Tumor-to-Tumor Metastasis of Renal Cell Carcinoma into Oncocytic Carcinoma of the Thyroid

Ryška, Aleš; J, Cáp

doi:10.1078/0344-0338-00361

Cited by 22 publications

(33 citation statements)

References 19 publications

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“…17 There are also reports of foci of thyroid metastases inside a pre-existing follicular adenoma 18,19 or oncocytic carcinoma of the thyroid. 20 Heffess et al 21 reported 36 patients affected by thyroid metastases from RCC with age from 53 to 80 years, a range that includes the 67 years of our patient. Other authors reported that thyroid metastases from RCC prevail in women with a F:M ratio of 6:1.…”

Section: Discussionmentioning

confidence: 92%

Thyroid metastasis of clear cell renal carcinoma: Report of a case

Rizzo

Rossi

Bonaffini

et al. 2009

Diagnostic Cytopathology

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Renal cell carcinoma can recur many years after diagnosis and nephrectomy metastasizing even in uncommon sites, including thyroid gland. Thyroid metastases are extremely rare, the most frequent site of origin are renal tumors. Metastases in thyroid gland appear as painless nodules or masses, "cold" at scintiscan. We report the case of a 67-year-old male patient affected by clear cell renal carcinoma, diagnosed by fine-needle aspiration cytology procedures, and treated with anticancer medical therapy, who noticed after some months a mass in the neck-thyroid region requiring deeper medical investigations. By this way, thyroid fine-needle aspiration cytology reported a lesion made of malignant epithelial cells compatible with metastases of renal carcinoma (clear cell). Clinical and pathological data, together with immunostaining, supported the diagnosis of metastatic clear cell renal carcinoma. The diagnosis of metastatic disease, although difficult clinically and pathologically, should be suspected in patients with a clinical history of cancer, particularly in case of renal cell carcinoma, but fine-needle aspiration cytology can provide the clue for diagnosis.

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Section: Discussionmentioning

confidence: 92%

Thyroid metastasis of clear cell renal carcinoma: Report of a case

Rizzo

Rossi

Bonaffini

et al. 2009

Diagnostic Cytopathology

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“…Very few reports of tumor-to-tumor metastasis are present in the English literature [12][13][14][15][16][17]. Several hypotheses have been proposed to explain that the proclivity of metastasis to the thyroid gland is related to its rich blood supply; however, some researchers have suggested that the abnormal thyroid gland is vulnerable to metastatic growth due to a decrease in oxygen and iodine content alteration [6].…”

Section: Discussionmentioning

confidence: 99%

“…Metastatic RCC has been described involving follicular adenoma [13][14][15]17], follicular carcinoma, oncocytic variant, Hurthle cell adenoma, and only two cases, including the present case, are RCC involving a papillary thyroid carcinoma [12,16].…”

Section: Discussionmentioning

confidence: 99%

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Tumor-to-Tumor Metastasis: Renal Cell Carcinoma Metastatic to Papillary Carcinoma of Thyroid—Report of a Case and Review of the Literature

Bohn

Casas²,

Leon

2009

Head and Neck Pathol

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Metastatic disease to thyroid gland is a rare event. Although renal cell carcinoma (RCC) has been reported to metastasize the thyroid gland, metastatic RCC to a thyroid neoplasm is very unusual. We report a case of a 68-year-old man with history of RCC who presented with a 2.5-cm thyroid nodule. Histologic examination demonstrates a renal cell carcinoma metastatic to a papillary carcinoma of the thyroid. The clinicopathologic features of metastatic disease into a thyroid gland neoplasm are shown, and a review of the literature is presented.

