2023
DOI: 10.1007/s12195-022-00757-5
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Tumor-Targeting Extracellular Vesicles Loaded with siS100A4 for Suppressing Postoperative Breast Cancer Metastasis

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Cited by 8 publications
(3 citation statements)
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“…There are various reasons, for instance, due to their short half-life, immunogenicity, failure to pass the blood-brain barrier, off-target effects and so on (Castanotto & Rossi, 2009 ; Ciccone et al., 2023 ). To improve targeting ability and good biocompatibility, EVs from breast cancer cells were used to load sis100A4 (Zhao et al., 2020 ; Pan et al., 2023 ). A further investigation by Alvarez-Erviti et al.…”
Section: Extracellular Vesicles As Vehicles For Targeted Drug Deliverymentioning
confidence: 99%
“…There are various reasons, for instance, due to their short half-life, immunogenicity, failure to pass the blood-brain barrier, off-target effects and so on (Castanotto & Rossi, 2009 ; Ciccone et al., 2023 ). To improve targeting ability and good biocompatibility, EVs from breast cancer cells were used to load sis100A4 (Zhao et al., 2020 ; Pan et al., 2023 ). A further investigation by Alvarez-Erviti et al.…”
Section: Extracellular Vesicles As Vehicles For Targeted Drug Deliverymentioning
confidence: 99%
“…Modified sEVs exhibited significantly greater cellular uptake, gene silencing, and treatment efficacy, which ultimately translated into a notable increase in the survival rate of the animals as compared to unmodified EVs. 90 In addition to specific targeting ligands, lipid engineering of exosomes using amphiphilic phosphatidylcholine (PC) molecules was also a simple and effective strategy to enhance tumor cell internalization of drug/RNA. 91 Studies have shown that exosomes modified with PC have a 2-fold increase in internalization and uptake rate by tumor cells compared to native exosomes.…”
Section: Small Ev Engineering and Hybridsmentioning
confidence: 99%
“…Moreover, in a postoperative breast cancer metastasis mice model, the incorporation of iRGD cyclic peptide (amino acid sequence CRGDKGPDC) into sEVs led to enhanced targeting efficiency of siS100A4. Modified sEVs exhibited significantly greater cellular uptake, gene silencing, and treatment efficacy, which ultimately translated into a notable increase in the survival rate of the animals as compared to unmodified EVs . In addition to specific targeting ligands, lipid engineering of exosomes using amphiphilic phosphatidylcholine (PC) molecules was also a simple and effective strategy to enhance tumor cell internalization of drug/RNA .…”
Section: Small Ev Engineering and Hybridsmentioning
confidence: 99%