Tumoren der Ratte nach i.p.-Injektion faserf�rmiger St�ube

Pott, F.; Friedrichs, K. H.

doi:10.1007/bf00593370

Cited by 115 publications

(30 citation statements)

References 2 publications

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“…The experiments mentioned in the introduction to this paper, as well as subsequent ones, have shown that man-made mineral fibers administered intratracheally may be capable of eliciting pulmonary fibrosis in guinea pigs (13) and, to a less degree, in rats (2), and lung cancer and pleural mesotheliomas in hamsters (20). By pleural administration they have been clearly shown to induce mesotheliomas in rats (19,30,31), the same effect being obtained by intraperitoneal administration in rats (21). By inhalation, on the contrary, less than "minimal" pulmonary fibrosis was found in rats, and no detectable carcinogenic effect in rats and hamsters (in experiments involving a total of about 600 animals) (14,29,35).…”

Section: An Overview Of the Epidemiologic Evidencementioning

confidence: 61%

“…The second cause of attention is the results of animal experiments clearly showing that man-made mineral fibers are capable of inducing cancer, namely, mesothelioma in the pleura and peritoneum, when directly deposited in these cavities and fibrosis when intratracheally administered (13,19,21,30). These biological test systems may be regarded as rather special in respect to the route of administration, but no one has yet, to my knowledge, seriously questioned the validity by itself of these experiments.…”

Section: Relevance Of the Issuementioning

confidence: 99%

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Man-made mineral fibers and health. Answered and unanswered questions.

Saracci¹

1985

Scand J Work Environ Health

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SARACCI, R. Man-mademineral fibersand health: Answered and unansweredquestions. Scand J Work Environ Health II (1985) 215-222. An overall assessment of the epidemiologic evidence from 23 published studies on workers' health in the industry producing man made mineral fibers (MMMF) (21 studies) and in the user industry (2 studies)is presented. Three major studies recently published, one crosssectional and two of the historical cohort type, conducted in the producer industry, have been singled out for closer examination and discussion. The combinedevidence from the epidemiologic studies indicates that causal associationsbetweenMMMFoccupationalexposure,as it occurred in past decades, and lung cancer and chronic respiratory diseases cannot be excluded, neither does it offer clear support for such associations. Experimental data indicate clearlythat a fibrogenic effect can be obtained by the intratracheal administration of MMMF and a carcinogenic effect by the intratracheal, intrapleural, and intraperitoneal administration of MMMF, whileno appreciablyfibrogenic nor carcinogenic effects have been detected in inhalation experiments. While it can be stated that no long-term pathological effects have been observedin MMMFworkersin the first 20 yearsor so after first employment, the key scientific issue of whether MMMF are fibrogenic and/or carcinogenic in man when inhaled remains still open.

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Section: An Overview Of the Epidemiologic Evidencementioning

confidence: 61%

Section: Relevance Of the Issuementioning

confidence: 99%

Man-made mineral fibers and health. Answered and unanswered questions.

Saracci¹

1985

Scand J Work Environ Health

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“…Early studies showed that gypsum fibers (2) and later, HCl-leached chrysotile fibers (3) dissolved in the intraperitoneal cavity a few days after injection and that the leached chrysotile was as acutely toxic as amorphous silicic acid. Those studies led to the conclusion that the chemical composition of a fiber, although not responsible for fiber carcinogenesis, did modify the carcinogenic potency from fiber type to fiber type, with variations that ranged between noncarcinogenicity and the carcinogenicity of crocidolite asbestos.…”

Section: Introduction -Early Resultsmentioning

confidence: 99%

Significance of Durability of Mineral Fibers for Their Toxicity and Carcinogenic Potency in the Abdominal Cavity of Rats in Comparison with the Low Sensitivity of Inhalation Studies