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“…Among these tumors, renal cell carcinoma has been the most frequent metastatic malignancy to the thyroid gland followed by those originating from the lung, gastrointestinal tract, breast, and various other tumors [3]. Interestingly, renal cell carcinoma was also the most frequent primary malignancy metastasizing to primary follicular epithelial derived thyroid neoplasm (Table 1) [4][5][6][7][8][9][10][11]. The presented case is another rare example of a solitary thyroid nodule While a comprehensive panel of markers including PAX8, TTF-1, and thyroglobulin is helpful in the distinction of thyroid follicular epithelial origin, one has to recognize the limitations associated with a single use of individual stains.…”

Section: Commentmentioning

confidence: 99%

An Unusual Solitary Thyroid Nodule with Bloody Follicles: Metastatic Renal Cell Carcinoma Within an Infiltrative Follicular Variant Papillary Carcinoma

Kefeli

Mete

2016

Endocr Pathol

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An 80-year-old woman with a recent diagnosis of invasive mammary carcinoma was found to have a left thyroid mass during routine physical examination. There was no previous exposure to ionizing radiation or known family history of thyroid cancer. Laboratory testing showed a normal TSH along with thyroid auto-antibodies. Ultrasound identified a mass measuring up to 4.0 cm. No cervical lymphadenopathy was detected. A fine-needle aspiration biopsy was performed at an outside institution. Subsequently, the patient was referred for diagnostic left hemithyroidectomy.What Is Your Diagnosis? Figures 1, 2, 3, and 4.Clinicopathological Diagnosis Metastatic renal cell carcinoma within an infiltrative follicular variant papillary thyroid carcinoma.Gross examination of the specimen confirmed a 4.0-cm tan-brown, encapsulated solid nodule with areas of hemorrhage and cystic degeneration (Fig. 1). On histological examination, the tumor displayed follicular (30 %) and solid (70 %) architecture ( Fig. 1). While the component with conventional follicular architecture displayed nuclear features of papillary thyroid carcinoma characterized by nuclear membrane irregularities and chromatin margination in enlarged nuclei, areas with solid growth had relatively smaller nuclei with nuclear membrane irregularities (Fig. 2). The solid component exhibited variable clear cell change as well as scattered follicle-like structures with a central core rich in red blood cells leading to an appearance of Bbloody follicles^ (Fig. 2). Scattered abortive papillary structures lacking true fibrovascular cores and histiocytic infiltrate were seen in the solid region (Fig. 2). No evidence of necrosis was noted. The mitotic count was less than 3 per 10 high-power fields. Cystic change was closely associated with fine-needle aspiration-related changes. There was evidence of multifocal transcapsular invasion associated with both solid and follicular architecture (Fig. 3). No evidence of extra-thyroidal extension, lymphatic invasion, or vascular invasion was found in the submitted sections. The conventional follicular component was positive for PAX8, TTF-1, and thyroglobulin, whereas the solid areas were negative for TTF-1 and thyroglobulin, and were positive for PAX8 (Fig. 4). Both regions were negative for GATA-3, parathyroid hormone, chromogranin-A, monoclonal CEA, and calcitonin. Vimentin was expressed throughout the tumor (Fig. 4). CD10 expression was prominent in the solid component (Fig. 4), but weak and patchy staining was also noted in the conventional follicular component. Positivity for PAX8, CD10, and vimentin along with negativity for TTF-1 and thyroglobulin in the solid component confirmed the diagnosis of metastatic renal cell carcinoma within an infiltrative follicular variant papillary carcinoma was rendered. Subsequently, we were informed that the patient had undergone radical nephrectomy 18 years ago for renal cell carcinoma.

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Tumor-to-Tumor Metastasis of Renal Cell Carcinoma into Oncocytic Carcinoma of the Thyroid

Cited by 22 publications

References 19 publications

Thyroid metastasis of clear cell renal carcinoma: Report of a case

Thyroid metastasis of clear cell renal carcinoma: Report of a case

Tumor-to-Tumor Metastasis: Renal Cell Carcinoma Metastatic to Papillary Carcinoma of Thyroid—Report of a Case and Review of the Literature

An Unusual Solitary Thyroid Nodule with Bloody Follicles: Metastatic Renal Cell Carcinoma Within an Infiltrative Follicular Variant Papillary Carcinoma

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