Tumor targeting and MR imaging with lipophilic cyanine-mediated near-infrared responsive porous Gd silicate nanoparticles

Yeh, Chen Sheng; Su, Chia‐Hao; Ho, Wen Yueh; Huang, Chih Chia; Chang, Jui Cheng; Chien, Yi Hsin; Hung, Shu Ting; Liau, Min Chiau; Ho, H.P.

doi:10.1016/j.biomaterials.2013.04.020

Cited by 49 publications

(27 citation statements)

References 36 publications

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“…The silica coating on the surface of the NPs is done via co-condensation of TEOS and APTES. Silica coating on NPs meliorate the encapsulation of the dye and being optically transparent, it allows light to pass through it and facilitate optical imaging by the particles [29]. Also, it imparts biocompatibility to the particles.…”

Section: Resultsmentioning

confidence: 99%

FITC-Dextran entrapped and silica coated gadolinium oxide nanoparticles for synchronous optical and magnetic resonance imaging applications

Kumar

Meena

Hazari

et al. 2016

International Journal of Pharmaceutics

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Section: Resultsmentioning

confidence: 99%

FITC-Dextran entrapped and silica coated gadolinium oxide nanoparticles for synchronous optical and magnetic resonance imaging applications

Kumar

Meena

Hazari

et al. 2016

International Journal of Pharmaceutics

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“…The bridging atoms between the two aromatic heterocycles serve as a part of rigid cyclic ring which allows conformational stability and enhanced excitations/emission properties. The nitrogen atom in heterocyclic rings is amenable for modification to a variety of functional groups including negatively-charged carboxylic acid, sulfonic acid as well as uncharged alcohol, amine and ester, which can be used for manipulating physical properties of NIRF dyes such as water solubility and conjugation with other molecular entities [44, 45]. We found that the charged dyes were well retained in cancer cells with intact imaging capability by observing fluorescence signals, while the uncharged dyes were shown to be inactive with poor retention in cells.…”

Section: Discussionmentioning

confidence: 99%

Near-infrared fluorescence imaging of cancer mediated by tumor hypoxia and HIF1α/OATPs signaling axis

Shao

et al. 2014

Biomaterials

126

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Near-infrared fluorescence (NIRF) imaging agents are promising tools for noninvasive cancer imaging. Here, we explored the mechanistic properties of a specific group of NIR heptamethine carbocyanines including MHI-148 dye we identified and synthesized, and demonstrated these dyes to achieve cancer-specific imaging and targeting via a hypoxia-mediated mechanism. We found that cancer cells and tumor xenografts exhibited hypoxia-dependent MHI-148 dye uptake in vitro and in vivo, which was directly mediated by hypoxia-inducible factor 1α (HIF1α). Microarray analysis and dye uptake assay further revealed a group of hypoxia-inducible organic anion-transporting polypeptides (OATPs) responsible for dye uptake, and the correlation between OATPs and HIF1α was manifested in progressive clinical cancer specimens. Finally, we demonstrated increased uptake of MHI-148 dye in situ in perfused clinical tumor samples with activated HIF1α/OATPs signaling. Our results establish these NIRF dyes as potential tumor hypoxia-dependent cancer-targeting agents and provide a mechanistic rationale for continued development of NIRF imaging agents for improved cancer detection, prognosis and therapy.

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“…The combinatory application of NIRF imaging and other imaging modalities that can delineate anatomical structures extends fluorometric determination of biomedical information. Various multimodal imaging schemes are designed for facile combination between NIRF probes and traditional imaging approaches that offer in vivo tumor images with excellent spatial resolution, such as MRI, 16,[83][84][85][86] CT, PETS, 87 single photon emission computed tomography (SPECT), 88 PAI, 89 Raman imaging, 90,91 etc. The main multimodal strategies are superparamagnetic iron oxide and gadolinium MR contrast conjugated with NIRF dyes or NPs.…”

Section: Multimodal Nirf Probesmentioning

confidence: 99%

Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field

Yi¹,

Wang²,

Qin³

et al. 2014

IJN

215

149

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Near-infrared fluorescence (NIRF) imaging is an attractive modality for early cancer detection with high sensitivity and multi-detection capability. Due to convenient modification by conjugating with moieties of interests, NIRF probes are ideal candidates for cancer targeted imaging. Additionally, the combinatory application of NIRF imaging and other imaging modalities that can delineate anatomical structures extends fluorometric determination of biomedical information. Moreover, nanoparticles loaded with NIRF dyes and anticancer agents contribute to the synergistic management of cancer, which integrates the advantage of imaging and therapeutic functions to achieve the ultimate goal of simultaneous diagnosis and treatment. Appropriate probe design with targeting moieties can retain the original properties of NIRF and pharmacokinetics. In recent years, great efforts have been made to develop new NIRF probes with better photostability and strong fluorescence emission, leading to the discovery of numerous novel NIRF probes with fine photophysical properties. Some of these probes exhibit tumoricidal activities upon light radiation, which holds great promise in photothermal therapy, photodynamic therapy, and photoimmunotherapy. This review aims to provide a timely and concise update on emerging NIRF dyes and multifunctional agents. Their potential uses as agents for cancer specific imaging, lymph node mapping, and therapeutics are included. Recent advances of NIRF dyes in clinical use are also summarized.

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Tumor targeting and MR imaging with lipophilic cyanine-mediated near-infrared responsive porous Gd silicate nanoparticles

Cited by 49 publications

References 36 publications

FITC-Dextran entrapped and silica coated gadolinium oxide nanoparticles for synchronous optical and magnetic resonance imaging applications

FITC-Dextran entrapped and silica coated gadolinium oxide nanoparticles for synchronous optical and magnetic resonance imaging applications

Near-infrared fluorescence imaging of cancer mediated by tumor hypoxia and HIF1α/OATPs signaling axis

Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field

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