Tumor Thrombus of Thyroid Malignancies in Veins: Importance of Detection by Ultrasonography

Kobayashi, Kaoru; Hirokawa, Mitsuyoshi; Yabuta, Tetsuro; Fukushima, Mitsuhiro; Kihara, Minoru; Higashiyama, Takuya; Tomoda, Chisato; Takamura, Yuuki; Ito, Yasuhiro; Miya, Akihiro; Amino, Nobuyuki; Miyauchi, Akira

doi:10.1089/thy.2010.0099

Cited by 37 publications

(44 citation statements)

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“…High frequency probes (usually 7 -14 MHz) are routinely used for observing thyroid lesions, but it is difficult and they are not suitable for observing deep lesions from the skin. This is the same situation when attempting to detect tumor thrombi of thyroid malignancies by preoperative ultrasonography [4].…”

Section: Discussionmentioning

confidence: 86%

“…We previously reported a few cases of widely invasive type of follicular carcinoma with tumor thrombus detected by preoperative ultrasonography in combination with cytological findings of "follicular neoplasm". A solid mass in the lumen of veins, that is a tumor thrombus, may be a large form of vascular invasion of widely invasive type of follicular carcinoma [4].…”

Section: Discussionmentioning

confidence: 99%

“…Ultrasonography Preoperative ultrasound examination was performed by well-trained, registered ultrasonographers, using a TOSHIBA Aplio SSA-770A ultrasound system with PLT-1204AX (7 -14 MHz) and PLT-805AT (5 -12 MHz) linear probes. In order to make ultrasonic diagnosis of thyroid tumors, our USC system was used (=Ultrasound Class for thyroid tumors at our hospital) [4,5]. All the thyroid tumors were classified into USC 1-5 at ultrasonic diagnosis.…”

Section: Patientsmentioning

confidence: 99%

“…The widely invasive type of follicular carcinoma has a high propensity to invade adjacent thyroid tissue and/ or blood vessels at the macroscopic and microscopic specimens [2,3]. We previously described the ultrasonographic features of tumor thrombi showing direct invasion to the veins as a macroscopic or large form of vascular invasion of follicular carcinoma [4]. A macroscopic form of capsular invasion might be detected as a solid mass protruding from the capsule of the main tumor by preoperative ultrasonography in a few patients with the widely invasive type of follicular carcinoma.…”

Section: Introductionmentioning

confidence: 99%

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Tumor protrusion with intensive blood signals on ultrasonography is a strongly suggestive finding of follicular thyroid carcinoma.

et al. 2016

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Aim: It is difficult to differentiate follicular carcinomas (FC) from follicular adenomas (FA) because ultrasonography and cytology provide very similar findings. FC is histopathologically diagnosed to have capsular and/or vascular invasion. In a few patients, tumor protrusions are observed by preoperative ultrasonography as large forms of capsular invasion of follicular carcinomas. The aim of the study was to clarify the predictive value of tumor protrusions on preoperative ultrasonography for follicular carcinomas. Material and methods: A total of 531 patients (FC: 184 patients, FA: 347 patients) undergoing thyroid surgery were included in this study. A tumor protrusion on ultrasonography was defined as follows: 1) a solid tumor extending beyond a marginal line of capsular zone of the main tumor on B-mode ultrasonography; 2) intensive blood signals observed within the protrusion area on Doppler ultrasonography. The large form of capsular invasion was defined if the protrusion lesion was histopathologically diagnosed to be a capsular invasion of follicular carcinoma. Results: The sensitivity of tumor protrusion was 0.071, specificity 0.994, positive predictive value 0.867, and negative predictive value 0.669 for FC diagnosis. For the large form of capsular invasion in FC the sensitivity of tumor protrusion was 0.813, specificity 0.982, positive predictive value 0.684, and negative predictive value 0.982. Conclusions: A tumor protrusion with intensive blood signals extending from the main tumor on ultrasonography strongly suggests a large form of capsular invasion of follicular carcinoma.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Patientsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Tumor protrusion with intensive blood signals on ultrasonography is a strongly suggestive finding of follicular thyroid carcinoma.

