Tumor treating fields: a new treatment for glioblastoma

Slavkov, Dimitar; Hadzhiyanev, Asen; Slavkova, Svetoslava

doi:10.1080/13102818.2022.2155567

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…A number of recent studies reported NMs-assisted GBS therapy for instance ferroptosis, gene therapy (GT) [ 266 , 273 ], radiotherapy [ 274 ], photothermal therapy (PTT) [ 275 ], magnetothermal therapy [ 276 , 277 ], and immunotherapy [ 278 ]. Ferroptosis is an iron-mediated apoptosis distinguished from necrosis, autophagy [ 279 ], apoptosis, and pyroptosis [ 280 ].…”

Section: Neurological Diseases Associated With Signaling Pathways Of ...mentioning

confidence: 99%

Deeper insight into ferroptosis: association with Alzheimer’s, Parkinson’s disease, and brain tumors and their possible treatment by nanomaterials induced ferroptosis

Yadav,

Choudhary,

Gacem

et al. 2023

Redox Report

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Ferroptosis is an emerging and novel type of iron-dependent programmed cell death which is mainly caused by the excessive deposition of free intracellular iron in the brain cells. This deposited free iron exerts a ferroptosis pathway, resulting in lipid peroxidation (LiPr). There are mainly three ferroptosis pathways viz. iron metabolism-mediated cysteine/glutamate, and LiPr-mediated. Iron is required by the brain as a redox metal for several physiological activities. Due to the iron homeostasis balance disruption, the brain gets adversely affected which further causes neurodegenerative diseases (NDDs) like Parkinson's and Alzheimer's disease, strokes, and brain tumors like glioblastoma (GBS), and glioma. Nanotechnology has played an important role in the prevention and treatment of these NDDs. A synergistic effect of nanomaterials and ferroptosis could prove to be an effective and efficient approach in the field of nanomedicine. In the current review, the authors have highlighted all the latest research in the field of ferroptosis, specifically emphasizing on the role of major molecular key players and various mechanisms involved in the ferroptosis pathway. Moreover, here the authors have also addressed the correlation of ferroptosis with the pathophysiology of NDDs and theragnostic effect of ferroptosis and nanomaterials for the prevention and treatment of NDDs.

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Section: Neurological Diseases Associated With Signaling Pathways Of ...mentioning

confidence: 99%

Deeper insight into ferroptosis: association with Alzheimer’s, Parkinson’s disease, and brain tumors and their possible treatment by nanomaterials induced ferroptosis

Yadav,

Choudhary,

Gacem

et al. 2023

Redox Report

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Implantable Ultrasound‐Powered MXene/PVA Hydrogel‐Based Generator for Treatment of Glioblastoma

Hu,

Qiu,

Yang

et al. 2024

Advanced Science

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Glioblastoma (GBM) is a lethal disease with a poor prognosis due to its strong infiltration, which makes it difficult to remove completely. In this study, an implantable, modulus‐tunable, and ultrasound‐powered MXene/PVA hydrogel‐based tumor treatment device (UP‐MPH‐TTD), which generates specific electromagnetic alternating fields that disrupt the mitosis of cancer cells without adversely affecting normal neurons is developed. The MXene/PVA hydrogel is used to form a tumor treatment field due to its high biocompatibility, excellent flexibility, and high conductivity, which improves ultrasonic electrical conversion efficiency and significantly reduces the size of the equipment. The implantable UP‐MPH‐TTD is wirelessly ultrasound‐powered, small‐sized, lightweight, and simply structured, significantly boosting therapeutic efficiency and reducing restrictions on patient movement. In vitro and in vivo experiments confirmed the device's therapeutic effect, demonstrating a ≈92% inhibition rate in the growth of clinical tumor cells and a 73% reduction in tumor area in tumor‐bearing mice. The promising results indicate the broad application potential of the device in the treatment and prognostic improvement of GBM.

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Directionally non-rotating electric field therapy delivered through implanted electrodes as a glioblastoma treatment platform: A proof-of-principle study

Ma,

Singh,

et al. 2024

Neuro-Oncology Advances

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Background While directionally rotating Tumor Treating Fields (TTF) therapy has garnered considerable clinical interest in recent years, there has been comparatively less focus on directionally non-rotating electric field therapy (dnEFT). Methods We explored dnEFT generated through customized electrodes as a glioblastoma therapy in in vitro and in vivo pre-clinical models. The effects of dnEFT on tumor apoptosis and microglia/macrophages in the tumor microenvironment were tested using flow-cytometric and qPCR assays. Results In vitro, dnEFT generated using a clinical grade spinal cord stimulator showed anti-neoplastic activity against independent glioblastoma cell lines. In support of the results obtained using the clinical grade electrode, dnEFT delivered through a customized, two-electrode array induced glioblastoma apoptosis. To characterize this effect in vivo, a custom-designed four-electrode array was fabricated such that tumor cells can be implanted into murine cerebrum through a center channel equidistant from the electrodes. After implantation with this array and luciferase expressing murine GL261 glioblastoma cells, mice were randomized to dnEFT or placebo. Relative to placebo treated mice, dnEFT reduced tumor growth (measured by bioluminescence) and prolonged survival (median survival gain of 6.5 days). Analysis of brain sections following dnEFT showed a notable increase in the accumulation of peri-tumoral macrophage/microglia with increased expression of M1 genes (IFNγ, TNFα, IL-6) and decreased expression of M2 genes (CD206, Arg, IL-10) relative to placebo treated tumors. Conclusions Our results suggest therapeutic potential in glioblastoma for dnEFT delivered through implanted electrodes, supporting the development of a proof-of-principle clinical trial using commercially available deep brain stimulator electrodes.

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Tumor treating fields: a new treatment for glioblastoma

Cited by 3 publications

References 24 publications

Deeper insight into ferroptosis: association with Alzheimer’s, Parkinson’s disease, and brain tumors and their possible treatment by nanomaterials induced ferroptosis

Deeper insight into ferroptosis: association with Alzheimer’s, Parkinson’s disease, and brain tumors and their possible treatment by nanomaterials induced ferroptosis

Implantable Ultrasound‐Powered MXene/PVA Hydrogel‐Based Generator for Treatment of Glioblastoma

Directionally non-rotating electric field therapy delivered through implanted electrodes as a glioblastoma treatment platform: A proof-of-principle study

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