Tumor Treating Fields for Ovarian Carcinoma: A Modeling Study

Abstract

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Hydrogel Conductivity Impacts Skin Dose from Tumor Treating Fields

“…PET data was used to aid the delineation of the PET-positive gross tumor volume (GTV) in the lung models, where a uniform 3 mm expansion around the GTV was performed to create the clinical target volumes (CTV). Method of target delineation for the pelvic models were similarly described in our prior publication (13). A 3-dimensional nite element mesh was then generated for each model in ScanIP (Synopsys, Mountain View, CA) and then imported into COMSOL Multiphysics 5.5 (COMSOL, Burlington, MA).…”

“…Head models were not modeled with electric conductivity of the hydrogel set beyond 10 S/m due to lower potential electric eld saturation, while the thorax and pelvis models employed hydrogel electric conductivity values beyond 10 S/m and up to 1000 S/m due to the assumption that a larger girth of the body would require a higher electric eld penetration. Appropriate material properties and boundary conditions as described in prior studies were then speci ed, and magnetic elds were assumed to be negligible at the frequency range for the operation of TTFields (12,13). The AC/DC module from COMSOL Multiphysics was used to solve for the electric eld distribution in each model.…”

Nanotechnology and Cancer Bioelectricity: Bridging the Gap Between Biology and Translational Medicine

“…[21,189] Ongoing clinical trials are showing promising results also in the treatment of non-small cell lung cancer, pancreatic cancer, and ovarian cancer. [17,23] TTFs can be delivered using a portable medical device called Optune, consisting of a set of insulated electrodes placed on the patient's scalp. [22] Combination therapies have also attracted interest as a method to enhance TTFs efficacy, for example by combination with immunotherapy.…”

“…[17][18][19][20][21] These methods aim to overcome the side effects associated to traditional cancer treatments, such as chemotherapy and radiation therapy. [22,23] Complementary approaches based on bioelectricity have been also considered to enhance the effectiveness of existing therapeutic strategies. For instance, a recent field of research, known as electroceuticals, aims to use electrical signals to manipulate cellular behavior and induce therapeutic effects.…”

Tumor treating fields (TTFields) for spinal metastasis—The case for bone removal and spinal implants as waveguides to enhance field strength at the target

“… 3 Its mechanism of action relates to the disruption of the mitotic spindle in rapidly dividing cancer cells through the dielectrophoretic effect. 4 Simulations of the distribution of TTFields strength in the intracranial, 5 thoracic, 6 abdominal, 7 and pelvic 8 compartments using finite element models that assign tissue-specific electric properties (ie, conductivity, permittivity) to the different tissue layers overlying the tumor. TTFields strength, and therefore efficacy, is inversely proportional to the tissue conductivity in the intervening tissues.…”