocyanine green (ICG), and perfluoropentane (PFP) as synergistic agents for NIR laser-induced PTT. We fabricated a novel type of phase-shifting fluorescent magnetic NPs, Fe3O4/ICG@PLGA/PFP NPs, that effectively produce heat in response to NIR laser irradiation for an enhanced thermal ablation effect and a phase-shift thermoelastic expansion effect, and thus, can be used as a photothermal agent. After in vitro treatment of MCF-7 breast cancer cells with Fe3O4/ICG@PLGA/PFP NPs and NIR laser irradiation, histology and electron microscopy confirmed severe damage to the cells and the formation of many microbubbles with iron particles at the edge or outside of the microbubbles. In vivo experiments in mice with MCF-7 tumors demonstrated that Fe3O4/ICG@PLGA/PFP NPs could achieve tumor ablation upon NIR laser irradiation with minimal toxicity to non-irradiated tissues. Together, our results indicate that Fe3O4/ICG@PLGA/PFP NPs can be used as effective nanotheranostic agents for tumor ablation.

show abstract

Section: Introductionmentioning

confidence: 99%

Near-infrared induced phase-shifted ICG/Fe3O4 loaded PLGA nanoparticles for photothermal tumor ablation

Niu

et al. 2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…The Optical imaging (OI) technology (sometimes referred to as biophotonics), the inclusive term often used for different types of infrared, ultraviolet, and visible light, as well as sometimes also photoacoustic (see above) applications in biomedical imaging, have a number of interesting publications regarding NP applications for both PCa and BC [319,392,393,394,395,396,397,398,399,400]. Generally, a NP-based OI approach could enable or optimize an optical excitation energy in, for example, tumor tissue, enable multispectral imaging by combining spectroscopy and OI, or make possible multiplex imaging by using different color emitters for different targets simultaneously [300].…”

Section: Multimodal Imaging Options For Prostate and Breast Cancermentioning

confidence: 99%

“…For cancer applications, Ahir et al recently developed a copper oxide-nanowire NP decorated with folic acid and studied its effect on triple negative BC (TNBC). They found that their NPs induced apoptosis and retarded migration of the TNBC cells, and used optical fluorescence imaging to monitor its distribution in tumors and different organs [392]. Regarding PCa, Behnam et al constructed and investigated a PSMA-targeted bionized nanoferrite (BNF) NP in an experimental PCa model [319].…”

Section: Multimodal Imaging Options For Prostate and Breast Cancermentioning

confidence: 99%

Nanoparticles as Theranostic Vehicles in Experimental and Clinical Applications—Focus on Prostate and Breast Cancer

Elgqvist

2017

IJMS

View full text Add to dashboard Cite

Prostate and breast cancer are the second most and most commonly diagnosed cancer in men and women worldwide, respectively. The American Cancer Society estimates that during 2016 in the USA around 430,000 individuals were diagnosed with one of these two types of cancers, and approximately 15% of them will die from the disease. In Europe, the rate of incidences and deaths are similar to those in the USA. Several different more or less successful diagnostic and therapeutic approaches have been developed and evaluated in order to tackle this issue and thereby decrease the death rates. By using nanoparticles as vehicles carrying both diagnostic and therapeutic molecular entities, individualized targeted theranostic nanomedicine has emerged as a promising option to increase the sensitivity and the specificity during diagnosis, as well as the likelihood of survival or prolonged survival after therapy. This article presents and discusses important and promising different kinds of nanoparticles, as well as imaging and therapy options, suitable for theranostic applications. The presentation of different nanoparticles and theranostic applications is quite general, but there is a special focus on prostate cancer. Some references and aspects regarding breast cancer are however also presented and discussed. Finally, the prostate cancer case is presented in more detail regarding diagnosis, staging, recurrence, metastases, and treatment options available today, followed by possible ways to move forward applying theranostics for both prostate and breast cancer based on promising experiments performed until today.

show abstract

“…Ultrasound irradiation has not been controlled in intensity so as to produce tunable release profiles, but the use of on/off modulation of the field to control dosing was noted in the literature: for example, the release of rhodamine B from polystyrene-PDMS block co-polymeric nanofibers would be halted without the field and induced at a constant rate when the field is switched on[38]. Similar on/off modulations of photothermal, continuous-wave near-infrared laser irradiation allowed a precise control of the amount of released doxorubicin from mesoporous copper sulfide nanoparticles capped with hyaluronic acid to be achieved[39]. …”

Section: Introductionmentioning

confidence: 99%

Carriers for the tunable release of therapeutics: etymological classification and examples

Uskoković

Ghosh

2016

Expert Opinion on Drug Delivery

View full text Add to dashboard Cite

Introduction Physiological processes at the molecular level take place at precise spatiotemporal scales, which vary from tissue to tissue and from one patient to another, implying the need for the carriers that enable tunable release of therapeutics. Areas Covered Classification of all drug release to intrinsic and extrinsic is proposed, followed by the etymological clarification of the term “tunable” and its distinction from the term “tailorable”. Tunability is defined as analogous to tuning a guitar string or a radio receiver to the right frequency using a single knob. It implies changing a structural parameter along a continuous quantitative scale and correlating it numerically with the release kinetics. Examples of tunable, tailorable and environmentally responsive carriers are given, along with the parameters used to achieve these levels of control. Expert Opinion Interdependence of multiple variables defining the carrier microstructure obstructs the attempts to elucidate parameters that allow for the independent tuning of release kinetics. Learning from the tunability of nanostructured materials and superstructured metamaterials can be a fruitful source of inspiration in the quest for the new generation of tunable release carriers. The greater intersection of traditional materials sciences and pharmacokinetic perspectives could foster the development of more sophisticated mechanisms for tunable release.

show abstract

Tumor-targeted and multi-stimuli responsive drug delivery system for near-infrared light induced chemo-phototherapy and photoacoustic tomography

Cited by 159 publications

References 40 publications

Near-infrared induced phase-shifted ICG/Fe3O4 loaded PLGA nanoparticles for photothermal tumor ablation

Near-infrared induced phase-shifted ICG/Fe3O4 loaded PLGA nanoparticles for photothermal tumor ablation

Nanoparticles as Theranostic Vehicles in Experimental and Clinical Applications—Focus on Prostate and Breast Cancer

Carriers for the tunable release of therapeutics: etymological classification and examples

Contact Info

Product

Resources

About