Tumoral calcinosis of the foot: An unusual differential diagnosis of calcaneal mass

Eraghi, Amir Sobhani; Athari, Babak; Rahimabad, Parnian Kheirkhah

doi:10.1016/j.ijscr.2015.04.006

Cited by 4 publications

(3 citation statements)

References 7 publications

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“…A baseline biochemical workup like serum calcium, phosphorus, parathormone, 1, 25 dihydroxy vitamin D levels and renal function tests is mandatory to exclude differentials. History and clinical examination when in doubt of connective tissue disorder antinuclear, antismith, anticentrome and antiscleroderma antibodies are to be done [4,10] .…”

Section: Discussionmentioning

confidence: 99%

Long follow-up of Multiple Recurrent Calcific Masses–A rare case report of Hyperphosphatemic Familial Tumoral Calcinosis

Ahmed¹,

Saeed

Farooq

et al. 2022

JUMDC

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Hyperphosphatemic familial tumoral calcinosis (HFTC) is an autosomal recessive benign condition of dysregulated phosphate metabolism (biallelic mutation in GLANT3, KLOTHO or FGF23) due to deficiency or resistance of intact fibroblast growth factor 23 resulting in deposition of large amount of ectopic calcium salts in periarticular soft tissues. We present a 21-year male with multiple recurrent masses around both hips, feet, left knee, and left elbow. His serum inorganic phosphate levels and ratio of renal tubular reabsorption rate of phosphate to corrected glomerular filtration rate were markedly elevated. Medical treatment to lower serum phosphate levels by placing him on tablet sevelamer hydrochloride and acetazolamide and surgical excision of the periarticular masses lead to disease remission. At 4 years follow up he has no recurrence and his functional scores (SF 36 and Harris Hip Score) have tremendously improved. Tumoral calcinosis, though rare must be kept in mind as a differential in abnormal calcific masses and with good radiological and laboratory support can be diagnosed early.

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Section: Discussionmentioning

confidence: 99%

Long follow-up of Multiple Recurrent Calcific Masses–A rare case report of Hyperphosphatemic Familial Tumoral Calcinosis

Ahmed¹,

Saeed

Farooq

et al. 2022

JUMDC

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“…Associations with end-stage renal disease, scleroderma, vitamin D toxicity, and hyperparathyroidism have also been established. 32 TC can be found in any age group but is mainly prevalent in the first and second decades of life, and it has a strong predominance with the African American population. 32 Patients present with a firm, nontender mobile mass in the periarticular soft tissue with a focal functional deficit of the joint if it is large.…”

Section: Metabolic Mimics Tumoral Calcinosismentioning

confidence: 99%

“…32 TC can be found in any age group but is mainly prevalent in the first and second decades of life, and it has a strong predominance with the African American population. 32 Patients present with a firm, nontender mobile mass in the periarticular soft tissue with a focal functional deficit of the joint if it is large. Superficial skin ulceration with drainage of a chalky milk-type consistency is also a common finding.…”

Section: Metabolic Mimics Tumoral Calcinosismentioning

confidence: 99%

Non-neoplastic Soft Tissue Tumors and Tumor-like Lesions

Shah

Paramesparan

Robinson

et al. 2020

Semin Musculoskelet Radiol

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Clinicians are commonly faced with patients presenting with a solitary palpable soft tissue mass. Most soft tissue lesions are benign, and not every mass is due to a neoplastic process. Many pathologies can mimic a malignant tumor. Despite appropriate clinicoradiologic assessment, these lesions can be mistaken for a soft tissue sarcoma and can lead to multiple investigations or an intervention, inconveniencing patients and leading to an increased health care cost. With the relevant clinical history, clinical examination, and specific imaging characteristics, the diagnosis can be narrowed. We present a pictorial review of soft tissue sarcoma mimics with guidance on appropriate differential diagnoses.

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