Tumorigenesis of a v-Ha-ras-expressing pre-B cell line selects for c-myc activation

Chen, Shu Chih; Redenius, Diane; Schwartz, Richard C.

doi:10.1016/0006-291x(91)91041-a

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1999

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“…The ras gene, in addition to its other transforming activities, can also activate c-myc [18,19]. It is therefore possible that the induction of CD80 by k-ras is a secondary effect due to alteration of myc function in the k-rastransformed cells.…”

Section: Discussionmentioning

confidence: 99%

A Novel Stimulus, Oncogene, Induces Expression of CD80 (B7-1) Gene

et al. 1999

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CD80, a cell surface molecule found on antigen-presenting cells which particpates in costimulatory signaling, is frequently detected on transformed and tumor cells. We examined the effect of transformation by v-myc, k-ras, and SV40 T antigen oncogenes on the expression of a CD80 promoter/luciferase gene as well as the endogenous CD80 promoter gene in murine fibroblast cell lines. All three transformed cell lines were tumorigenic in nude mice, however expression of the CD80/luciferase transgene or endogenous CD80 was detected only in the v-myc and k-ras transformed cell lines. In both cell lines, CD80 expression was first detected more than 30 passages after transformation. Therefore, induction of CD80 expression was a late event following transformation and was not essential for the establishment of the transformed phenotype.

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Section: Discussionmentioning

confidence: 99%