Tumorigenesis by N-n-propyl-N-formylhydrazine in mice

Abstract

Summary.-Continuous administration of 0.040/0 N-n-propyl-N-formylhydrazine (PFH) for life in drinking water to 6-week-old randomly bred Swiss mice induced tumours of the lungs, preputial glands, liver and gall bladder. The tumour incidences in these 4 tissues were 91, 22, 8 and 6%, whereas in the untreated controls they were 25,0,0-5 and 0.50", respectively. The higher dose of 0.080/( PFH, given under identical conditions, induced only tumours of the lungs, liver and gall bladder in lower incidences, since the compound was too toxic for the mice. Histopathologically, the tumours were classified as adenomas and adenocarcinomas of the lungs, squamouscell papillomas, and carcinomas and fibrosarcoma of preputial glands, benign hepatomas and liver-cell carcinoma, as well as adenomas and adenocarcinoma of the gall bladder.

Analysis of agaritine in mushrooms and in agaritine-administered mice using liquid chromatography–tandem mass spectrometry

“…There are, however, also reports showing that agaritine does have a direct mutagenic effect. The mutagenicity of agaritine can be attributed directy to 4-(hydroxymethyl)phenylhydrazine (HMPH) and/or the 4-(hydroxymethyl)benzenediazonium ion (HMBD), both of which are formed by the eenzymatic degradation of agaritine that results in the loss of the ␥-glutamyl group [10][11][12][13]. HMPH and HMBD are highly unstable and are carcinogenic [10,12,14].…”

Phenolic Compounds in Food and Cancer Prevention

“…Some studies, however, have indicated that high levels of α-tocopherol can enhance tumorigenenesis in the intestines of rodents treated with 1,2-dimethylhydrazine (145,146). In addition, many studies have found no effect of α-tocopherol on tumorigenesis (147,148).…”

Predisposed to toxins: Association of gallbladder cancer with N-acetyl transferase SNPs

“…5 Significantly, mice exposed to N-hydroxy-2-acetamidofluorene, 6 an inhibitor of N-acetyl transferases, develop GBC. Further, murine exposure to the hydrazines N-n-propyl-N-formylhydrazine, 7 or N-methyl-N-formylhydrazine 8 causes GBC supporting a role for environmental hydrazines in gallbladder carcinogenesis.…”