et al. 2016

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“…K. Kobayashi и соавт. (2015) 15 лет на-блюдали 10 пациентов с метастатическим раком щитовидной железы при почечно-клеточном раке [11]. В клинике Мейо за период в 55 лет выявлено 14 паци-ентов с аналогичной патологией [12].…”

Section: Introductionunclassified

Metastases of kidney cancer into the thyroid gland (сlinical observation)

Огнерубов¹,

Барсуков²,

Chang³

et al. 2017

Opuholi golovy šei

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Key words: thyroid gland, metastases, renal cell carcinomaВведение Рак почки составляет 3,9 % от общего числа онко-логической патологии [1] и 90 % всех злокачественных новообразований почки [2]. Пик заболеваемости при-ходится на 50-60 лет. У мужчин рак почки развивается чаще, чем у женщин (соответственно 4,7 и 3,3 %, или 7-е и 9-е места [1,3]).Метастатическое поражение щитовидной железы является редким случаем, хотя эта железа после надпо-чечников наиболее васкуляризирована [4][5][6][7][8]. В лите-ратуре этот факт объясняют, ссылаясь на гипотезу R. Willis (1931), согласно которой быстрый ток крови через щитовидную железу препятствует прилипанию опухолевых клеток и, кроме того, высокое содержание кислорода и йода тормозит развитие злокачественных клеток [9].Так, H. Chen и соавт. (1999) при ретроспективном исследовании выявили за 8 лет только 10 случаев ме-тастатического поражения щитовидной железы в 1 уч-реждении [10]. K. Kobayashi и соавт. (2015) 15 лет на-блюдали 10 пациентов с метастатическим раком щитовидной железы при почечно-клеточном раке [11]. В клинике Мейо за период в 55 лет выявлено 14 паци-ентов с аналогичной патологией [12].О метастатическом поражении щитовидной желе-зы сообщается в 1,4-3 % случаев среди всех операций на этом органе [13][14][15][16][17][18]. Причем среди всех злокаче-ственных новообразований чаще всего метастазируют опухоли почки (48,1 %), колоректальный рак (10,4 %), рак легких (8,3 %), рак молочной железы (7,8 %), ме-ланома (4 %) и саркома (4 %) [17,[19][20][21]. Но по ре-зультатам вскрытий частота метастазирования коле-

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Metastatic renal cell carcinoma to the thyroid with cervicothoracic venous tumor thrombosis

et al. 2023

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Introduction Metastatic renal cell carcinoma (RCC) represents 25%–42% of metastatic thyroid malignancies. Propensity for RCC to demonstrate intravascular extension to the inferior vena cava is well documented. We present an analogous phenomenon of intravascular extension to the internal jugular vein (IJV) from thyroid gland metastasis. Methods A 69‐year‐old male presented with metastatic RCC of the right thyroid lobe. Imaging demonstrated tumor thrombosis of the ipsilateral IJV, extending inferiorly to the junction of the brachiocephalic, subclavian, and internal jugular veins within the mediastinum. Results Surgical excision required control of both the IJV in the neck and mediastinal venous great vessels via sternotomy, prior to subtotal thyroidectomy and venotomy for en bloc resection. Conclusion This case report describes metastatic RCC to the thyroid gland with cervicothoracic venous tumor thrombosis successfully treated with subtotal thyroidectomy, sternotomy for venotomy and tumor thrombectomy, and preservation of IJV conduit.

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Tumor Thrombus of Thyroid Malignancies in Veins: Importance of Detection by Ultrasonography

Cited by 37 publications

References 12 publications

Tumor protrusion with intensive blood signals on ultrasonography is a strongly suggestive finding of follicular thyroid carcinoma.

Tumor protrusion with intensive blood signals on ultrasonography is a strongly suggestive finding of follicular thyroid carcinoma.

Metastases of kidney cancer into the thyroid gland (сlinical observation)

Metastatic renal cell carcinoma to the thyroid with cervicothoracic venous tumor thrombosis

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