Pott¹,

Roller²,

Kamino³

et al. 1994

Environmental Health Perspectives

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At the same time that carcinogenicity of very thin glass fibers after intrapleural and intraperitoneal (ip) administration was demonstrated (1,2) researchers found that gypsum fibers and HCI-leached chrysotile fibers were easily soluble in the peritoneal cavity. This led to the conclusion that the chemical composition of fibers was not responsible for the carcinogenesis but that the degree of carcinogenic potency of a fiber depended on the extent to which it retained its fibrous structure. A thin glass fiber with a low biodurability did not induce tumors after ip injection of a high dose, although the ip test had been criticized for being "overly sensitive." The ip model has been the most successful for determining carcinogenicity of inorganic fibers and establishing dose-response relationships; but to determine the possibilities and limitations of this test model, very high doses of nonfibrous silicon carbide and of a slightly durable glass fiber type were injected ip in Wistar rats. No obviously acute or chronic toxic effect was observed in 90 weeks, but there was a 40% incidence of serosal tumors in the group treated with glass fibers. A pilot study on the persistence of slag fibers in the omentum of rats after ip injection showed a half-time of about 1 year. It was calculated that an ip injection of 109 fibers would lead to a concentration of fiber numbers in the ash of the omentum in the same range as the concentration in the lung after 2 years of inhalation exposure. The long-term inhalation study with fibers in rats has been called the "gold standard" for risk characterization. However, the tumor risk from inhalation of asbestos fibers in man has been estimated to be about 200 times higher per fiber than the risk in rats. The concentration of crocidolite fibers in the lung of rats in an inhalation study that was negative was more than 1 000-fold higher than the median concentration of amphibole fibers in the lungs of asbestos workers with mesotheliomas. This great difference clearly indicates that the sensitivity of the inhalation model is too low for the identification of the carcinogenic potential of mineral fibers. -Environ Health Perspect 102(Suppl. 5): 145-150 (19941

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“…Limited data on the biological activities of feldspar (e.g., Marks and Nagelschmidt, 1959;Pott and Friedrichs, 1972) suggest that this mineral is mildly active, at most. No published studies suggest that feldspar is carcinogenic in either humans or animals.…”

Section: Feldsparmentioning

confidence: 99%

Distribution of potentially hazardous phases in the subsurface at Yucca Mountain, Nevada

Guthrie¹,

Bish²,

Raymond³

1995

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Los Alamos ABSTRACTDrilling, trenching, excavation of the Exploratory Studies Facility, and other surface-and underground-distributing activities have the potential to release minerals into the environment from tuffs at Yucca Mountain, Nevada. Some of these minerals may be potential respiratory health hazards. Therefore, an understanding of the distribution of the minerals that may potentially be liberated during site-characterization and operation of the potential repository is crucial to ensuring worker and public safety. Analysis of previously reported mineralogy of Yucca Mountain tuffs using data and criteria from the International Agency for Research on Cancer (IARC) suggests that the following minerals are of potential concern: quartz, cristobalite, tridymite, opal-CT, erionite, mordenite, and palygorskite. We have re-evaluated the three-dimensional mineral distribution at Yucca Mountain above the static water level both in bulk-rock samples and in fractures, using quantitative X-ray powder diffraction analysis. Erionite, mordenite, and palygorskite occur primarily in fractures; the crystalline-silica minerals, quartz, cristobalite, and tridymite are major bulk-rock phases. Erionite occurs in the altered zone just above the lower Topopah Spring Member vitrophyre, and an occurrence below the vitrophyre but above the Calico Hills has recently been identified. In this latter occurrence, erionite is present in the matrix at levels up to 35 wt%. Mordenite and palygorskite occur throughout the vadose zone nearly to the surface. Opal-CT is limited to zeolitic horizons.

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Tumoren der Ratte nach i.p.-Injektion faserf�rmiger St�ube

Cited by 115 publications

References 2 publications

Man-made mineral fibers and health. Answered and unanswered questions.

Man-made mineral fibers and health. Answered and unanswered questions.

Significance of Durability of Mineral Fibers for Their Toxicity and Carcinogenic Potency in the Abdominal Cavity of Rats in Comparison with the Low Sensitivity of Inhalation Studies

Distribution of potentially hazardous phases in the subsurface at Yucca Mountain, Nevada

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