Tumor targeted, stealthy and degradable bismuth nanoparticles for enhanced X-ray radiation therapy of breast cancer

Deng, Junjie; Xu, Shaojian; Hu, Weike; Xun, Xiaojie; Zheng, Liyuan; Su, Ming

doi:10.1016/j.biomaterials.2017.10.048

Cited by 183 publications

(125 citation statements)

References 60 publications

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“…10b1, longer retention time in blood circulation was detected for the RBC membrane-coated BiNPs (RBC-BiNPs) in comparison to their bare counterparts, mainly due to the reduced NP uptake by macrophages. 229 In this study, folate modified RBC (F-RBC)coated BiNPs showed a similar blood circulation trend as the ones camouflaged just using RBC membrane, demonstrating the negligible effect of folate on the circulation time. Compared to the bare NPs, prolonged circulation of RBC-BiNPs resulted in improved tumor accumulation via passive targeting 24 h postinjection.…”

Section: Biosafety and Biodistribution Of Binpssupporting

confidence: 55%

“…53,258 In general, BiNPs with any hydrodynamic size larger than the FST, various shapes, different surface coating and chemical composition have shown dominant accumulation in the liver shortly after intravenous injection. 229,232,245 However, the synthesis of very small particles, surface coated with proteinadsorption-resistant materials or using rapidly degradable BiNPs might help to alter the clearance pathway towards the urinary system. 237,245,250,259 For example, Bi was easily detectable in kidneys 2 h after the injection of dextran coated Bi-iron oxide nanohybrid.…”

Section: Biosafety and Biodistribution Of Binpsmentioning

confidence: 99%

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The versatile biomedical applications of bismuth-based nanoparticles and composites: therapeutic, diagnostic, biosensing, and regenerative properties

et al. 2020

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Studies of nanosized forms of bismuth (Bi)-containing materials have recently expanded from optical, chemical, electronic, and engineering fields towards biomedicine, as a result of their safety, cost-effective fabrication processes, large surface area, high stability, and high versatility in terms of shape, size, and porosity. Bi, as a nontoxic and inexpensive diamagnetic heavy metal, has been used for the fabrication of various nanoparticles (NPs) with unique structural, physicochemical, and compositional features to combine various properties, such as a favourably high X-ray attenuation coefficient and near-infrared (NIR) absorbance, excellent light-to-heat conversion efficiency, and a long circulation half-life. These features have rendered bismuth-containing nanoparticles (BiNPs) with desirable performance for combined cancer therapy, photothermal and radiation therapy (RT), multimodal imaging, theranostics, drug delivery, biosensing, and tissue engineering. Bismuth oxyhalides (BiO x , where X is Cl, Br or I) and bismuth chalcogenides, including bismuth oxide, bismuth sulfide, bismuth selenide, and bismuth telluride, have been heavily investigated for therapeutic purposes. The pharmacokinetics of these BiNPs can be easily improved via the facile modification of their surfaces with biocompatible polymers and proteins, resulting in enhanced colloidal stability, extended blood circulation, and reduced toxicity. Desirable antibacterial effects, bone regeneration potential, and tumor growth suppression under NIR laser radiation are the main biomedical research areas involving BiNPs that have opened up a new paradigm for their future clinical translation. This review emphasizes the synthesis and state-of-the-art progress related to the biomedical applications of BiNPs with different structures, sizes, and compositions. Furthermore, a comprehensive discussion focusing on challenges and future opportunities is presented.

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Section: Biosafety and Biodistribution Of Binpssupporting

confidence: 55%

Section: Biosafety and Biodistribution Of Binpsmentioning

confidence: 99%

The versatile biomedical applications of bismuth-based nanoparticles and composites: therapeutic, diagnostic, biosensing, and regenerative properties

et al. 2020

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“…Bi‐based nanomaterials, such as Bi 2 S 3 , Bi 2 Se 3 and Bi 2 O 3 , are another hot materials in radiosensitization . For example, Yao et al provided the first example of both in vitro and in vivo to demonstrate the radiosensitive effect of Bi 2 S 3 /poly(lactic‐ co ‐glycolic acid) (PLGA) nanocapsule against prostate cancer .…”

