Tumores neuroendócrinos do cólon e reto: experiência do Instituto Nacional do Câncer no Brasil

Cesar, Daniel; Zanatto, Renato Morato; Silva, Marcus Vinícius Motta Valadão da; Golçalves, Rinaldo; Mello, Eduardo Linhares Riello de; Jesus, José Paulo de

doi:10.1590/s0102-67202013000100008

Cited by 7 publications

(10 citation statements)

References 14 publications

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“…Most rectal carcinoid tumors are small and movable subepithelial lesions located between 4 and 20 cm above the dentate line and are mainly discovered incidentally on routine lower endoscopy (7, 8, 9, 10). Such a small tumor rarely metastasizes and endoscopic resection is curative.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Preceding Biopsy on Complete Endoscopic Resection in Rectal Carcinoid Tumor

et al. 2014

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Biopsy of rectal carcinoid tumor is commonly taken before endoscopic resection. However the preceding biopsy can inhibit complete resection by causing blurred tumor border and fibrosis of the tissue. The objective of the study was to investigate the effect of preceding biopsy on complete endoscopic resection in rectal carcinoid tumor. It was also determined if rectal carcinoid tumors can be macroscopically distinguished by endoscopy. We reviewed retrospectively the records of patients with rectal carcinoid tumor who had undergone an endoscopic treatment at our hospital, during a 7-yr period. The resection margin was clear in 57 of 98 cases. The preceding biopsy was taken in 57 cases and the biopsy was significantly associated with the risk of incomplete tumor resection (OR, 3.696; 95% CI, 1.528-8.938, P = 0.004). In 95.9% of the cases, it was possible to suspect a carcinoid tumor by macroscopic appearance during initial endoscopy. The preceding biopsy may disturb complete resection of rectal carcinoid tumor. In most cases, the carcinoid tumor could be suspected by macroscopic appearance. Therefore the preceding biopsy is not essential, and it may be avoided for the complete resection.Graphical Abstract

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Section: Introductionmentioning

confidence: 99%

The Effect of Preceding Biopsy on Complete Endoscopic Resection in Rectal Carcinoid Tumor

et al. 2014

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“…Colorectal NENs are mostly non-functional, and while often presenting similarly to adenocarcinomas, are both pathologically and in terms of their behavior quite distinct (Portale et al, 2012;Cesar et al, 2013). It has long been widely recognized that there are distinct differences in terms of the epidemiology, clinical manifestations and prognosis between rightand left-sided colorectal adenocarcinomas, with the National Comprehensive Cancer Network (NCCN) guidelines (Benson et al, 2017) confirming the significance of the primary tumor location in the treatment of metastatic colorectal cancer (mCRC).…”

mentioning

confidence: 99%

Difference in survival between right- versus left-sided colorectal neuroendocrine neoplasms

Zou

Grossman

2019

J. Zhejiang Univ. Sci. B

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“…Within the gastrointestinal tract, the small intestine, cecal appendix, and rectum are the principal sites of affliction. Neuroendocrine tumors of the small intestine, although less common than those in the lung and rectum, hold the third most frequent position in this spectrum [14,27,28]. Despite their rarity, comprising around 3% of all primary duodenal tumors, these small intestine tumors are noteworthy for being the most prevalent site for distant metastasis formation [14].…”

Section: Despitementioning

confidence: 99%

“…The distal ileum is the most commonly affected site, often exhibiting a multicentric pattern likely originating from intraepithelial endocrine cells producing serotonin [2,3,9,18]. Symptomatology encompasses intermittent abdominal discomfort, subocclusive symptoms, and potential nonsecretory diarrhea [14,26,27,28,29].…”

Section: Despitementioning

confidence: 99%

Neuroendocrine Tumor of the Small Intestine in a Patient from the Northern Fluminense Region of the Province of Rio de Janeiro, Brazil

Filho,

Machado,

Campos

et al. 2023

JAMMR

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Neuroendocrine tumors are a rare class of malignant epithelial neoplasms characterized by prominent neuroendocrine differentiation. Cells within these tumor types display a unique blend of neuronal and endocrine capacities, enabling them to secrete both hormones and neurotransmitters. The distribution of these tumors is most frequently observed in the stomach, colon, rectum, appendix, pancreas, and bronchopulmonary complex. The primary objective of this article is to present a case report of a patient diagnosed with an ileal neuroendocrine tumor that initially manifested as intestinal subocclusion. A 54-year-old Afro-Brazilian male presented clinical signs of intestinal subocclusion. Diagnostic imaging revealed bilateral pleural effusion, marked small bowel dilation, and a narrowed ileal loop, suggestive of mechanical obstruction. Surgical intervention included segmental enterectomy and ileal anastomosis, with pathological analysis indicating a neuroendocrine tumor with potential confirmation through immunohistochemistry. The patient is currently under oncology department care for ongoing monitoring. The present investigation delineates a quintessential case, emblematic of the prevailing diagnostic and therapeutic norms prevalent in the northern reaches of Rio de Janeiro. It meticulously elucidates the diverse determinants that underpin the diagnostic journey and therapeutic stratagem instrumental in the successful eradication of an ileal neuroendocrine tumor. The clinical strategies adopted in this endeavor concur with established European and North American guidelines governing the resection of neuroendocrine tumors of the small intestine.

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Tumores neuroendócrinos do cólon e reto: experiência do Instituto Nacional do Câncer no Brasil

Cited by 7 publications

References 14 publications

The Effect of Preceding Biopsy on Complete Endoscopic Resection in Rectal Carcinoid Tumor

The Effect of Preceding Biopsy on Complete Endoscopic Resection in Rectal Carcinoid Tumor

Difference in survival between right- versus left-sided colorectal neuroendocrine neoplasms

Neuroendocrine Tumor of the Small Intestine in a Patient from the Northern Fluminense Region of the Province of Rio de Janeiro, Brazil

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