Section: General Strategies Of Nanomaterial‐mediated Tumor Radiosensimentioning

confidence: 99%

Emerging Strategies of Nanomaterial‐Mediated Tumor Radiosensitization

et al. 2018

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Nano-radiosensitization has been a hot concept for the past ten years, and the nanomaterial-mediated tumor radiosensitization method is mainly focused on increasing intracellular radiation deposition by high atomic number (high Z) nanomaterials, particularly gold (Au)-mediated radiation enhancement. Recently, various new nanomaterial-mediated radiosensitive approaches have been successively reported, such as catalyzing reactive oxygen species (ROS) generation, consuming intracellular reduced glutathione (GSH), overcoming tumor hypoxia, and various synergistic radiotherapy ways. These strategies may open a new avenue for enhancing the radiotherapeutic effect and avoiding its side effects. Nevertheless, reviews systematically summarizing these newly emerging methods and their radiosensitive mechanisms are still rare. Therefore, the general strategies of nanomaterial-mediated tumor radiosensitization are comprehensively summarized, particularly aiming at introducing the emerging radiosensitive methods. The strategies are divided into three general parts. First, methods on account of the intrinsic radiosensitive properties of nanoradiosensitizers for radiosensitization are highlighted. Then, newly developed synergistic strategies based on multifunctional nanomaterials for enhancing radiotherapy efficacy are emphasized. Third, nanomaterial-mediated radioprotection approaches for increasing the radiotherapeutic ratio are discussed. Importantly, the clinical translation of nanomaterial-mediated tumor radiosensitization is also covered. Finally, further challenges and outlooks in this field are discussed.

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“…Within 12 h, the efficient accumulation of Bi 2 Se 3 ‐chitosan (CS) NPs [ 35 ] targeted with an arginylglycylaspartic acid (RGD) active peptide in HeLa tumor cells was higher than those of Etc1/E6E7 normal cells, with a magnitude of 2.8 (Figure 3e). The longer circulation of red blood cell membrane (RBC)‐modified Bi NPs [ 36 ] persuaded a richer tumor uptake through passive targeting, as confirmed by the higher tumor uptake of RBC‐Bi NPs (4.53%ID g −1 ) compared to Bi NPs (2.29%ID g −1 ). In contrast, the conjugation of a tumor‐specific targeting folate ligand could further improve the accumulation of Bi NPs within 4T1‐tumors (7.59%ID g −1 ), inducing a 1.7 and 3.3 times increase over RBC‐Bi NPs and Bi NPs, respectively (Figure 3f).…”

Section: Passive Tumor Targeting Via the Epr Effectmentioning

confidence: 99%

Bismuth‐Based Nanomaterials: Recent Advances in Tumor Targeting and Synergistic Cancer Therapy Techniques

Badrigilan

Choupani

Khanbabaei

et al. 2020

Adv Healthcare Materials

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Despite all of the efforts in the field of cancer therapy, the heterogeneous properties of tumor cells induce an insufficient therapeutic outcome when treated with conventional monotherapies, necessitating a shift in cancer treatment from monotherapy to combination therapy for complete cancer treatment. Multifunctional bismuth (Bi)‐based nanomaterials (NMs) with therapeutic functions hold great promise for the fields of cancer diagnosis and therapy based on their low toxicity, X‐ray sensitive capabilities, high atomic number, near‐infrared driven semiconductor properties, and low cost. Herein, a comprehensive review of recent advances in various medicinal aspects of Bi‐based NMs is presented including: evaluation of in‐tumor site accumulation, tumor targeting, and therapeutic performance, as well as the characteristics, benefits, and shortcomings of Bi‐based NM‐mediated major monotherapies. In addition, the cooperative enhancement mechanisms between two or more of these monotherapies are described in detail to address common challenges in cancer therapy, such as multidrug resistance, hypoxia, and metastasis. Finally, this review opens new insights into the design of multimodal synergistic therapies for potential future clinical applications of Bi‐based NMs.

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Tumor targeted, stealthy and degradable bismuth nanoparticles for enhanced X-ray radiation therapy of breast cancer

Cited by 183 publications

References 60 publications

The versatile biomedical applications of bismuth-based nanoparticles and composites: therapeutic, diagnostic, biosensing, and regenerative properties

The versatile biomedical applications of bismuth-based nanoparticles and composites: therapeutic, diagnostic, biosensing, and regenerative properties

Emerging Strategies of Nanomaterial‐Mediated Tumor Radiosensitization

Bismuth‐Based Nanomaterials: Recent Advances in Tumor Targeting and Synergistic Cancer Therapy Techniques

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